Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Wang, Yong ^a   Hu, Hai Hong ^b   Pang, Hao ^a   Zhou, Xiao Yang ^a   Yu, Lu Shan ^b   Wang, Lu Lu ^a   Liu, Cang'e ^a   Guo, Ke Nan ^a   Zhao, Cong ^c   Liu, Qin ^a   Zeng, Ben Hua ^a   Tang, Huan ^a   Shang, Hai Tao ^a   Zeng, Su ^b   Wei, Hong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c SOUTHWEST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; CYTOCHROME P450 3A16; CYTOCHROME P450 3A41; CYTOCHROME P450 3A44; LENTIVIRUS VECTOR; MICRORNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; CYP3A PROTEIN, MOUSE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; GENDER; GENE EXPRESSION; GENE TARGETING; MOUSE; NONHUMAN; PROGENY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION REGULATION; TRANSGENICS; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; GENE DOSAGE; GENE VECTOR; GENETICS; HUMAN; INHERITANCE; LENTIVIRINAE; MALE; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA; MURINAE; MUS; MUS MUSCULUS;

ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE DOSAGE; GENETIC VECTORS; HUMANS; INHERITANCE PATTERNS; LENTIVIRUS; MALE; MICE; MICE, TRANSGENIC; MICRORNAS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84856179132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030560     Document Type: Article

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