Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 2, 2012, Pages 588-593

  Reeves, Matthew B ^a   Breidenstein, Abagail ^a   Compton, Teresa ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN B; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN MCL 1; SHORT HAIRPIN RNA;

ARTICLE; BONE MARROW CELL; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; HEMATOPOIETIC CELL; HUMAN CYTOMEGALOVIRUS; LATENT PERIOD; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STIMULATION; UPREGULATION; VIRUS ENTRY; VIRUS GENE; VIRUS INFECTION;

APOPTOSIS; BLOTTING, WESTERN; BUTADIENES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA PRIMERS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION REGULATION; GENETIC VECTORS; HUMANS; IMIDAZOLES; LENTIVIRUS; MYELOID CELLS; NITRILES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

HUMAN HERPESVIRUS 5;

EID: 84856011036     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114966108     Document Type: Article

References (52)

1. Ho M (1990) Epidemiology of cytomegalovirus infections. Rev Infect Dis 12(suppl 7): S701-S710.
2. Limaye AP, et al. (2008) Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 300:413-422. (Pubitemid 352040253)
3. Legendre C, Pascual M (2008) Improving outcomes for solid-organ transplant recipients at risk from cytomegalovirus infection: Late-onset disease and indirect consequences. Clin Infect Dis 46:732-740. (Pubitemid 351321558)
4. Cheeran MC, Lokensgard JR, Schleiss MR (2009) Neuropathogenesis of congenital cytomegalovirus infection: Disease mechanisms and prospects for intervention. Clin Microbiol Rev 22:99-126.
5. Sinzger C, Digel M, Jahn G (2008) Cytomegalovirus cell tropism. Curr Top Microbiol Immunol 325:63-83.
6. Sinclair J, Sissons P (2006) Latency and reactivation of human cytomegalovirus. J Gen Virol 87:1763-1779. (Pubitemid 43985862)
7. Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T (1998) Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays. Proc Natl Acad Sci USA 95:14470-14475. (Pubitemid 28549391)
8. Simmen KA, et al. (2001) Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B. Proc Natl Acad Sci USA 98: 7140-7145. (Pubitemid 32567916)
9. Boehme KW, Compton T (2004) Innate sensing of viruses by toll-like receptors. J Virol 78:7867-7873. (Pubitemid 38944272)
10. Johnson RA, Wang X, Ma XL, Huong SM, Huang ES (2001) Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling. J Virol 75:6022-6032. (Pubitemid 32553133)
11. Boyle KA, Pietropaolo RL, Compton T (1999) Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway. Mol Cell Biol 19:3607-3613. (Pubitemid 29193820)
12. Johnson RA, Huong SM, Huang ES (2000) Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: A novel mechanism for activation of p38. J Virol 74:1158-1167. (Pubitemid 30044065)
13. Compton T, et al. (2003) Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77:4588-4596. (Pubitemid 36402808)
14. Fortunato EA, McElroy AK, Sanchez I, Spector DH (2000) Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus. Trends Microbiol 8: 111-119. (Pubitemid 30155486)
15. Alwine JC (2008) Modulation of host cell stress responses by human cytomegalovirus. Curr Top Microbiol Immunol 325:263-279.
16. McCormick AL (2008) Control of apoptosis by human cytomegalovirus. Curr Top Microbiol Immunol 325:281-295.
17. Reeves MB, Davies AA, McSharry BP, Wilkinson GW, Sinclair JH (2007) Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science 316:1345-1348. (Pubitemid 46871656)
18. Opferman JT, et al. (2005) Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307:1101-1104. (Pubitemid 40262114)
19. Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci USA 90:3516-3520. (Pubitemid 23111397)
20. Warr MR, Shore GC (2008) Unique biology of Mcl-1: Therapeutic opportunities in cancer. Curr Mol Med 8:138-147. (Pubitemid 351516833)
21. Chan G, et al. (2010) PI3K-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J Immunol 184:3213-3222.
22. Isaacson MK, Juckem LK, Compton T (2008) Virus entry and innate immune activation. Curr Top Microbiol Immunol 325:85-100.
23. Weinshenker BG, Wilton S, Rice GP (1988) Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in a monocytic cell line. J Immunol 140:1625-1631.
24. Everett H, McFadden G (1999) Apoptosis: An innate immune response to virus infection. Trends Microbiol 7:160-165. (Pubitemid 29229902)
25. Meyaard L, et al. (1992) Programmed death of T cells in HIV-1 infection. Science 257: 217-219.
26. Ameisen JC, Capron A (1991) Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol Today 12:102-105.
27. Galvan V, Roizman B (1998) Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Proc Natl Acad Sci USA 95:3931-3936.
28. Deng L, et al. (2008) Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase 3-dependent pathway. J Virol 82:10375-10385. (Pubitemid 352691171)
29. Boehme KW, Guerrero M, Compton T (2006) Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol 177:7094-7102. (Pubitemid 44715077)
30. Tang SC, et al. (2007) Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA 104:13798-13803.
31. Sabroe I, Dower SK, Whyte MK (2005) The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis 41(suppl 7): S421-S426. (Pubitemid 41598299)
32. Chan G, Guilbert LJ (2006) Ultraviolet-inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a Toll-like receptor-2 and tumour necrosis factor-alpha dependent manner. J Pathol 210:111-120. (Pubitemid 44288187)
33. Aravalli RN, Hu S, Lokensgard JR (2007) Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia. J Neuroinflammation 4:11.
34. Soroceanu L, Akhavan A, Cobbs CS (2008) Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection. Nature 455: 391-395.
35. Isaacson MK, Feire AL, Compton T (2007) Epidermal growth factor receptor is not required for human cytomegalovirus entry or signaling. J Virol 81:6241-6247. (Pubitemid 46878030)
36. Wang X, Huong SM, Chiu ML, Raab-Traub N, Huang ES (2003) Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus. Nature 424:456-461. (Pubitemid 36917497)
37. Feire AL, Koss H, Compton T (2004) Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. Proc Natl Acad Sci USA 101:15470-15475. (Pubitemid 39441565)
38. Wang X, Huang DY, Huong SM, Huang ES (2005) Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. Nat Med 11:515-521. (Pubitemid 40685974)
39. Slobedman B, et al. (2004) Impact of human cytomegalovirus latent infection on myeloid progenitor cell gene expression. J Virol 78:4054-4062. (Pubitemid 38437212)
40. Smith MS, Bentz GL, Smith PM, Bivins ER, Yurochko AD (2004) HCMV activates PI(3)K in monocytes and promotes monocyte motility and transendothelial migration in a PI (3)K-dependent manner. J Leukoc Biol 76:65-76. (Pubitemid 38857173)
41. Aichberger KJ, et al. (2005) Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): Evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides. Blood 105:3303-3311.
42. Goldfarb AN (2005) ERK expands its empire. Leuk Res 29:1235-1236.
43. Spyridonidis A, et al. (1998) Purging of mammary carcinoma cells during ex vivo culture of CD34+ hematopoietic progenitor cells with recombinant immunotoxins. Blood 91:1820-1827. (Pubitemid 28110350)
44. Compton T (2000) Analysis of cytomegalovirus ligands, receptors and the entry pathway. Methods in Molecular Medicine: Cytomegalovirus Protocols, ed Sinclair J (Humana Press, Totowa, NJ), pp 53-65.
45. Ohlin M, Sundqvist VA, Mach M, Wahren B, Borrebaeck CA (1993) Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. J Virol 67:703-710. (Pubitemid 23032046)
46. Drobyski WR, et al. (1991) Phase I study of safety and pharmacokinetics of a human anticytomegalovirus monoclonal antibody in allogeneic bone marrow transplant recipients. Transplantation 51:1190-1196.
47. Britt WJ, Mach M (1996) Human cytomegalovirus glycoproteins. Intervirology 39: 401-412. (Pubitemid 27174142)
48. Reeves MB, MacAry PA, Lehner PJ, Sissons JG, Sinclair JH (2005) Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers. Proc Natl Acad Sci USA 102:4140-4145. (Pubitemid 40388569)
49. Rosenberg B, Vancamp L, Krigas T (1965) Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 205:698-699.
50. Barry MA, Behnke CA, Eastman A (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40:2353-2362. (Pubitemid 20373997)
51. Moffat J, et al. (2006) A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124:1283-1298.
52. Wiederschain D, et al. (2009) Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle 8:498-504.