Kv7 channels can function without constitutive calmodulin tethering

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Gómez Posada, Juan Camilo ^a   Aivar, Paloma ^a   Alberdi, Araitz ^a   Alaimo, Alessandro ^a   Etxeberría, Ainhoa ^a   Fernández Orth, Juncal ^a   Zamalloa, Teresa ^a   Roura Ferrer, Meritxell ^a   Villace, Patricia ^a   Areso, Pilar ^b   Casis, Oscar ^b   Villarroel, Alvaro ^a  

^a CSIC UPV Unidad de Biofisica UBF   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL KCNQ5; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE CELL EXCITABILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE; CELL STRAIN HEK293; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; CALMODULIN; CELL MEMBRANE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT;

EID: 84856147129     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025508     Document Type: Article

References (37)

1. Schroeder BC, Kubisch C, Stein V, Jentsch TJ, (1998) Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 396: 687-690.
2. Maljevic S, Wuttke TV, Seebohm G, Lerche H, (2010) Kv7 channelopathies. Pflugers Arch 460: 277-288.
3. Yus-Nájera E, Santana-Castro I, Villarroel A, (2002) The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. J Biol Chem 277: 28545-28553.
4. Haitin Y, Attali B, (2008) The C-terminus of Kv7 channels: a multifunctional module. J Physiol 3: 1803-1810.
5. Selyanko AA, Brown DA, (1996) Intracellular calcium directly inhibits potassium M channels in excised membrane patches from rat sympathetic neurons. Neuron 16: 151-162.
6. Gamper N, Shapiro MS, (2003) Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels. J Gen Physiol 122: 17-31.
7. Gamper N, Li Y, Shapiro MS, (2005) Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin. Molecular Biology of the Cell 16: 3538-3551.
8. Zaika O, Tolstykh GP, Jaffe DB, Shapiro MS, (2007) Inositol triphosphate-mediated Ca2+ signals direct purinergic P2Y receptor regulation of neuronal ion channels. J Neurosci 27: 8914-8926.
9. Xia XM, Fakler B, Rivard A, Wayman G, Johnson-Pais T, et al. (1998) Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature 395: 503-507.
10. Wen H, Levitan IB, (2002) Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. J Neurosci 22: 7991-8001.
11. Saimi Y, Kung C, (2002) Calmodulin as an ion channel subunit. Annu Rev Physiol 64: 289-311.
12. Ghosh S, Nunziato DA, Pitt GS, (2006) KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. Circ Res 98: 1048-1054.
13. Shamgar L, Ma LJ, Schmitt N, Haitin Y, Peretz A, et al. (2006) Calmodulin is essential for cardiac IKS channel gating and assembly- Impaired function in long-QT mutations. Circ Res 98: 1055-1063.
14. Alaimo A, Gomez-Posada JC, Aivar P, Etxeberria A, Rodriguez-Alfaro JA, et al. (2009) Calmodulin activation limits the rate of KCNQ2 K+ channel exit from the endoplasmic reticulum. J Biol Chem 284: 20668-20675.
15. Etxeberria A, Aivar P, Rodriguez-Alfaro JA, Alaimo A, Villace P, et al. (2008) Calmodulin regulates the trafficking of KCNQ2 potassium channels. FASEB J 22: 1135-1143.
16. Moulard B, Picard F, Le Hellard S, Agulhon C, Weiland S, et al. (2001) Ion channel variation causes epilepsies. Brain Res Brain Res Rev 36: 275-284.
17. Richards MC, Heron SE, Spendlove HE, Scheffer IE, Grinton B, et al. (2004) Novel mutations in the KCNQ2 gene link epilepsy to a dysfunction of the KCNQ2-calmodulin interaction. J Med Genet 41.
18. Schwake M, Pusch M, Kharkovets T, Jentsch TJ, (2000) Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy. J Biol Chem 275: 13343-13348.
19. Etxeberria A, Santana-Castro I, Regalado MP, Aivar P, Villarroel A, (2004) Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation. J Neurosci 24: 9146-9152.
20. Zaika O, Hernandez CC, Bal M, Tolstykh GP, Shapiro MS, (2008) Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity. Biophys J 95: 5121-5137.
21. Gomez-Posada JC, Etxeberria A, Roura-Ferrer M, Areso P, Masin M, et al. (2010) A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression. J Neurosci 30: 9316-9323.
22. Standley S, Roche KW, McCallum J, Sans N, Wenthold RJ, (2000) PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. Neuron 28: 887-898.
23. Horak M, Wenthold RJ, (2009) Different roles of C-terminal cassettes in the trafficking of full-length NR1 subunits to the cell surface. J Biol Chem 284: 9683-9691.
24. Schönherr R, Lober K, Heinemann SH, (2000) Inhibition of human ether a go-go potassium channels by Ca2+/calmodulin. EMBO J 19: 3263-3271.
25. Suh BC, Hille B, (2008) PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys 37: 175-195.
26. Hughes S, Marsh SJ, Tinker A, Brown DA, (2007) PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons. Pflugers Arch 455: 115-124.
27. Matavel A, Lopes CM, (2009) PKC activation and PIP2 depletion underlie biphasic regulation of IKs by Gq-coupled receptors. J Mol Cell Cardiol 46: 704-712.
28. Nakajo K, Kubo Y, (2005) Protein kinase C shifts the voltage dependence of KCNQ/M channels expressed in Xenopus oocytes. J Physiol 569: 59-74.
29. Lee WS, Ngo-Anh TJ, Bruening-Wright A, Maylie J, Adelman JP, (2003) Small conductance Ca2+-activated K+ channels and calmodulin- Cell surface expression and gating. J Biol Chem 278: 25940-25946.
30. Joiner WJ, Khanna R, Schlichter LC, Kaczmarek LK, (2001) Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels. J Biol Chem 276: 37980-37985.
31. Wang HG, George MS, Kim J, Wang C, Pitt GS, (2007) Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. J Neurosci 27: 9086-9093.
32. Lee JH, Lee J, Choi KY, Hepp R, Lee JY, et al. (2008) Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5. Proc Natl Acad Sci U S A 105: 12575-12580.
33. Suh YH, Pelkey KA, Lavezzari G, Roche PA, Huganir RL, et al. (2008) Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. Neuron 58: 736-748.
34. Shahidullah M, Santarelli LC, Wen H, Levitan IB, (2005) Expression of a calmodulin-binding KCNQ2 potassium channel fragment modulates neuronal M-current and membrane excitability. Proc Natl Acad Sci USA 102: 16454-16459.
35. Ziechner U, Schonherr R, Born AK, Gavrilova-Ruch O, Glaser RW, et al. (2006) Inhibition of human ether a go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. FEBS J 273: 1074-1086.
36. Hernandez CC, Zaika O, Tolstykh GP, Shapiro MS, (2008) Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J Physiol 586: 1811-1821.
37. Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, et al. (2003) AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci 6: 564-571.