Calmodulin activation limits the rate of KCNQ2 K+ channel exit from the endoplasmic reticulum

Journal of Biological Chemistry

Volumn 284, Issue 31, 2009, Pages 20668-20675

  Alaimo, Alessandro ^a   Gómez Posada, Juan Camillo ^a   Aivar, Paloma ^a,c   Etxeberrâ, Ainhoa ^a,d   Rodriguez Alfaro, Jose Angel ^a,e   Areso, Pilar ^b   Villaroel, Alvaro ^a  

^a CSIC UPV Unidad de Biofisica UBF   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c Dirección General de Investigación Científica y Técnica   (Spain)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^e HOSPITAL NACIONAL DE PARAPLÉJICOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPLASMIC RETICULUM; GLUTATHIONE-S-TRANSFERASE; MAMMALIAN CELLS; NOVEL CONCEPT; PLASMA MEMBRANES; PROTEIN TRAFFICKING; STRONG CORRELATION;

CALCIUM; CELL MEMBRANES; MAMMALS; PLASMAS;

CAMS;

ALANINE; ARGININE; ASPARTIC ACID; CALCIUM CHANNEL; CALCIUM ION; CALMODULIN; GLUTAMIC ACID; GLUTATHIONE TRANSFERASE; GLYCINE; ISOLEUCINE; POTASSIUM CHANNEL KCNQ2;

ANIMAL CELL; ARTICLE; BENIGN CHILDHOOD EPILEPSY; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE BINDING; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BINDING SITES; CALMODULIN; CELL LINE; ENDOPLASMIC RETICULUM; HUMANS; KCNQ2 POTASSIUM CHANNEL; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; PROTEIN TRANSPORT; RATS; SPECTROMETRY, FLUORESCENCE; XENOPUS;

MAMMALIA;

EID: 68949094086     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.019539     Document Type: Article

References (18)

1. Wang, H. S., Pan, Z., Shi, W., Brown, B. S., Wymore, R. S., Cohen, I. S., Dixon, J. E., and McKinnon, D. (1998) Science 282, 1890-1893
2. Jentsch, T. J. (2000) Nat. Rev. Neurosci. 1, 21-30
3. Haitin, Y., and Attali, B. (2008) J. Physiol 586, 1803-1810
4. Yus-Nájera, E., Santana-Castro, I., and Villarroel, A. (2002) J. Biol. Chem. 277, 28545-28553
5. Saimi, Y., and Kung, C. (2002) Annu. Rev. Physiol. 64, 289-311
6. Gamper, N., and Shapiro, M. S. (2003) J. Gen. Physiol. 122, 17-31
7. Etxeberria, A., Aivar, P., Rodriguez-Alfaro, J. A., Alaimo, A., Villacé, P., Gómez-Posada, J. C., Areso, P., and Villarroel, A. (2008) FASEB J. 22, 1135-1143
8. Etxeberria, A., Santana-Castro, I., Regalado, M. P., Aivar, P., and Villarroel, A. (2004) J. Neurosci. 24, 9146-9152
9. Manders, E. M., Stap, J., Brakenhoff, G. J., van Driel, R., and Aten, J. A. (1992) J. Cell Sci. 103, 857-862
10. Moulard, B., Picard, F., le Hellard, S., Agulhon, C., Weiland, S., Favre, I., Bertrand, S., Malafosse, A., and Bertrand, D. (2001) Brain Res. Brain Res. Rev. 36, 275-284
11. Richards, M. C., Heron, S. E., Spendlove, H. E., Scheffer, I. E., Grinton, B., Berkovic, S. F., Mulley, J. C., and Davy, A. (2004) J. Med. Genet. 41, e35
12. Schwake, M., Pusch, M., Kharkovets, T., and Jentsch, T. J. (2000) J. Biol. Chem. 275, 13343-13348
13. Bonifacino, J. S., Suzuki, C. K., and Klausner, R. D. (1990) Science 247, 79-82
14. Wen, H., and Levitan, I. B. (2002) J. Neurosci. 22, 7991-8001
15. Bal, M., Zaika, O., Martin, P., and Shapiro, M. S. (2008) J. Physiol 586, 2307-2320
16. Joiner, W. J., Khanna, R., Schlichter, L. C., and Kaczmarek, L. K. (2001) J. Biol. Chem. 276, 37980-37985
17. Lee, W. S., Ngo-Anh, T. J., Bruening-Wright, A., Maylie, J., and Adelman, J. P. (2003) J. Biol. Chem. 278, 25940-25946
18. Schwake, M., Athanasiadu, D., Beimgraben, C., Blanz, J., Beck, C., Jentsch, T. J., Saftig, P., and Friedrich, T. (2006) J. Neurosci. 26, 3757-3766