The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy

Research Communications in Molecular Pathology and Pharmacology

Volumn 117-118, Issue , 2005, Pages 137-151

  Walubo, Andrew ^a   Coetsee, Christa ^a   Arti, Dhar ^a   Du Plessis, J B ^a  

^a UNIVERSITY OF THE FREE STATE   (South Africa)

Author keywords

CYP2E1; Isoniazid; Lymphocytes and tuberculosis

Indexed keywords

6 HYDROXYCHLORZOXAZONE; CHLORZOXAZONE; CYTOCHROME P450 2E1; ISONIAZID;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE CLEARANCE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; KIDNEY FUNCTION; LIVER TOXICITY; MALE; MEASUREMENT; MICROSOME; PERIPHERAL LYMPHOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK FACTOR; TUBERCULOSIS;

ADULT; ANTITUBERCULAR AGENTS; CHLORZOXAZONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; ISONIAZID; LYMPHOCYTES; MALE; MICROSOMES; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; RISK FACTORS; TUBERCULOSIS, PULMONARY;

EID: 40549125630     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Brouet G., Collaborative study of short term anti-bacillary treatment in 14 French centres. Bull. Int. Un. TB. 1974; 49: 369-374.
2. Ekstrom, G. and Ingleman-Sundberg, M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem. Pharmacol. 1989; 38, 1313-1319.
3. Frye, R.F. and Stiff, D.D. Determination of Chlorzoxazone and 6-hydroxychlorxozaxone in human plasma and urine by high performance liquid chromatography. Journal of Chromatography B. 1996; 686: 291-296.
4. Girling DJ. The hepatic toxicity of anti-tuberculous regimens containing isoniazid, rifampicin, and pyrazinamide. Tubercle. 1978; 59: 13-32.
5. Gregus Z and Klaassen CD: Mechanisms of toxicity, Chapter 3. In: Casaret's & Doull toxicology; 5th edtn. Ed. CD Klaassen. McgraHill, 1996, p 35.
6. Grohagen-Riska C, Hellstrom P and Froseth B. predisposing factors in hepatitis induced by isoniazid rifampicin treatment of tuberculosis. Am. Rev. Respir. Dis., 1978; 118: 461-466.
7. Guegerich, F.P., Kim, D.H. and Iwasaki, M. Role of human cytochrome P-450IIE1 in the oxidation of many low molecular wieght cancer suspects. Chem. Res. Toxicol. 1991; 4: 168-179.
8. Guengerich FP and Shimada T. Oxidation of toxic and carcinogenic chamecals by human cytochrome P450 enzymes. Chem. Res. Toxicol. 1991; 4: 391-407.
9. Guengerich FP. Characterisation of human microsomal cytochrome P-450 enzymes. Annu. Rev. Pharmacol. Toxicol. 1989; 29: 241-264.
10. Kopanoff DE, Snider DE and Caras GJ. Isoniazid related hepatitis. A United States Public Health Service cooperative surveillance study. Amer. Rev. Respir. Dis. 1978; 117: 991-1001.
11. Mitchell JR, Zimmerman HJ, Ishak KG, Thorgeirsson UP, Timbrell JA, Snodgrass WR and Sidney DN. Isoniazid liver injury: clinical spectrum, pathology and probable pathogenesis. Ann. Intern. Med., 1976; 84: 181-192.
12. Montoliu, C., Sancho-Tello, M., Azorin, I., Burgal, M., Valles, S., Renau-Piqueras, J. and Guerri, C. Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes. J. Neurochem. 1995; 65, 2561-2570.
13. th edtn, Ed. CD Klaassen. McgraHill, 1996, p. 201.
14. Riska N. Hepatitis cases in isoniazid treated group and in a control group. Bull. Int. Un. Agnst.TB, 1976; 51: 203-208.
15. Runge-Morris M, Feng Y, Zanger RC and Novak RF. Effects of hydrazine, phenelzine and hydralazine treatment on rat hepatic and renal drug-metabolizing enzyme expression. Drug Metab. Disp. 1996; 24: 734-737.
16. Sarma RG, Chandra I, Kailasam S, Narayama ASL and Venkatesan P. Rifampicin induced release of hydrazine from isoniazid. Am. Rev. Respir. Dis., 1986; 133: 1072-1075.
17. Walubo A, Smith P, and Folb PI; Oxidative stress during antiutberculous elderly patients. Biomedical and Environmental Sciences. 1995; 8: 106-113.
18. Wrighton SA, Thomas PE, Ryan DE et al. Characterization of ethanol inducible human liver N-nitrosodimethylamine demthylase. Biochemistry 1986; 25: 6731-6735.
19. Zand R, Nelson SD, Slattery JT, Thummel KE, Kalhorn TF, Adams SP and Wright JM. Inhibition and induction of cytochrome P4502E1-catalysed oxidation by isoniazid in humans. Clin. Pharmacol. Ther. 1993; 54: 142-149.