Androgen receptor activities of p,p′-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay

Toxicology Letters

Volumn 160, Issue 2, 2006, Pages 151-157

  Xu, Li Chun ^a   Sun, Hong ^a   Chen, Jian Feng ^a   Bian, Qian ^a   Song, Ling ^a   Wang, Xin Ru ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

African monkey kidney cell; Antiandrogenic activity; Human androgen receptor; Pesticide; Reporter gene assay

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ANDROGEN RECEPTOR; ANDROSTANOLONE; FENVALERATE; NILUTAMIDE; PHOXIM;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; EVALUATION; IC 50; KIDNEY CELL; MONKEY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REPRODUCIBILITY; TRANSCRIPTION INITIATION;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; BIOLOGICAL ASSAY; CELL LINE; CERCOPITHECUS; DEXAMETHASONE; DICHLORODIPHENYL DICHLOROETHYLENE; DIHYDROTESTOSTERONE; GENES, REPORTER; HUMANS; IMIDAZOLIDINES; INSECTICIDES; MAMMARY TUMOR VIRUS, MOUSE; MICE; NITRILES; ORGANOTHIOPHOSPHORUS COMPOUNDS; PLASMIDS; PYRETHRINS; RECEPTORS, ANDROGEN; TRANSFECTION;

ANIMALIA;

EID: 27644441836     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.06.016     Document Type: Article

References (38)

1. H.R. Andersen, A.M. Vinggaard, T.H. Rasmussen, I.M. Gjermandsen, and E.C. Bonefeld-Jorgensen Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro Toxicol. Appl. Pharmacol. 179 2002 1 12
2. Q. Bian, L.C. Xu, S.L. Wang, Y.K. Xia, L.F. Tan, J.F. Chen, L. Song, H.C. Chang, and X.R. Wang Study on the relation between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers Occup. Environ. Med. 61 2004 999 1005
3. H. Chen, J. Xiao, G. Hu, J. Zhou, H. Xiao, and X. Wang Estrogenicity of organophosphorus and pyrethroid pesticides J. Toxicol. Environ. Health, Part A 65 2002 1419 1435
4. S.Y. Euling, C. Gennings, E.M. Wilson, J.A. Kemppainen, W.R. Kelce, and C.A. Kimmel Response-surface modeling of the effect of 5alpha- dihydrotestosterone and androgen receptor levels on the response to the androgen antagonist vinclozolin Toxicol. Sci. 69 2002 32 43
5. K.W. Gaido, L.S. Leonard, S. Lovell, J.C. Gould, D. Babai, C.J. Portier, and D.P. McDonnell Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay Toxicol. Appl. Pharmacol. 143 1997 205 212
6. S. Gimeno, A. Gerritsen, and T. Bowmer Feminization of male carp Nature 384 1996 221 222
7. V. Go, J. Garey, M.S. Wolff, and B.G. Pogo Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line Environ. Health Perspect. 107 1999 173 177
8. P.C. Hartig, K.L. Bobseine, B.H. Britt, M.C. Cardon, C.R. Lambright, V.S. Wilson, and L.E. Gray Jr. Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening Toxicol. Sci. 66 2002 82 90
9. T.B. Hayes, A. Collins, M. Lee, M. Mendoza, N. Noriega, A.A. Stuart, and A. Vonk Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses Proc. Natl. Acad. Sci. U.S.A. 99 2002 5476 5480
10. W.R. Kelce, E. Monosson, M.P. Gamcsik, S.C. Laws, and L.E. Gray Jr. Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites Toxicol. Appl. Pharmacol. 126 1994 276 285
11. W.R. Kelce, C.R. Stone, S.C. Laws, L.E. Gray, J.A. Kemppainen, and E.M. Wilson Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist Nature 375 1995 581 585
12. W.R. Kelce, C.R. Lambright, L.E. Gray Jr., and K.P. Roberts Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism Toxicol. Appl. Pharmacol. 142 1997 192 200
13. P.R. Koninckx The physiopathology of endometriosis: pollution and dioxin Gynecol. Obstet. Invest. 47 1999 47 49
14. W. Korner, A.M. Vinggaard, B. Terouanne, R. Ma, C. Wieloch, M. Schlumpf, C. Sultan, and A.M. Soto Interlaboratory comparison of four in vitro assays for assessing androgenic and antiandrogenic activity of environmental chemicals Environ. Health Perspect. 112 2004 695 702
15. T. Kunimatsu, T. Yamada, K. Ose, O. Sunami, Y. Kamita, Y. Okuno, T. Seki, and I. Nakatsuka Lack of (anti-)androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays Regul. Toxicol. Pharmacol. 35 2002 227 237
16. C. Lambright, J. Ostby, K. Bobseine, V. Wilson, A.K. Hotchkiss, P.C. Mann, and L.E. Gray Jr. Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats Toxicol. Sci. 56 2000 389 399
17. D. Miller, B.B. Wheals, N. Beresford, and J.P. Sumpter Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay Environ. Health Perspect. 109 2001 133 138
18. F. Paris, P. Balaguer, B. Terouanne, N. Servant, C. Lacoste, J.P. Cravedi, J.C. Nicolas, and C. Sultan Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell lines Mol. Cell. Endocrinol. 193 2002 43 49
19. L.J. Paulozzi International trends in rates of hypospadias and cryptorchidism Environ. Health Perspect. 107 1999 297 302
20. F. Salazar-Garcia, E. Gallardo-Diaz, P. Ceron-Mireles, D. Loomis, and V.H. Borja-Aburto Reproductive effects of occupational DDT exposure among male malaria control workers Environ. Health Perspect. 112 2004 542 547
21. P. Sohoni, and J.P. Sumpter Several environmental oestrogens are also anti-androgens J. Endocrinol. 158 1998 327 339
22. P. Sohoni, P.A. Lefevre, J. Ashby, and J.P. Sumpter Possible androgenic/anti-androgenic activity of the insecticide fenitrothion J. Appl. Toxicol. 21 2001 173 178
23. S.H. Swan, E.P. Elkin, and L. Fenster The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996 Environ. Health Perspect. 108 2000 961 966
24. M. Takeyoshi, K. Yamasaki, M. Sawaki, M. Nakai, S. Noda, and M. Takatsuki The effeicacy of endocrine disruptor screening tests in detecting anti-estrogenic effects downstream of receptor-ligand interactions Toxicol. Lett. 126 2002 91 98
25. M. Takeyoshi, N. Kuga, and K. Yamasaki Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity Arch. Toxicol. 77 2003 274 279
26. H. Tamura, H. Yoshikawa, K.W. Gaido, S.M. Ross, R.K. DeLisle, W.J. Welsh, and A.M. Richard Interaction of organophosphate pesticides and related compounds with the androgen receptor Environ. Health Perspect. 111 2003 545 552
27. B. Terouanne, B. Tahiri, V. Georget, C. Belon, N. Poujol, C. Avances, F. Orio Jr., P. Balaguer, and C. Sultan A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects Mol. Cell. Endocrinol. 160 2000 39 49
28. V. Turusov, V. Rakitsky, and L. Tomatis Dichlorodiphenyltrichloroethane (DDT): ubiquity, persistence, and risks Environ. Health Perspect. 110 2002 125 128
29. U.S. Environmental Protection Agency, 1998. Endocrine disruptors screening and testing advisory committee (EDSTAC): final report. http://www.epa.gov/scipoly/ocpendo/history/finalrpt.htl.
30. A.M. Vinggaard, E.C. Joergensen, and J.C. Larsen Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals Toxicol. Appl. Pharmacol. 155 1999 150 160
31. A.M. Vinggaard, C. Nellemann, M. Dalgaard, E.B. Jorgensen, and H.R. Andersen Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz Toxicol. Sci. 69 2002 344 353
32. S.M. Waliszewski, O. Carvajal, R.M. Infanzon, P. Trujillo, A.A. Aguirre, and M. Maxwell Levels of organochlorine pesticides in soils and rye plant tissues in a field study J. Agric. Food Chem. 52 2004 7045 7050
33. K.M. Waters, S. Safe, and K.W. Gaido Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice Toxicol. Sci. 63 2001 47 56
34. V.S. Wilson, K. Bobseine, C.R. Lambright, and L.E. Gray Jr. A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists Toxicol. Sci. 66 2002 69 81
35. M.S. Wolff, E. Deych, F. Ojo, and G.S. Berkowitz Predictors of organochlorines in New York City pregnant women, 1998-2001 Environ. Res. 97 2005 170 177
36. Y. Xia, Q. Bian, L. Xu, S. Cheng, L. Song, J. Liu, W. Wu, S. Wang, and X. Wang Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate Toxicology 203 2004 49 60
37. Y. Xia, S. Cheng, Q. Bian, L. Xu, M.D. Collins, H.C. Chang, L. Song, J. Liu, S. Wang, and X. Wang Genotoxic effects on spermatozoa of carbaryl-exposed workers Toxicol. Sci. 85 2005 615 623
38. L.C. Xu, N.Y. Zhan, R. Liu, L. Song, and X.R. Wang Joint action of phoxim and fenvalerate on reproduction in male rats Asian J. Androl. 6 2004 337 341