Akt/eNOS pathway activation in endothelium-dependent relaxation is preserved in aortas from female, but not from male, type 2 diabetic mice

Pharmacological Research

Volumn 65, Issue 1, 2012, Pages 56-65

  Taguchi, Kumiko ^a   Matsumoto, Takayuki ^a   Kamata, Katsuo ^a   Kobayashi, Tsuneo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Akt eNOS pathway; Endothelial dysfunction; Gender difference; Type 2 diabetes

Indexed keywords

CLONIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; INSULIN; PROTEIN KINASE B; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; FEMALE; GLUCOSE BLOOD LEVEL; HYPERTENSION; INSULIN BLOOD LEVEL; MALE; MEDIATOR RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; VASODILATATION;

ANIMALS; AORTA; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SEX FACTORS; SIGNAL TRANSDUCTION; VASODILATION; VASODILATOR AGENTS;

EID: 84856020964     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.08.009     Document Type: Article

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