In vitro and in vivo evaluation of insulin microspheres containing protease inhibitor

Arzneimittel-Forschung/Drug Research

Volumn 61, Issue 1, 2011, Pages 14-22

  Jelvehgari, Mitra ^a,b   Zakeri Milani, Parvin ^a,c   Siahi Shadbad, Mohammad Reza ^a,b   Monajjemzadeh, Farnaz ^a   Nokhodchi, Ali ^d   Azari, Zahra ^a   Valizadeh, Hadi ^a,e  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

^e TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Double emulsion solvent diffusion; Enzymatic degradation; Insulin; Microspheres; Oral delivery; Protease inhibitor

Indexed keywords

ALCOHOL; APROTININ; EUDRAGIT; INSULIN; MICROSPHERE; POTASSIUM CHLORIDE; PROTEINASE INHIBITOR; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; EMULSION; ENZYMATIC DEGRADATION; EVALUATION; EVAPORATION; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; KINETICS; MALE; NONHUMAN; PARTICLE SIZE; PH; POROSITY; RABBIT; RAT; SCANNING ELECTRON MICROSCOPY;

EID: 79951903127     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296163     Document Type: Article

References (40)

1. Cunha AS, Grossiord JL, Puisieux F, Seiller M. Insulin in w/o/w multiple emulsions: preparation characterization and determination of stability towards proteases in vitro. J Microencapsul. 1997;14(3):311-9.
2. Engel RH, Riggi SJ, Fahrenbach MJ. Insulin: intestinal absorption as water-in-oil-in-water emulsions. Nature. 1968;219(5156):856-7.
3. Schilling RJ, Mitra AK. Intestinal mucosal transport of insulin. Pharm Res. 1990;62(1):53-64. (Pubitemid 20216886)
4. Fujii S, Yokoyama T, Ikegaya K, Sato F, Yokoo N. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol. 1985;37(8):545-9. (Pubitemid 15043037)
5. Kidron M, Bar-On H, Berry EM, Ziv E. The absorption of insulin from various regions of the rat intestine. Life Sci. 1982;31(25):2837-41. (Pubitemid 13212452)
6. Ziv E, Lior O, Kidron M. Absorption of protein via the intestinal wall. A quantitative model. Biochem Pharmacol. 1987;36(7):1035-9.
7. Morishita I, Morishita M, Takayama K, Machida Y, Nagai T. Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. Int J Pharm. 1992;78(1):9-16.
8. Morishita M, Morishita I, Takayama K, Machida Y, Nagai T. Novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation.novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation. Int J Pharm. 1992;78(1-3):1-7.
9. Narayani R. Oral delivery of insulin making needles needless. Trends Biomater Artif Organs. 2001;15:12-6. (Pubitemid 33813818)
10. Kimura T, Sato K, Sugimoto K, Tao R, Murakami T, Kurosaki Y, Nakayama T. Oral administration of insulin as poly(vinyl alcohol)-gel spheres in diabetic rats. Biol Pharm Bull. 1996;19(6):897-900. (Pubitemid 26243250)
11. Morishita I, Morishita M, Takayama K, Machida Y, Nagai T. Enteral insulin delivery by microspheres in 3 different formulations using Eudragit-L100 and Eudragit-S100. Int J Pharm. 1993;91(1):29-37. (Pubitemid 23121398)
12. Suzuki A, Morishita M, Kajita M, Takayama K, Isowa K, Chiba Y, et al. Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. J Pharm Sci. 1998;87(10):1196-202. (Pubitemid 28455608)
13. Verstraete M. Clinical application of inhibitors of fibrinolysis. Drugs. 1985;29(3):236-61. (Pubitemid 15144749)
14. Kraeling ME, Ritschel WA. Development of a colonic release capsule dosage form and the absorption of insulin. Methods Find Exp Clin Pharmacol. 1992;14(3):199-209.
15. Morishita I, Morishita M, Machida Y, Nagai T. Controlled release microspheres based on Eudragit L100 for the oral administration of erythromycin. Drug Des Deliv . 1991;7(4):309-19.
16. Jelvehgari M, Valizadeh H, Rezapour M, Nokhodchi A. Control of encapsulation efficiency in polymeric microparticle system of tolmetin. Pharm Dev Technol. 2010;15(1):71-9.
17. Jelvehgari M, Rezapour M, Nokhodchi A, Valizadeh H. Effect of formulation and processing variables on the characteristics of tolmetin microspheres prepared by double emulsion solvent diffusion method. Ind J Pharm Sci. 2010;72(1):72-8.
18. Kilicarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. Int J Pharm. 2003;252(1-2):99-109. (Pubitemid 36126618)
19. Valizadeh H, Zakeri-Milani P, Barzegar-Jalali M, Mohammadi G, Danesh-Bahreini MA, Adibkia K, et al. Preparation and characterization of solid dispersions of piroxicamwith hydrophilic carriers. Drug Dev Ind Pharm. 2007;33(1):45-56. (Pubitemid 46034149)
20. Valizadeh H, Nokhodchi A, Qarakhani N, Zakeri-Milani P, Azarmi S, Hassanzadeh D, et al. Physicochemical characterization of solid dispersions of indomethacin with PEG 6000, Myrj 52, lactose, sorbitol, dextrin, and Eudragit E100. Drug Dev Ind Pharm. 2004;30(3):303-17. (Pubitemid 38451755)
21. Monajjemzadeh F, Hassanzadeh D, Valizadeh H, Siahi- Shadbad MR, Mojarrad JS, Robertson TA, et al. Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets. Eur J Pharm Biopharm. 2009;73(3):404-13.
22. Monajjemzadeh F, Hassanzadeh D, Valizadeh H, Siahi-Shadbad MR, Mojarrad JS, Robertson T, et al. Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies. AAPS PharmSciTech. 2009;10(2):649-59.
23. Barzegar-Jalali M, Nayebi AM, Valizadeh H, Hanaee J, Barzegar-Jalali A, Adibkia K, et al. Evaluation of in vitroin vivo correlation and anticonvulsive effect of carbamazepine after cogrinding with microcrystalline cellulose. J Pharm Pharm Sci. 2006;9(3):307-16. (Pubitemid 46614340)
24. http://www.thermo.com/com/cda/resources/resources-detail/1,2166,13411,00. html; 2009.
25. Shingel KI. Determination of structural peculiarities of dexran, pullulan and gamma-irradiated pullulan by Fouriertransform IR spectroscopy. Carbohydr Res. 2002;337(16):1445-51. (Pubitemid 35245431)
26. Li MG, Lu WL, Wang JC, Zhang X, Zhang H, Wang XQ, et al. Preparation and characterization of insulin nanoparticles employing chitosan and poly(methylmethacrylate/methylmethacrylic acid) copolymer. J Nanosci Nanotechnol. 2006;6(9-10):2874-86. (Pubitemid 44579958)
27. Jain D, Panda AK, Majumdar DK. Eudragit S100 entrapped insulin microspheres for oral delivery. AAPS PharmSciTech. 2005;6(1):E100-7.
28. Dastmalchi S, Garjani A, Maleki N, Sheikhee G, Baghchevan V, Jafari-Azad P, et al. Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique. J Pharm Pharm Sci. 2005;8(2):175-81. (Pubitemid 41519130)
29. Damge C, Maincent P, Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release. 2007;117(2):163-70. (Pubitemid 46161872)
30. Ernest D, Alfert E, Brenda M, Cross BM, McWilliam AAE. CCAC, Guide to the care and use of experimental animals. Canadian Council on Animal Care; 1993.
31. Dong A, Huang P, Caughey WS. Protein secondary structures in water from second-derivative amide I infrared spectra. Biochemistry. 1990;29(13):3303-8. (Pubitemid 20131472)
32. Susi H, Byler DM. Protein structure by Fourier transform infrared spectroscopy: second derivative spectra. Biochem Biophys Res Commun. 1983;115(1):391-7.
33. Rastogi SK, Singh J. Passive and iontophoretic transport enhancement of insulin through porcine epidermis by depilatories: permeability and fourier transform infrared spectroscopy studies. AAPS PharmSci Tech. 2003;4(3):E29.
34. Jameela SR, Suma N, Jayakrishnan A. Protein release from poly(epsilon-caprolactone) microspheres prepared by melt encapsulation and solvent evaporation techniques: a comparative study. J Biomater Sci Polym Ed. 1997;8(6):457-66. (Pubitemid 27196922)
35. Moore JW, Flanner HH. Mathematical comparison of dissolution profiles. PharmTechnol. 1996;20:64-74. (Pubitemid 126450495)
36. Nokhodchi A, Okwudarue ON, Valizadeh H, Momin MN. Cogrinding as a tool to produce sustained release behavior for theophylline particles containing magnesium stearate. AAPS PharmSciTech. 2009;10(4):1243-51.
37. Nokhodchi A, Nazemiyeh H, Khodaparast A, Sorkh-Shahan T, Valizadeh H, Ford JL. An in vitro evaluation of fenugreekmucilage as a potential excipient for oral controlled-releasematrix tablet. Drug Dev Ind Pharm. 2008;34(3):323-9. (Pubitemid 351431205)
38. Barzegar-Jalali M, Adibkia K, Valizadeh H, ShadbadMR, Nokhodchi A, Omidi Y, et al. Kinetic analysis of drug release from nanoparticles. J PharmPharmSci. 2008;11(1):167-77.
39. Azarmi S, Farid J, Nokhodchi A, Bahari-Saravi SM, Valizadeh H. Thermal treating as a tool for sustained release of indomethacin from Eudragit RS and RL matrices. Int J Pharm. 2002;246(1-2):171-7. (Pubitemid 35247989)
40. Paquot N, Scheen AJ, Franchimont P, Lefebvre PJ. The intra-nasal administration of insulin induces significant hypoglycemia and classical counterregulatory hormonal responses in normal man. Diabetes Metab. 1988;14(1):31-6.