Endothelial function, vascular reactivity and gender differences in the cardiovascular system

Cardiovascular Research

Volumn 53, Issue 3, 2002, Pages 597-604

  Sader, Mark A ^a,b   Celermajer, David S ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Atherosclerosis; Endothelial function; Gender

Indexed keywords

ANDROGEN; CELL ADHESION MOLECULE; CYTOKINE; ENDOTHELIAL CELL GROWTH FACTOR; ENDOTHELIN; ESTROGEN; NITRIC OXIDE; PLASMINOGEN ACTIVATOR INHIBITOR; PROSTACYCLIN; VON WILLEBRAND FACTOR;

AGE; ANDROGEN BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR SYSTEM; ENDOTHELIUM; ESTROGEN BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; HORMONAL REGULATION; HUMAN; MALE; MENSTRUAL CYCLE; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE;

ADULT; AGED; AGING; ANDROGENS; CARDIOVASCULAR PHYSIOLOGY; ENDOTHELIUM, VASCULAR; ESTROGENS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MALE; MENOPAUSE; MENSTRUATION; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; SEX;

EID: 0037084053     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00473-4     Document Type: Review

References (85)

1. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents
2. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
3. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
4. Endothelial dysfunction: Does it matter? Is it reversible?
5. The pathogenesis of atherosclerosis: A perspective for the 1990s
6. Close relationship of endothelial function in the human coronary and peripheral circulations
7. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease
8. Choices among the possible reaction routes catalyzed by thrombin
9. Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin
10. Cell biology of endothelial cells
11. Endothelium and control of vascular function
12. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
13. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
14. Role of endothelium in the maintenance of low pulmonary vascular tone in normal children
15. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
16. Crucial role of endothelium in the vasodilator response to increased flow in vivo
17. Endothelium-derived relaxing factor alters calcium fluxes in rabbit aorta: A cyclic guanosine monophosphate-mediated effect
18. Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function
19. Endometrial vascular smooth muscle oestrogen and progesterone receptor distribution in women with and without menorrhagia
20. Specific estrogen binding sites in human lymphoid cells and thymic cells
21. Androgen and estrogen receptors are present in primary cultures of human synovial macrophages
22. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids
23. The protective effects of estrogen on the cardiovascular system
24. Human vascular smooth muscle cells contain functional estrogen receptor
25. Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall
26. Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis
27. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): Testosterone regulates AR expression
28. Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene
29. Estrogen increases endothelial nitric oxide by a receptor-mediated system
30. Induction of calcium-dependent nitric oxide synthases by sex hormones
31. Vascular endothelial growth factor is up-regulated in vitro and in vivo by androgens
32. Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism
33. + channels
34. 2+ mobilization
35. Antioxidant potential of specific estrogens on lipid peroxidation
36. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension
37. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
38. Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia
39. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo
40. Testing for endothelial dysfunction
41. Nitric oxide as a challenge for the clinical chemistry laboratory
42. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion
43. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
44. Extraskeletal effects of estrogen and prevention of atherosclerosis
45. Constantly low HDL-cholesterol concentration relates to endothelial dysfunction and increased in vivo LDL-oxidation in healthy young men
46. Normal ranges for brachial artery flow-mediated dilation: A non-invasive ultrasound test of arterial endothelial function
47. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension
48. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans
49. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women
50. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle
51. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women
52. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women
53. 17beta-estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease
54. Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease
55. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women
56. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women
57. Hormone replacement therapy is associated with improved arterial physiology in healthy post-menopausal women
58. Combined hormone replacement therapy does not protect women against the age-related decline in endothelium-dependent vasomotor function
59. Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal women
60. In search of optimal long-term female hormone replacement: The potential of selective estrogen receptor modulators
61. Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism
62. Raloxifene improves brachial artery and microcirculatory flow-mediated dilation in healthy post-menopausal women
63. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques
64. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women
65. Gender difference in improvement of endothelium-dependent vasodilation after estrogen supplementation
66. Acute administration of 17beta-oestradiol does not improve endothelium-dependent vasodilatation in young men
67. Arterial reactivity is enhanced in genetic males taking high dose estrogens
68. Long-term estrogen therapy improves vascular function in male to female transsexuals
69. Oestradiol improves arterial endothelial function in healthy men receiving testosterone
70. Tamoxifen effects on endothelial function and cardiovascular risk factors in men with advanced atherosclerosis
71. Aromatase inhibition alters vascular reactivity and arterial compliance in men: A possible vascular role for endogenous sex hormones in males
72. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease
73. Testosterone relaxes rabbit coronary arteries and aorta
74. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo
75. Chronic treatment with the anabolic steroid, nandrolone, inhibits vasodilator responses in rabbit aorta
76. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men
77. Androgenic anabolic steroids and arterial structure and function in male bodybuilders
78. Effects of testosterone on arterial reactivity in hypogonadal men
79. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and the quality of life in older men with partial androgen deficiency
80. Vascular reactivity is impaired in genetic females taking high-dose androgens
81. Evidence that parenteral testosterone therapy may improve endothelium-dependent and -independent vasodilation in postmenopausal women already receiving estrogen
82. Polycystic ovary syndrome is associated with endothelial dysfunction
83. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization
84. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
85. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction