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Volumn 21, Issue 3, 2012, Pages 536-547

Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; POLYALANINE; POLYGLUTAMINE; POLYLEUCINE; POLYPEPTIDE; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

EID: 84856097529     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr487     Document Type: Article
Times cited : (23)

References (47)
  • 1
    • 0025800526 scopus 로고
    • Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
    • La Spada, A.R., Wilson, E.M., Lubahn, D.B., Harding, A.E. and Fischbeck, K.H. (1991) Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature, 352, 77-79.
    • (1991) Nature , vol.352 , pp. 77-79
    • La Spada, A.R.1    Wilson, E.M.2    Lubahn, D.B.3    Harding, A.E.4    Fischbeck, K.H.5
  • 3
    • 77949775195 scopus 로고    scopus 로고
    • Repeat expansion disease: progress and puzzles in disease pathogenesis
    • La Spada, A.R. and Taylor, J.P. (2010) Repeat expansion disease: progress and puzzles in disease pathogenesis. Nat. Rev. Genet., 11, 247-258.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 247-258
    • La Spada, A.R.1    Taylor, J.P.2
  • 4
    • 0032475877 scopus 로고    scopus 로고
    • Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?
    • Sisodia, S.S. (1998) Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial? Cell, 95, 1-4.
    • (1998) Cell , vol.95 , pp. 1-4
    • Sisodia, S.S.1
  • 7
    • 38349158062 scopus 로고    scopus 로고
    • Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic
    • Epub 18 October 2007
    • Takahashi, T., Kikuchi, S., Katada, S., Nagai, Y., Nishizawa, M. and Onodera, O. (2008) Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic. Hum. Mol. Genet., 17, 345-356. Epub 18 October 2007.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 345-356
    • Takahashi, T.1    Kikuchi, S.2    Katada, S.3    Nagai, Y.4    Nishizawa, M.5    Onodera, O.6
  • 8
    • 78650811716 scopus 로고    scopus 로고
    • Formation and toxicity of soluble polyglutamine oligomers in living cells
    • Lajoie, P. and Snapp, E.L. (2010) Formation and toxicity of soluble polyglutamine oligomers in living cells. PLoS One, 5, e15245.
    • (2010) PLoS One , vol.5
    • Lajoie, P.1    Snapp, E.L.2
  • 11
    • 70350380897 scopus 로고    scopus 로고
    • Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity
    • Epub 18 August 2009
    • Raspe, M., Gillis, J., Krol, H., Krom, S., Bosch, K., van Veen, H. and Reits, E. (2009) Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity. J. Cell Sci., 122, 3262-3271. Epub 18 August 2009.
    • (2009) J. Cell Sci. , vol.122 , pp. 3262-3271
    • Raspe, M.1    Gillis, J.2    Krol, H.3    Krom, S.4    Bosch, K.5    van Veen, H.6    Reits, E.7
  • 12
    • 0034110465 scopus 로고    scopus 로고
    • Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
    • Marsh, J.L., Walker, H., Theisen, H., Zhu, Y.-Z., Fielder, T., Purcell, J. and Thompson, L.M. (2000) Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila. Hum. Mol. Genet., 9, 13-25.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 13-25
    • Marsh, J.L.1    Walker, H.2    Theisen, H.3    Zhu, Y.-Z.4    Fielder, T.5    Purcell, J.6    Thompson, L.M.7
  • 13
    • 17744363882 scopus 로고    scopus 로고
    • The pathogenic agent in Drosophila models of 'polyglutamine' diseases
    • McLeod, C.J., O'Keefe, L.V. and Richards, R.I. (2005) The pathogenic agent in Drosophila models of 'polyglutamine' diseases. Hum. Mol. Genet., 14, 1041-1048.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 1041-1048
    • McLeod, C.J.1    O'Keefe, L.V.2    Richards, R.I.3
  • 14
    • 79953716235 scopus 로고    scopus 로고
    • Muscleblind participates in RNA toxicity of expanded CAG and CUG repeats in Caenorhabditis elegans
    • Epub 17 September 2010
    • Wang, L.C., Chen, K.Y., Pan, H., Wu, C.C., Chen, P.H., Liao, Y.T., Li, C., Huang, M.L. and Hsiao, K.M. (2011) Muscleblind participates in RNA toxicity of expanded CAG and CUG repeats in Caenorhabditis elegans. Cell Mol. Life Sci., 68, 1255-1267. Epub 17 September 2010.
    • (2011) Cell Mol. Life Sci. , vol.68 , pp. 1255-1267
    • Wang, L.C.1    Chen, K.Y.2    Pan, H.3    Wu, C.C.4    Chen, P.H.5    Liao, Y.T.6    Li, C.7    Huang, M.L.8    Hsiao, K.M.9
  • 15
    • 45749147456 scopus 로고    scopus 로고
    • RNA toxicity is a component of ataxin-3 degeneration in Drosophila
    • Epub 30 April 2008
    • Li, L.B., Yu, Z., Teng, X. and Bonini, N.M. (2008) RNA toxicity is a component of ataxin-3 degeneration in Drosophila. Nature, 453, 1107-1111. Epub 30 April 2008.
    • (2008) Nature , vol.453 , pp. 1107-1111
    • Li, L.B.1    Yu, Z.2    Teng, X.3    Bonini, N.M.4
  • 16
    • 79251642948 scopus 로고    scopus 로고
    • Long tract of untranslated CAG repeats is deleterious in transgenic mice
    • Hsu, R.J., Hsiao, K.M., Lin, M.J., Li, C.Y., Wang, L.C., Chen, L.K. and Pan, H. (2011) Long tract of untranslated CAG repeats is deleterious in transgenic mice. PLoS One, 6, e16417.
    • (2011) PLoS One , vol.6
    • Hsu, R.J.1    Hsiao, K.M.2    Lin, M.J.3    Li, C.Y.4    Wang, L.C.5    Chen, L.K.6    Pan, H.7
  • 17
    • 0035475642 scopus 로고    scopus 로고
    • Dynamic mutations: a decade of unstable expanded repeats in human genetic disease
    • Richards, R.I. (2001) Dynamic mutations: a decade of unstable expanded repeats in human genetic disease. Hum. Mol. Genet., 10, 2187-2194.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2187-2194
    • Richards, R.I.1
  • 20
    • 17844394198 scopus 로고    scopus 로고
    • Recent progress in spinocerebellar ataxia type10 (SCA10)
    • Lin, X. and Ashizawa, T. (2005) Recent progress in spinocerebellar ataxia type10 (SCA10). The Cerebellum, 4, 37-42.
    • (2005) The Cerebellum , vol.4 , pp. 37-42
    • Lin, X.1    Ashizawa, T.2
  • 23
    • 58149234573 scopus 로고    scopus 로고
    • Dominant non-coding repeat expansions in human disease
    • Dick, K.A., Margolis, J.M., Day, J.W. and Ranum, L.P. (2006) Dominant non-coding repeat expansions in human disease. Genome Dyn., 1, 67-83.
    • (2006) Genome Dyn , vol.1 , pp. 67-83
    • Dick, K.A.1    Margolis, J.M.2    Day, J.W.3    Ranum, L.P.4
  • 25
    • 79955660764 scopus 로고    scopus 로고
    • An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice
    • Wilburn, B., Rudnicki, D.D., Zhao, J., Weitz, T.M., Cheng, Y., Gu, X., Greiner, E., Park, C.S., Wang, N., Sopher, B.L. et al. (2011) An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice. Neuron, 70, 427-440.
    • (2011) Neuron , vol.70 , pp. 427-440
    • Wilburn, B.1    Rudnicki, D.D.2    Zhao, J.3    Weitz, T.M.4    Cheng, Y.5    Gu, X.6    Greiner, E.7    Park, C.S.8    Wang, N.9    Sopher, B.L.10
  • 27
    • 19444364594 scopus 로고    scopus 로고
    • The other trinucleotide repeat: polyalanine expansion disorders
    • Albrecht, A. and Mundlos, S. (2005) The other trinucleotide repeat: polyalanine expansion disorders. Curr. Opin. Genet. Dev., 15, 285-293.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 285-293
    • Albrecht, A.1    Mundlos, S.2
  • 28
    • 0347418199 scopus 로고    scopus 로고
    • Alanine tracts: the expanding story of human illness and trinucleotide repeats
    • Brown, L.Y. and Brown, S.A. (2004) Alanine tracts: the expanding story of human illness and trinucleotide repeats. Trends Genet., 20, 51-58.
    • (2004) Trends Genet , vol.20 , pp. 51-58
    • Brown, L.Y.1    Brown, S.A.2
  • 30
    • 0034703413 scopus 로고    scopus 로고
    • Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA
    • Calado, A., Tome, F.M., Brais, B., Rouleau, G.A., Kuhn, U., Wahle, E. and Carmo-Fonseca, M. (2000) Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA. Hum. Mol. Genet., 9, 2321-2328.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2321-2328
    • Calado, A.1    Tome, F.M.2    Brais, B.3    Rouleau, G.A.4    Kuhn, U.5    Wahle, E.6    Carmo-Fonseca, M.7
  • 34
    • 33751244242 scopus 로고    scopus 로고
    • Polyalanine and polyserine frameshift products in Huntington's disease
    • Epub 26 June 2006
    • Davies, J.E. and Rubinsztein, D.C. (2006) Polyalanine and polyserine frameshift products in Huntington's disease. J. Med. Genet., 43, 893-896. Epub 26 June 2006.
    • (2006) J. Med. Genet. , vol.43 , pp. 893-896
    • Davies, J.E.1    Rubinsztein, D.C.2
  • 36
    • 33646768641 scopus 로고    scopus 로고
    • A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1
    • Epub 27 April 2006
    • Chartier, A., Benoit, B. and Simonelig, M. (2006) A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1. EMBO J., 25, 2253-2262. Epub 27 April 2006.
    • (2006) EMBO J , vol.25 , pp. 2253-2262
    • Chartier, A.1    Benoit, B.2    Simonelig, M.3
  • 37
  • 38
    • 2442458847 scopus 로고    scopus 로고
    • Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31
    • Groth, A.C., Fish, M., Nusse, R. and Calos, M.P. (2004) Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics, 166, 1775-1782.
    • (2004) Genetics , vol.166 , pp. 1775-1782
    • Groth, A.C.1    Fish, M.2    Nusse, R.3    Calos, M.P.4
  • 39
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A.H. and Perrimon, N. (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development, 118, 401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 41
    • 33847660443 scopus 로고    scopus 로고
    • An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
    • Epub 22 February 2007
    • Bischof, J., Maeda, R.K., Hediger, M., Karch, F. and Basler, K. (2007) An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl Acad. Sci. USA, 104, 3312-3317. Epub 22 February 2007.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 3312-3317
    • Bischof, J.1    Maeda, R.K.2    Hediger, M.3    Karch, F.4    Basler, K.5
  • 42
    • 0028147879 scopus 로고
    • Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
    • Lin, D.M. and Goodman, C.S. (1994) Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron, 13, 507-523.
    • (1994) Neuron , vol.13 , pp. 507-523
    • Lin, D.M.1    Goodman, C.S.2
  • 43
    • 14844361744 scopus 로고    scopus 로고
    • Comparative analysis of the cytotoxicity of homopolymeric amino acids
    • Epub 27 January 2005
    • Oma, Y., Kino, Y., Sasagawa, N. and Ishiura, S. (2005) Comparative analysis of the cytotoxicity of homopolymeric amino acids. Biochim. Biophys. Acta, 1748, 174-179. Epub 27 January 2005.
    • (2005) Biochim. Biophys. Acta , vol.1748 , pp. 174-179
    • Oma, Y.1    Kino, Y.2    Sasagawa, N.3    Ishiura, S.4
  • 44
    • 33745545413 scopus 로고    scopus 로고
    • Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8
    • Epub 25 June 2006
    • Moseley, M.L., Zu, T., Ikeda, Y., Gao, W., Mosemiller, A.K., Daughters, R.S., Chen, G., Weatherspoon, M.R., Clark, H.B., Ebner, T.J. et al. (2006) Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8. Nat. Genet., 38, 758-769. Epub 25 June 2006.
    • (2006) Nat. Genet. , vol.38 , pp. 758-769
    • Moseley, M.L.1    Zu, T.2    Ikeda, Y.3    Gao, W.4    Mosemiller, A.K.5    Daughters, R.S.6    Chen, G.7    Weatherspoon, M.R.8    Clark, H.B.9    Ebner, T.J.10
  • 45
    • 27644525713 scopus 로고    scopus 로고
    • Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF
    • Cho, D.H., Thienes, C.P., Mahoney, S.E., Analau, E., Filippova, G.N. and Tapscott, S.J. (2005) Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF. Mol. Cell, 20, 483-489.
    • (2005) Mol. Cell , vol.20 , pp. 483-489
    • Cho, D.H.1    Thienes, C.P.2    Mahoney, S.E.3    Analau, E.4    Filippova, G.N.5    Tapscott, S.J.6
  • 47
    • 77953887860 scopus 로고    scopus 로고
    • Partners in crime: bidirectional transcription in unstable microsatellite disease
    • Epub 4 April 2010
    • Batra, R., Charizanis, K. and Swanson, M.S. (2010) Partners in crime: bidirectional transcription in unstable microsatellite disease. Hum. Mol. Genet., 19, R77-R82. Epub 4 April 2010.
    • (2010) Hum. Mol. Genet. , vol.19
    • Batra, R.1    Charizanis, K.2    Swanson, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.