Anti-androgen effects of cypermethrin on the amino- and carboxyl-terminal interaction of the androgen receptor

Toxicology

Volumn 292, Issue 2-3, 2012, Pages 99-104

  Hu, Jin Xia ^a   Li, Yan Fang ^a   Pan, Chen ^a   Zhang, Jin Peng ^a   Wang, Hong Mei ^a   Li, Jing ^a   Xu, Li Chun ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Amino and carboxyl terminal interaction; Androgen receptor; Cypermethrin; Two hybrid assay

Indexed keywords

AMINO ACID; ANDROGEN RECEPTOR; ANDROSTANOLONE; CARBOXYL GROUP; CIPERMETHRIN; NILUTAMIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; CYTOTOXICITY; FUSION GENE; GENE VECTOR; GENETIC TRANSFECTION; MOLECULAR INTERACTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; REPORTER GENE;

ANDROGEN ANTAGONISTS; ANDROGEN RECEPTOR ANTAGONISTS; CELL LINE; DIHYDROTESTOSTERONE; HUMANS; IMIDAZOLIDINES; INSECTICIDES; PLASMIDS; PYRETHRINS; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 84856105536     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.11.019     Document Type: Article

References (53)

1. Bateman D.N. Management of pyrethroid exposure. J. Toxicol. Clin. Toxicol. 2000, 38:107-109.
2. Bennett N.C., Gardiner R.A., Hooper J.D., Johnson D.W., Gobe G.C. Molecular cell biology of androgen receptor signalling. Int. J. Biochem. Cell Biol. 2010, 42:813-827.
3. Carlson C.R., Ruppelt A., Tasken K. A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. J. Mol. Biol. 2003, 327:609-618.
4. Centenera M.M., Harris J.M., Tilley W.D., Butler L.M. The contribution of different androgen receptor domains to receptor dimerization and signaling. Mol. Endocrinol. 2008, 22:2373-2382.
5. Chang C.Y., McDonnell D.P. Evaluation of ligand-dependent changes in AR structure using peptide probes. Mol. Endocrinol. 2002, 16:647-660.
6. Choi H., Moon J.K., Liu K.H., Park H.W., Ihm Y.B., Park B.S., Kim J.H. Risk assessment of human exposure to cypermethrin during treatment of mandarin fields. Arch. Environ. Contam. Toxicol. 2006, 50:437-442.
7. Davis-Dao C.A., Tuazon E.D., Sokol R.Z., Cortessis V.K. Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis. J. Clin. Endocrinol. Metab. 2007, 92:4319-4326.
8. Deeb A., Jaaskelainen J., Dattani M., Whitaker H.C., Costigan C., Hughes I.A. A novel mutation in the human androgen receptor suggests a regulatory role for the hinge region in amino-terminal and carboxy-terminal interactions. J. Clin. Endocrinol. Metab. 2008, 93:3691-3696.
9. Elbetieha A., Da'as S.I., Khamas W., Darmani H. Evaluation of the toxic potentials of cypermethrin pesticide on some reproductive and fertility parameters in the male rats. Arch. Environ. Contam. Toxicol. 2001, 41:522-528.
10. Fisher J.S. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004, 127:305-315.
11. Fu L., Liang J.J. Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay. J. Biol. Chem. 2002, 277:4255-4260.
12. Gelmann E.P. Molecular biology of the androgen receptor. J. Clin. Oncol. 2002, 20:3001-3015.
13. Ghali S.A., Gottlieb B., Lumbroso R., Beitel L.K., Elhaji Y., Wu J., Pinsky L., Trifiro M.A. The use of androgen receptor amino/carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivity. J. Clin. Endocrinol. Metab. 2003, 88:2185-2193.
14. Gietz R.D., Triggs-Raine B., Robbins A., Graham K.C., Woods R.A. Identification of proteins that interact with a protein of interest: applications of the yeast two-hybrid system. Mol. Cell Biochem. 1997, 172:67-79.
15. Gray L.E., Ostby J., Furr J., Wolf C.J., Lambright C., Parks L., Veeramachaneni D.N., Wilson V., Price M., Hotchkiss A., Orlando E., Guillette L. Effects of environmental antiandrogens on reproductive development in experimental animals. Hum. Reprod. Update 2001, 7:248-264.
16. He B., Kemppainen J.A., Voegel J.J., Gronemeyer H., Wilson E.M. Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain. J. Biol. Chem. 1999, 274:37219-37225.
17. 2-terminal interaction with the ligand binding domain of the androgen receptor. J. Biol. Chem. 2000, 275:22986-22994.
18. 2- and COOH-terminal interaction. J. Biol. Chem. 2002, 277:25631-25639.
19. He R., Li X. Mammalian two-hybrid assay for detecting protein-protein interactions in vivo. Methods Mol. Biol. 2008, 439:327-337.
20. Holdcraft R.W., Braun R.E. Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development 2004, 131:459-467.
21. Hotchkiss A.K., Ostby J.S., Vandenburgh J.G., Gray L.E. Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat. Environ. Health Perspect. 2002, 110(Suppl. 3):435-439.
22. Hotchkiss A.K., Rider C.V., Furr J., Howdeshell K.L., Blystone C.R., Wilson V.S., Gray L.E. In utero exposure to an AR antagonist plus an inhibitor of fetal testosterone synthesis induces cumulative effects on F1 male rats. Reprod. Toxicol. 2010, 30:261-270.
23. 2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth. Mol. Endocrinol. 2005, 19:350-361.
24. Kelce W.R., Stone C.R., Laws S.C., Gray L.E., Kemppainen J.A., Wilson E.M. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature 1995, 375:581-585.
25. Kemppainen J.A., Langley E., Wong C.I., Bobseine K., Kelce W.R., Wilson E.M. Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone. Mol. Endocrinol. 1999, 13:440-454.
26. Khan N., Asim M., Afaq F., Abu Z.M., Mukhtar H. A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res. 2008, 68:8555-8563.
27. Langley E., Zhou Z.X., Wilson E.M. Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer. J. Biol. Chem. 1995, 270:29983-29990.
28. Lee H.J., Chang C. Recent advances in androgen receptor action. Cell Mol. Life Sci. 2003, 60:1613-1622.
29. Li J., Fu J., Toumazou C., Yoon H.G., Wong J. A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol. Endocrinol. 2006, 20:776-785.
30. Lievens S., Lemmens I., Tavernier J. Mammalian two-hybrids come of age. Trends Biochem. Sci. 2009, 34:579-588.
31. Maier R., Brandner C., Hintner H., Bauer J., Onder K. Construction of a reading frame-independent yeast two-hybrid vector system for site-specific recombinational cloning and protein interaction screening. Biotechniques 2008, 45:235-244.
32. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
33. 2- and COOH-terminal interaction of androgen receptor. Biosci. Biotechnol. Biochem. 2010, 74:1965-1968.
34. Orr C.R., Montie H.L., Liu Y., Bolzoni E., Jenkins S.C., Wilson E.M., Joseph J.D., McDonnell D.P., Merry D.E. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. J. Biol. Chem. 2010, 285:35567-35577.
35. Orton F., Rosivatz E., Scholze M., Kortenkamp A. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ. Health Perspect. 2011, 119:794-800.
36. Rider C.V., Furr J., Wilson V.S., Gray L.E. A mixture of seven antiandrogens induces reproductive malformations in rats. Int. J. Androl. 2008, 31:249-262.
37. Shafer T.J., Meyer D.A. Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity. Toxicol. Appl. Pharmacol. 2004, 196:303-318.
38. Song L.N., Coghlan M., Gelmann E.P. Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor. Mol. Endocrinol. 2004, 18:70-85.
39. Sun H., Xu X.L., Xu L.C., Song L., Hong X., Chen J.F., Cui L.B., Wang X.R. Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay. Chemosphere 2007, 66:474-479.
40. Tamura H., Maness S.C., Reischmann K., Dorman D.C., Gray L.E., Gaido K.W. Androgen receptor antagonism by the organophosphate insecticide fenitrothion. Toxicol. Sci. 2001, 60:56-62.
41. Tanner T.M., Verrijdt G., Rombauts W., Louw A., Hapgood J.P., Claessens F. Anti-androgenic properties of Compound A, an analog of a non-steroidal plant compound. Mol. Cell Endocrinol. 2003, 201:155-164.
42. Thibodeaux G.N., Cowmeadow R., Umeda A., Zhang Z. A tetracycline repressor-based mammalian two-hybrid system to detect protein-protein interactions in vivo. Anal. Biochem. 2009, 386:129-131.
43. Thompson J., Saatcioglu F., Janne O.A., Palvimo J.J. Disrupted amino- and carboxyl-terminal interactions of the androgen receptor are linked to androgen insensitivity. Mol. Endocrinol. 2001, 15:923-935.
44. Wakita K., Tetsu O., McCormick F. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 2001, 61:854-858.
45. Wang H., Wang Q., Zhao X.F., Liu P., Meng X.H., Yu T., Ji Y.L., Zhang H., Zhang C., Zhang Y., Xu D.X. Cypermethrin exposure during puberty disrupts testosterone synthesis via downregulating StAR in mouse testes. Arch. Toxicol. 2010, 84:53-61.
46. Wang H., Wang S.F., Ning H., Ji Y.L., Zhang C., Zhang Y., Yu T., Ma X.H., Zhao X.F., Wang Q., Liu P., Meng X.H., Xu D.X. Maternal cypermethrin exposure during lactation impairs testicular development and spermatogenesis in male mouse offspring. Environ. Toxicol. 2011, 26:382-394.
47. Wilson V.S., Blystone C.R., Hotchkiss A.K., Rider C.V., Gray L.E. Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development. Int. J. Androl. 2008, 31:178-187.
48. Xu L.C., Liu L., Ren X.M., Zhang M.R., Cong N., Xu A.Q., Shao J.H. Evaluation of androgen receptor transcriptional activities of some pesticides in vitro. Toxicology 2008, 243:59-65.
49. Xu L.C., Sun H., Chen J.F., Bian Q., Qian J., Song L., Wang X.R. Evaluation of androgen receptor transcriptional activities of bisphenol A, octylphenol and nonylphenol in vitro. Toxicology 2005, 216:197-203.
50. Xu L.C., Sun H., Chen J.F., Bian Q., Song L., Wang X.R. Androgen receptor activities of p,p'-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay. Toxicol. Lett. 2006, 160:151-157.
51. Yong E.L., Loy C.J., Sim K.S. Androgen receptor gene and male infertility. Hum. Reprod. Update 2003, 9:1-7.
52. Zhang S., Rowlands C., Safe S. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicol. Appl. Pharmacol. 2008, 227:196-206.
53. Zolghadr K., Mortusewicz O., Rothbauer U., Kleinhans R., Goehler H., Wanker E.E., Cardoso M.C., Leonhardt H. A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells. Mol. Cell Proteomics 2008, 7:2279-2287.