-
2
-
-
33645976174
-
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
-
Calvisi, D. F., Ladu, S., Gorden, A., Farina, M., Conner, E. A., Lee, J. S., Factor, V. M. and Thorgeirsson, S. S. (2006). Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 130, 1117-1128.
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
Farina, M.4
Conner, E.A.5
Lee, J.S.6
Factor, V.M.7
Thorgeirsson, S.S.8
-
3
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo, A., Ma, L., Teruya-Feldstein, J., Rojo, F., Salmena, L., Alimonti, A., Egia, A., Sasaki, A. T., Thomas, G., Kozma, S. C. et al. (2008). Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J. Clin. Invest. 118, 3065-3074.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
Egia, A.7
Sasaki, A.T.8
Thomas, G.9
Kozma, S.C.10
-
4
-
-
34547942530
-
Targeting oncogenic Ras
-
DOI 10.1101/gad.1587907
-
Diaz-Flores, E. and Shannon, K. (2007). Targeting oncogenic Ras. Genes Dev. 21, 1989-1992. (Pubitemid 47267284)
-
(2007)
Genes and Development
, vol.21
, Issue.16
, pp. 1989-1992
-
-
Diaz-Flores, E.1
Shannon, K.2
-
5
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward, J. (2003). Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
6
-
-
47649087684
-
Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish
-
Emelyanov, A. and Parinov, S. (2008). Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish. Dev. Biol. 320, 113-121.
-
(2008)
Dev. Biol.
, vol.320
, pp. 113-121
-
-
Emelyanov, A.1
Parinov, S.2
-
7
-
-
33751318230
-
Trans-kingdom transposition of the maize Dissociation element
-
DOI 10.1534/genetics.106.061184
-
Emelyanov, A., Gao, Y., Naqvi, N. I. and Parinov, S. (2006). Trans-kingdom transposition of the maize dissociation element. Genetics 174, 1095-1104. (Pubitemid 44808285)
-
(2006)
Genetics
, vol.174
, Issue.3
, pp. 1095-1104
-
-
Emelyanov, A.1
Gao, Y.2
Naqvi, N.I.3
Parinov, S.4
-
8
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman, J. A., Chen, L., Tan, X., Crosby, K., Guimaraes, A. R., Upadhyay, R., Maira, M., McNamara, K., Perera, S. A., Song, Y. et al. (2008). Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat. Med. 14, 1351-1356.
-
(2008)
Nat. Med.
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
Maira, M.7
McNamara, K.8
Perera, S.A.9
Song, Y.10
-
9
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: From genes to environment
-
DOI 10.1038/nrc1934, PII NRC1934
-
Farazi, P. A. and DePinho, R. A. (2006). Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 6, 674-687. (Pubitemid 44286000)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.9
, pp. 674-687
-
-
Farazi, P.A.1
DePinho, R.A.2
-
10
-
-
55949086924
-
Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis
-
Gomaa, A. I., Khan, S. A., Toledano, M. B., Waked, I. and Taylor-Robinson, S. D. (2008). Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J. Gastroenterol. 14, 4300-4308.
-
(2008)
World J. Gastroenterol.
, vol.14
, pp. 4300-4308
-
-
Gomaa, A.I.1
Khan, S.A.2
Toledano, M.B.3
Waked, I.4
Taylor-Robinson, S.D.5
-
11
-
-
0041883654
-
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
-
DOI 10.1016/S1535-6108(03)00191-0
-
Guerra, C., Mijimolle, N., Dhawahir, A., Dubus, P., Barradas, M., Serrano, M., Campuzano, V. and Barbacid, M. (2003). Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4, 111-120. (Pubitemid 37040827)
-
(2003)
Cancer Cell
, vol.4
, Issue.2
, pp. 111-120
-
-
Guerra, C.1
Mijimolle, N.2
Dhawahir, A.3
Dubus, P.4
Barradas, M.5
Serrano, M.6
Campuzano, V.7
Barbacid, M.8
-
12
-
-
68049113683
-
Activation of phosphatidylinositol-3′-kinase/AKT signaling is essential in hepatoblastoma survival
-
Hartmann, W., Küchler, J., Koch, A., Friedrichs, N., Waha, A., Endl, E., Czerwitzki, J., Metzger, D., Steiner, S., Wurst, P. et al. (2009). Activation of phosphatidylinositol-3′-kinase/AKT signaling is essential in hepatoblastoma survival. Clin. Cancer Res. 15, 4538-4545.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 4538-4545
-
-
Hartmann, W.1
Küchler, J.2
Koch, A.3
Friedrichs, N.4
Waha, A.5
Endl, E.6
Czerwitzki, J.7
Metzger, D.8
Steiner, S.9
Wurst, P.10
-
13
-
-
0037434880
-
In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio)
-
DOI 10.1016/S0014-5793(03)00157-1
-
Her, G. M., Chiang, C. C., Chen, W. Y. and Wu, J. L. (2003). In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio). FEBS Lett. 538, 125-133. (Pubitemid 36287437)
-
(2003)
FEBS Letters
, vol.538
, Issue.1-3
, pp. 125-133
-
-
Her, G.M.1
Chiang, C.-C.2
Chen, W.-Y.3
Wu, J.-L.4
-
14
-
-
53649103839
-
Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish
-
Korzh, S., Pan, X., Garcia-Lecea, M., Winata, C. L., Pan, X., Wohland, T., Korzh, V. and Gong, Z. (2008). Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Dev. Biol. 8, 84.
-
(2008)
BMC Dev. Biol.
, vol.8
, pp. 84
-
-
Korzh, S.1
Pan, X.2
Garcia-Lecea, M.3
Winata, C.L.4
Pan, X.5
Wohland, T.6
Korzh, V.7
Gong, Z.8
-
15
-
-
30544433311
-
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
-
DOI 10.1038/nbt1169, PII NBT1169
-
Lam, S. H., Wu, Y. L., Vega, V. B., Miller, L. D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K. R., Lee, S., Mathavan, S. et al. (2006). Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat. Biotechnol. 24, 73-75. (Pubitemid 43083168)
-
(2006)
Nature Biotechnology
, vol.24
, Issue.1
, pp. 73-75
-
-
Siew, H.L.1
Yi, L.W.2
Vega, V.B.3
Miller, L.D.4
Spitsbergen, J.5
Tong, Y.6
Zhan, H.7
Govindarajan, K.R.8
Lee, S.9
Mathavan, S.10
Murthy, K.R.K.11
Buhler, D.R.12
Liu, E.T.13
Gong, Z.14
-
16
-
-
79955431601
-
Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C
-
HALT-C Trial Group
-
Lambrecht, R. W., Sterling, R. K., Naishadham, D., Stoddard, A. M., Rogers, T., Morishima, C., Morgan, T. R., Bonkovsky, H. L. and HALT-C Trial Group (2011). Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C. Gastroenterology 140, 1490-1500.
-
(2011)
Gastroenterology
, vol.140
, pp. 1490-1500
-
-
Lambrecht, R.W.1
Sterling, R.K.2
Naishadham, D.3
Stoddard, A.M.4
Rogers, T.5
Morishima, C.6
Morgan, T.R.7
Bonkovsky, H.L.8
-
17
-
-
0347785481
-
Myc-induced T cell leukemia in transgenic zebrafish
-
DOI 10.1126/science.1080280
-
Langenau, D. M., Traver, D., Ferrando, A. A., Kutok, J. L., Aster, J. C., Kanki, J. P., Lin, S., Prochownik, E., Trede, N. S., Zon, L. I. et al. (2003). Myc-induced T cell leukemia in transgenic zebrafish. Science 299, 887-890. (Pubitemid 36182446)
-
(2003)
Science
, vol.299
, Issue.5608
, pp. 887-890
-
-
Langenau, D.M.1
Traver, D.2
Ferrando, A.A.3
Kutok, J.L.4
Aster, J.C.5
Kanki, J.P.6
Lin, S.7
Prochownik, E.8
Trede, N.S.9
Zon, L.I.10
Look, A.T.11
-
18
-
-
34249905448
-
Effects of RAS on the genesis of embryonal rhabdomyosarcoma
-
DOI 10.1101/gad.1545007
-
Langenau, D. M., Keefe, M. D., Storer, N. Y., Guyon, J. R., Kutok, J. L., Le, X., Goessling, W., Neuberg, D. S., Kunkel, L. M. and Zon, L. I. (2007). Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 21, 1382-1395. (Pubitemid 46871041)
-
(2007)
Genes and Development
, vol.21
, Issue.11
, pp. 1382-1395
-
-
Langenau, D.M.1
Keefe, M.D.2
Storer, N.Y.3
Guyon, J.R.4
Kutok, J.L.5
Le, X.6
Goessling, W.7
Neuberg, D.S.8
Kunkel, L.M.9
Zon, L.I.10
-
19
-
-
79751468871
-
Zebrafish models for cancer
-
Liu, S. and Leach, S. D. (2011). Zebrafish models for cancer. Annu. Rev. Pathol. 6, 71-93.
-
(2011)
Annu. Rev. Pathol.
, vol.6
, pp. 71-93
-
-
Liu, S.1
Leach, S.D.2
-
20
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
Llovet, J. M. and Bruix, J. (2008). Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48, 1312-1327.
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
21
-
-
33847386180
-
Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine
-
DOI 10.1016/j.ydbio.2006.11.030, PII S0012160606013856
-
Makky, K., Tekiela, J. and Mayer, A. N. (2007). Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine. Dev. Biol. 303, 501-513. (Pubitemid 46341281)
-
(2007)
Developmental Biology
, vol.303
, Issue.2
, pp. 501-513
-
-
Makky, K.1
Tekiela, J.2
Mayer, A.N.3
-
22
-
-
69949129964
-
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
-
Newell, P., Toffanin, S., Villanueva, A., Chiang, D. Y., Minguez, B., Cabellos, L., Savic, R., Hoshida, Y., Lim, K. H., Melgar-Lesmes, P. et al. (2009). Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J. Hepatol. 51, 725-733.
-
(2009)
J. Hepatol.
, vol.51
, pp. 725-733
-
-
Newell, P.1
Toffanin, S.2
Villanueva, A.3
Chiang, D.Y.4
Minguez, B.5
Cabellos, L.6
Savic, R.7
Hoshida, Y.8
Lim, K.H.9
Melgar-Lesmes, P.10
-
23
-
-
81455136715
-
A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish
-
Epub ahead of print
-
Nguyen, A. T., Emelyanov, A., Koh, C. H. V., Spitsbergen, J. M., Lam, S. H., Mathavan, S., Parinov, S. and Gong, Z. (2011). A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish. Dis. Model. Mech. 4 (Epub ahead of print).
-
(2011)
Dis. Model. Mech.
, vol.4
-
-
Nguyen, A.T.1
Emelyanov, A.2
Koh, C.H.V.3
Spitsbergen, J.M.4
Lam, S.H.5
Mathavan, S.6
Parinov, S.7
Gong, Z.8
-
24
-
-
44649114063
-
Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas
-
DOI 10.1053/j.gastro.2008.02.084, PII S0016508508004198
-
Park, S. W., Davison, J. M., Rhee, J., Hruban, R. H., Maitra, A. and Leach, S. D. (2008). Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 134, 2080-2090. (Pubitemid 351783259)
-
(2008)
Gastroenterology
, vol.134
, Issue.7
, pp. 2080-2090
-
-
Park, S.W.1
Davison, J.M.2
Rhee, J.3
Hruban, R.H.4
Maitra, A.5
Leach, S.D.6
-
25
-
-
13444258032
-
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
-
DOI 10.1016/j.cub.2005.01.031
-
Patton, E. E., Widlund, H. R., Kutok, J. L., Kopani, K. R., Amatruda, J. F., Murphey, R. D., Berghmans, S., Mayhall, E. A., Traver, D., Fletcher, C. D. et al. (2005). BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr. Biol. 15, 249-254. (Pubitemid 40205706)
-
(2005)
Current Biology
, vol.15
, Issue.3
, pp. 249-254
-
-
Patton, E.E.1
Widlund, H.R.2
Kutok, J.L.3
Kopani, K.R.4
Amatruda, J.F.5
Murphey, R.D.6
Berghmans, S.7
Mayhall, E.A.8
Traver, D.9
Fletcher, C.D.M.10
Aster, J.C.11
Granter, S.R.12
Look, A.T.13
Lee, C.14
Fisher, D.E.15
Zon, L.I.16
-
26
-
-
77953694704
-
Histopathological classification of hepatocellular carcinoma
-
Roncalli, M., Park, Y. N. and DiTommaso, L. (2010). Histopathological classification of hepatocellular carcinoma. Dig. Liver Dis. 42, S228-S234.
-
(2010)
Dig. Liver Dis.
, vol.42
-
-
Roncalli, M.1
Park, Y.N.2
DiTommaso, L.3
-
27
-
-
34247897276
-
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
-
DOI 10.1038/ncb1567, PII NCB1567
-
Sarkisian, C. J., Keister, B. A., Stairs, D. B., Boxer, R. B., Moody, S. E. and Chodosh, L. A. (2007). Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat. Cell Biol. 9, 493-505. (Pubitemid 46696530)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.5
, pp. 493-505
-
-
Sarkisian, C.J.1
Keister, B.A.2
Stairs, D.B.3
Boxer, R.B.4
Moody, S.E.5
Chodosh, L.A.6
-
28
-
-
0031561127
-
Increased MAPK expression and activity in primary human hepatocellular carcinoma
-
DOI 10.1006/bbrc.1997.6840
-
Schmidt, C. M., McKillop, I. H., Cahill, P. A. and Sitzmann, J. V. (1997). Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 236, 54-58. (Pubitemid 27341838)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.236
, Issue.1
, pp. 54-58
-
-
Schmidt, C.M.1
McKillop, I.H.2
Cahill, P.A.3
Sitzmann, J.V.4
-
29
-
-
65649108558
-
A gene expression signature associated with "K-Ras addiction"reveals regulators of EMT and tumor cell survival
-
Singh, A., Greninger, P., Rhodes, D., Koopman, L., Violette, S., Bardeesy, N. and Settleman, J. (2009). A gene expression signature associated with "K-Ras addiction"reveals regulators of EMT and tumor cell survival. Cancer Cell 15, 489-500.
-
(2009)
Cancer Cell
, vol.15
, pp. 489-500
-
-
Singh, A.1
Greninger, P.2
Rhodes, D.3
Koopman, L.4
Violette, S.5
Bardeesy, N.6
Settleman, J.7
-
30
-
-
79955433548
-
Targeted therapies for hepatocellular carcinoma
-
Villanueva, A. and Llovet, J. M. (2011). Targeted therapies for hepatocellular carcinoma. Gastroenterology 140, 1410-1426.
-
(2011)
Gastroenterology
, vol.140
, pp. 1410-1426
-
-
Villanueva, A.1
Llovet, J.M.2
-
31
-
-
66249116702
-
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
-
Wee, S., Jagani, Z., Xiang, K. X., Loo, A., Dorsch, M., Yao, Y. M., Sellers, W. R., Lengauer, C. and Stegmeier, F. (2009). PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res. 69, 4286-4293.
-
(2009)
Cancer Res.
, vol.69
, pp. 4286-4293
-
-
Wee, S.1
Jagani, Z.2
Xiang, K.X.3
Loo, A.4
Dorsch, M.5
Yao, Y.M.6
Sellers, W.R.7
Lengauer, C.8
Stegmeier, F.9
-
32
-
-
0037025173
-
Addiction to oncogenes-the Achilles heal of cancer
-
Weinstein, I. B. (2002). Addiction to oncogenes-the Achilles heal of cancer. Science 297, 63-64.
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
34
-
-
10644293799
-
Hepatoblastoma in an adult. A case report and clinical review of literatures
-
DOI 10.1016/j.hepres.2004.08.001, PII S1386634604002128
-
Yamazaki, M., Ryu, M., Okazumi, S., Kondo, F., Cho, A., Okada, T., Takayama, W., Kawashima, T., Furuki, A. and Hirata, T. (2004). Hepatoblastoma in an adult A case report and clinical review of literatures. Hepatol. Res. 30, 182-188. (Pubitemid 39654750)
-
(2004)
Hepatology Research
, vol.30
, Issue.3
, pp. 182-188
-
-
Yamazaki, M.1
Ryu, M.2
Okazumi, S.3
Kondo, F.4
Cho, A.5
Okada, T.6
Takayama, W.7
Kawashima, T.8
Furuki, A.9
Hirata, T.10
-
35
-
-
42349111238
-
Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation
-
DOI 10.1002/pbc.21509
-
Yoshida, R., Ogata, T., Masawa, N. and Nagai, T. (2008). Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation. Pediatr. Blood Cancer 50, 1274-1276. (Pubitemid 351555559)
-
(2008)
Pediatric Blood and Cancer
, vol.50
, Issue.6
, pp. 1274-1276
-
-
Yoshida, R.1
Ogata, T.2
Masawa, N.3
Nagai, T.4
-
36
-
-
33745253109
-
Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach
-
DOI 10.1016/j.cell.2006.05.030, PII S0092867406007203
-
Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M., Hannon, G. J. et al. (2006). Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253-1267. (Pubitemid 43929093)
-
(2006)
Cell
, vol.125
, Issue.7
, pp. 1253-1267
-
-
Zender, L.1
Spector, M.S.2
Xue, W.3
Flemming, P.4
Cordon-Cardo, C.5
Silke, J.6
Fan, S.-T.7
Luk, J.M.8
Wigler, M.9
Hannon, G.J.10
Mu, D.11
Lucito, R.12
Powers, S.13
Lowe, S.W.14
-
37
-
-
12144273121
-
In vivo drug discovery in the zebrafish
-
DOI 10.1038/nrd1606
-
Zon, L. I. and Peterson, R. T. (2005). In vivo drug discovery in the zebrafish. Nat. Rev. Drug Discov. 4, 35-44. (Pubitemid 40109588)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.1
, pp. 35-44
-
-
Zon, L.I.1
Peterson, R.T.2
|