ER stress is the initial response to polyglutamine toxicity in PC12 cells

Biochemical and Biophysical Research Communications

Volumn 377, Issue 2, 2008, Pages 550-555

  Nakayama, Hitoshi ^a   Hamada, Masashi ^b   Fujikake, Nobuhiro ^c   Nagai, Yoshitaka ^c   Zhao, Jing ^a   Hatano, Osamu ^a   Shimoke, Koji ^b   Isosaki, Minoru ^a   Yoshizumi, Masanori ^a   Ikeuchi, Toshihiko ^b  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

ER stress; PC12 cells; Polyglutamine; Proteasome; Ubiquitin; UPS

Indexed keywords

CASPASE 3; HYBRID PROTEIN; LACTACYSTIN; POLYGLUTAMINE; PROTEASOME; STRESS ACTIVATED PROTEIN KINASE; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; IMMUNOREACTIVITY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PEPTIDES; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 55649099810     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.006     Document Type: Article

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