ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2328-2341

  Majka, Jerzy ^a   Alford, Brian ^a   Ausio, Juan ^c   Finn, Ron M ^c   McMurray, Cynthia T ^a,b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATP BINDING; ATP HYDROLYSIS; ENDONUCLEASES; EXONUCLEASE; EXONUCLEASE ACTIVITY; MOLECULAR SWITCHES; NUCLEASE ACTIVITY; OPEN-CLOSED TRANSITION; STRUCTURAL STATE;

BIOCHEMISTRY; BIOLOGY;

HYDROLYSIS;

ENDONUCLEASE; EXONUCLEASE; MRE11 PROTEIN; RAD50 PROTEIN;

ARTICLE; ATP HYDROLYSIS; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME CONFORMATION; HYDROLYSIS; INTERACTIONS WITH NUCLEIC ACID; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ADENOSINE TRIPHOSPHATE; ARCHAEAL PROTEINS; DNA, ARCHAEAL; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; HYDROLYSIS; MULTIENZYME COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PYROCOCCUS FURIOSUS; RECOMBINATION, GENETIC;

EID: 84856074733     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.307041     Document Type: Article

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