Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 265-274

  Ram Reddy, T ^a,b   Rajeshwar Reddy, G ^a   Srinivasula Reddy, L ^a,b   Jammula, Subbarao ^a   Lingappa, Y ^b   Kapavarapu, Ravikumar ^c   Meda, Chandana Lakshmi T ^c   Parsa, Kishore V L ^c   Pal, Manojit ^c  

^a DR REDDY'S LABORATORIES LTD   (India)

^b SRI VENKATESWARA UNIVERSITY   (India)

^c INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

keto ester; Aldehyde; Malononitrile; Montmorillonite K 10; PDE4; Pyridine

Indexed keywords

ALCOHOL; CYANO PYRIDINE DERIVATIVE; ETHYL 4 (4 BROMO 2,6 DIFLUOROPHENYL) 5 CYANO 6 ETHOXY 2 METHYLNICOTINATE; ETHYL 4 (4 BROMOPHENYL) 5 CYANO 6 ETHOXY 2 METHYLNICOTINATE; ETHYL 5 CYANO 4 (2,4 DIFLUOROPHENYL) 6 ETHOXY 2 METHYLNICOTINATE; ETHYL 5 CYANO 4 (2,4 DIFLUOROPHENYL) 6 METHOXY 2 METHYLNICOTINATE; ETHYL 5 CYANO 4 (4 FLUOROPHENYL) 6 METHOXY 2 METHYLNICOTINATE; ETHYL 5 CYANO 6 ETHOXY 2 METHYL 4 PHENYLNICOTINATE; ETHYL 5 CYANO 6 ETHOXY 4 (4 FLUOROPHENYL) 2 METHYLNICOTINATE; ETHYL 5 CYANO 6 ETHOXY 4 (4 METHOXYPHENYL) 2 METHYLNICOTINATE; ETHYL 5 CYANO 6 METHOXY 2 METHYL 4 [4 (TRIFLUOROMETHYL)PHENYL]NICOTINATE; ETHYL 5 CYANO 6 METHOXY 2 METHYL 4 PHENYLNICOTINATE; METHYL 4 (4 BROMO 2,6 DIFLUOROPHENYL) 5 CYANO 6 METHOXY 2 METHYLNICOTINATE; METHYL 4 (4 BROMOPHENYL) 5 CYANO 6 ETHOXY 2 METHYLNICOTINATE; METHYL 5 CYANO 4 (2,4 DIFLUOROPHENYL) 6 METHOXY 2 METHYLNICOTINATE; METHYL 5 CYANO 4 (4 METHOXYPHENYL) 6 METHOXY 2 METHYLNICOTINATE; METHYL 5 CYANO 6 METHOXY 2 METHYL 4 [4 (TRIFLUOROMETHYL)PHENYL]NICOTINATE; METHYL 5 CYANO 6 METHOXY 2 METHYL 4 PHENYLNICOTINATE; METHYL 5 CYANO 6 METHOXY 4 (4 METHOXYPHENYL) 2 METHYLNICOTINATE; MONTMORILLONITE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; COMPUTER MODEL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HECK REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SONOGASHIRA REACTION; SUZUKI REACTION;

BENTONITE; CATALYSIS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; GREEN CHEMISTRY TECHNOLOGY; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PHOSPHODIESTERASE 4 INHIBITORS; PYRIDINES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84856013144     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.024     Document Type: Article

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