Spinal excitation and inhibition decrease as humans age

Canadian Journal of Physiology and Pharmacology

Volumn 82, Issue 4, 2004, Pages 238-248

  Kido, Aiko ^a   Tanaka, Naofumi ^b   Stein, Richard B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Age; H reflex; Reciprocal inhibition

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; HOFFMANN REFLEX; HUMAN; NERVE FIBER; NORMAL HUMAN; PERONEUS NERVE; PRIORITY JOURNAL; SOLEUS MUSCLE; SPINAL REFLEX; TIBIAL NERVE; TIBIALIS ANTERIOR MUSCLE; VOLUNTARY MOVEMENT; WALKING;

ADULT; AGED; AGING; CANADA; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; H-REFLEX; HUMANS; JAPAN; MIDDLE AGED; MOTOR NEURONS; MOVEMENT; MUSCLE, SKELETAL; MUSCULOSKELETAL EQUILIBRIUM; TIBIAL NERVE; WALKING;

EID: 3042798254     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y04-017     Document Type: Article

References (45)

1. Angulo-Kinzler, R.M., Mynark, R.G., and Koceja, D.M. 1998. Soleus H-reflex gain in elderly and young adults: modulation due to body position. J. Gerontol. 53: M120-M125.
2. Boxer, P.A., Morales, F.R., and Chase, M.H. 1988. Alterations of group Ia-motoneuron monosynaptic EPSPs in aged cats. Exp. Neurol. 100: 583-595.
3. Brooke, J.D., Singh, R., Wilson, M.K., Yoon, P., and McIlroy, W.E. 1989. Aging of human segmental oligosynaptic reflexes for control of leg movement. Neurobiol. Aging, 10: 721-725.
4. Brooke, J.D., Cheng, J., Misiaszek, J.E., and Lafferty, K. 1995. Amplitude modulation of the soleus H reflex in the human during active and passive stepping movements. J. Neurophysiol. 73: 102-111.
5. Brooke, J.D., Cheng, J., Collins, D.F., McIlroy, W.E., Misiaszek, J.E., and Staines, W.R. 1997. Sensori-sensory afferent conditioning with leg movement: gain control in spinal reflex and ascending paths. Prog. Neurobiol. 51: 393-421.
6. Capaday, C. 1997. Neurophysiological methods for studies of the motor system in freely moving human subjects. J. Neurosci. Methods, 74: 201-218.
7. Capaday, C., and Stein, R.B. 1986. Amplitude modulation of the soleus H-reflex in the human during walking and standing. J. Neurosci. 6: 1308-1313.
8. Capaday, C., and Stein, R.B. 1987. A method for simulating the reflex output of a motoneuron pool. J. Neurosci. Methods, 21: 91-104.
9. Capaday, C., Cody, F.W., and Stein, R.B. 1990. Reciprocal inhibition of soleus motor output in humans during walking and voluntary tonic activity. J. Neurophysiol. 64: 607-616.
10. Chalmers, G.R., and Knutzen, K.M. 2000. Soleus Hoffmann-reflex modulation during walking in healthy elderly and young adults. J. Gerontol. 55: B570-B579.
11. Chalmers, G.R., and Knutzen, K.M. 2002. Soleus H-reflex gain in healthy elderly and young adults when lying, standing, and balancing. J. Gerontol. A. Biol. Sci. Med. Sci. 57: B321-B329.
12. Chase, M.H., Morales, F.R., Boxer, P.A., and Fung, S.J. 1985. Aging of motoneurons and synaptic processes in the cat. Exp. Neurol. 90: 471-478.
13. Crone, C., and Nielsen, J. 1989. Methodological implications of the post activation depression of the soleus H-reflex in man. Exp. Brain Res. 78: 28-32.
14. Crone, C., Hultborn, H., and Jespersen, B. 1985. Reciprocal Ia inhibition from the peroneal nerve to soleus motoneurones with special reference to the size of the test reflex. Exp. Brain Res. 59: 418-422.
15. Crone, C., Hultborn, H., Jespersen, B., and Nielsen, J. 1987. Reciprocal Ia inhibition between ankle flexors and extensors in man. J. Physiol. (Lond.), 389: 163-185.
16. Crone, C., Hultborn, H., Mazieres, L., Morin, C., Nielsen, J., and Pierrot-Deseilligny, E. 1990. Sensitivity of monosynaptic test reflexes to facilitation and inhibition as a function of the test reflex size: a study in man and the cat. Exp. Brain Res. 81: 35-45.
17. Doherty, T.J., Vandervoort, A.A., and Brown, W.F. 1993. Effects of aging on the motor unit: a brief review. Can. J. Appl. Physiol. 18: 331-358.
18. Earles, D., Vardaxis, V., and Koceja, D. 2001. Regulation of motor output between young and elderly subjects. Clin. Neurophysiol. 112: 1273-1279.
19. Edamura, M., Yang, J.F., and Stein, R.B. 1991. Factors that determine the magnitude and time course of human H-reflexes in locomotion. J. Neurosci. 11: 420-427.
20. Falco, F.J., Hennessey, W.J., Goldberg, G., and Braddom, R.L. 1994a. H reflex latency in the healthy elderly. Muscle Nerve, 17: 161-167.
21. Falco, F.J., Hennessey, W.J., Goldberg, G., and Braddom, R.L. 1994b. Standardized nerve conduction studies in the lower limb of the healthy elderly. Am. J. Phys. Med. Rehabil. 73: 168-174.
22. Ferris, D.P., Aagaard, P., Simonsen, E.B., Farley, C.T., and Dyhre-Poulsen, P. 2001. Soleus H-reflex gain in humans walking and running under simulated reduced gravity. J. Physiol. 530: 167-180.
23. Garrett, M., Kerr, T., and Caulfield, B. 1999. Phase-dependent inhibition of H-reflexes during walking in humans is independent of reduction in knee angular velocity. J. Neurophysiol. 82: 747-753.
24. Hiersemenzel, L.P., Curt, A., and Dietz, V. 2000. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Neurology, 54: 1574-1582.
25. Hui-Chan, C.W., and Levin, M.F. 1993. Stretch reflex latencies in spastic hemiparetic subjects are prolonged after transcutaneous electrical nerve stimulation. Can. J. Neurol. Sci. 20: 97-106.
26. Kido, A., Tanaka, N., and Stein, R.B. 2004. Spinal reciprocal inhibition in human locomotion. J. Appl. Physiol. In press.
27. Koceja, D.M., Markus, C.A., and Trimble, M.H. 1995. Postural modulation of the soleus H reflex in young and old subjects. Electroencephalogr. Clin. Neurophysiol. 97: 387-393.
28. Lavoie, B.A., Devanne, H., and Capaday, C. 1997. Differential control of reciprocal inhibition during walking versus postural and voluntary motor tasks in humans. J. Neurophysiol. 78: 429-438.
29. Luff, A.R. 1998. Age-associated changes in the innervation of muscle fibers and changes in the mechanical properties of motor units. Ann. N.Y. Acad. Sci. 854: 92-101.
30. Misiaszek, J.E. 2003. The H-reflex as a tool in neurophysiology: its limitations and uses in understanding nervous system function. Muscle Nerve, 28: 144-160.
31. Morita, H., Shindo, M., Yanagawa, S., Yoshida, T., Momoi, H., and Yanagisawa, N. 1995. Progressive decrease in heteronymous monosynaptic Ia facilitation with human aging. Exp. Brain Res. 104: 167-170.
32. Morita, H., Crone, C., Christenhuis, D., Petersen, N.T., and Nielsen, J.B. 2001. Modulation of presynaptic inhibition and disynaptic reciprocal Ia inhibition during voluntary movement in spasticity. Brain, 124: 826-837.
33. Petersen, N., Morita, H., and Nielsen, J. 1999. Modulation of reciprocal inhibition between ankle extensors and flexors during walking in man. J. Physiol. (Lond.), 520(Pt. 2): 605-619.
34. Rivner, M.H., Swift, T.R., and Malik, K. 2001. Influence of age and height on nerve conduction. Muscle Nerve, 24: 1134-1141.
35. Sabbahi, M.A., and Sedgwick, E.M. 1982. Age-related changes in monosynaptic reflex excitability. J. Gerontol. 37: 24-32.
36. Scaglioni, G., Ferri, A., Minetti, A.E., Martin, A., Van Hoecke, J., Capodaglio, P., Sartorio, A., and Narici, M.V. 2002. Plantar flexor activation capacity and H reflex in older adults: adaptations to strength training. J. Appl. Physiol. 92: 2292-2302.
37. Schieppati, M. 1987. The Hoffmann reflex: a means of assessing spinal reflex excitability and its descending control in man. Prog. Neurobiol. 28: 345-376.
38. Schneider, C., Lavoie, B.A., and Capaday, C. 2000. On the origin of the soleus H-reflex modulation pattern during human walking and its task-dependent differences. J. Neurophysiol. 83: 2881-2890.
39. Trimble, M.H., Brunt, D., Jeon, H.S., and Kim, H.D. 2001. Modulations of soleus H-reflex excitability during gait initiation: central versus peripheral influences. Muscle Nerve, 24: 1371-1379.
40. Yang, J.F., and Stein, R.B. 1990. Phase-dependent reflex reversal in human leg muscles during walking. J. Neurophysiol. 63: 1109-1117.
41. Yang, J.F., and Whelan, P.J. 1993. Neural mechanisms that contribute to cyclical modulation of the soleus H-reflex in walking in humans. Exp. Brain Res. 95: 547-556.
42. Zehr, E.P. 2002. Considerations for use of the Hoffmann reflex in exercise studies. Eur. J. Appl. Physiol. 86: 455-468.
43. Zehr, E.P., and Chua, R. 2000. Modulation of human cutaneous reflexes during rhythmic cyclical arm movement. Exp. Brain Res. 135: 241-250.
44. Zehr, E.P., and Kido, A. 2001. Neural control of rhythmic, cyclical human arm movement: task dependency, nerve specificity and phase modulation of cutaneous reflexes. J. Physiol. (Lond.), 537: 1033-1045.
45. Zehr, E.P., and Stein, R.B. 1999. Interaction of the Jendrassik maneuver with segmental presynaptic inhibition. Exp. Brain Res. 124: 474-480.