Toll-like receptor-7 agonist decoration enhances the adjuvanticity of chitosan-DNA nanoparticles

Journal of Pharmaceutical Sciences

Volumn 101, Issue 3, 2012, Pages 1166-1177

  Heuking, Simon ^a,b   Borchard, Gerrit ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Parc d'Affaires International   (France)

Author keywords

Chitosan; Genetic vaccination; IL 8 release; Mucosalt vaccination; Nanoparticles; Nonviral gene delivery; THP 1 macrophages; Toll like receptor agonist; Vaccine adjuvants

Indexed keywords

6 O CARBOXYMETHYL N,N,N TRIMETHYLCHITOSAN POLYETHYLENE GLYCOL 9 BENZYL 8 HYDROXYADENINE; ADENINE DERIVATIVE; CHITOSAN DERIVATIVE; DNA VACCINE; GREEN FLUORESCENT PROTEIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 8; MACROGOL; NANOPARTICLE; PLASMID DNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; WATER;

ARTICLE; CELLULAR IMMUNITY; COACERVATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ELECTROPHORETIC MOBILITY; ENCAPSULATION; ENZYMATIC DEGRADATION; GEL PERMEATION CHROMATOGRAPHY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFRARED SPECTROSCOPY; LIGHT SCATTERING; LUNG ALVEOLUS CELL; MACROPHAGE; MASS SPECTROMETRY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE CHARGE; ULTRAVIOLET SPECTROSCOPY; ZETA POTENTIAL;

EID: 84855878876     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23017     Document Type: Article

References (37)

1. Chadwick S, Kriegel C, Amiji M. 2009. Delivery strategies to enhance mucosal vaccination. Expert Opin Biol Ther 9:427-440.
2. Borges O, Lebre F, Bento D, Borchard G, Junginger HE. 2010. Mucosal vaccines: Recent progress in understanding the natural barriers. Pharm Res 27:211-223.
3. Chadwick S, Kriegel C, Amiji M. 2010. Nanotechnology solutions for mucosal immunization. Adv Drug Deliv Rev 62:394-407.
4. Borchard G. 2001. Chitosans for gene delivery. Adv Drug Deliv Rev 52:145-150.
5. Esmaeili F, Heuking S, Junginger HE, Borchard G. 2010. Progress in chitosan-based vaccine delivery systems. STP Pharma 20:53-61.
6. Mishra N, Goyal AK, Tiwari S, Paliwal R, Paliwal SR, Vaidya B, Mangal S, Gupta M, Dube D, Mehta A, Vyas SP. 2010. Recent advances in mucosal delivery of vaccines: Role of mucoadhesive/biodegradable polymeric carriers. Expert Opin Ther Pat 20:661-679.
7. Heuking S, Iannitelli A, Di Stefano A, Borchard G. 2009. Toll-like receptor-2 agonist functionalized biopolymer for mucosal vaccination. Int J Pharm 381:97-105.
8. Heuking S, Adam-Malpel S, Sublet E, Iannitelli A, Stefano A, Borchard G. 2009. Stimulation of human macrophages (THP-1) using Toll-like receptor-2 (TLR-2) agonist decorated nanocarriers. J Drug Target 17:662-670.
9. Chuang TH, Ulevitch RJ. 2000. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 11:372-378.
10. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3:196-200.
11. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. 2003. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526-1529.
12. Hirota K, Kazaoka K, Niimoto I, Kumihara H, Sajiki H, Isobe Y, Takaku H, Tobe M, Ogita H, Ogino T, Ichii S, Kurimoto A, Kawakami H. 2002. Discovery of 8-hydroxyadenines as a novel type of interferon inducer. J Med Chem 45:5419-5422.
13. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, Chan M, Tawatao R, Chung M, Shen C, Cottam HB, Lai MM, Raz E, Carson DA. 2006. Activation of anti-hepatitis C virus responses via toll-like receptor 7. Proc Natl Acad Sci U S A 103:1828-1833.
14. Isobe Y, Kurimoto A, Tobe M, Hashimoto K, Nakamura T, Norimura K, Ogita H, Takaku H. 2006. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem 49:2088-2095.
15. Shendage DM, Fröhlich R, Haufe G. 2004. Highly efficient stereoconservative amidation and deamidation of alpha-amino acids. Org Lett 6:3675-3678.
16. *0201-restricted T-cell epitopes of Mycobacterium tuberculosis. Vaccine 22:1609-1615.
17. Köping-Höggård M, Mel'nikova YS, Vårum KM, Lindman B, Artursson P. 2003. Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo. J Gene Med 5:130-141.
18. Köping-Höggård M, Vårum KM, Issa M, Danielsen S, Christensen BE, Stokke BT, Artursson P. 2004. Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther 11:1441-1452.
19. Csaba N, Köping-Höggård M, Alonso MJ. 2009. Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery. Int J Pharm 382:205-214.
20. Sadik CD, Hunfeld KP, Bachmann M, Kraiczy P, Eberhardt W, Brade V, Pfeilschifter J, Mühl H. 2008. Systematic analysis highlights the key role of TLR2/NF-κB/MAP kinase signalling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates. Int J Biochem Cell Biol 40:2508-2521.
21. O'Hagan DT, Singh M, Ulmer JB. 2006. Microparticle-based technology for vaccines. Methods 40:10-19.
22. Schlosser E, Mueller M, Fischer S, Basta S, Busch DH, Gander B, Groettrup M. 2008. TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses. Vaccine 26:1626-1637.
23. Dharmapuri S, Aurisicchio L, Neuner P, Verdirame M, Ciliberto G, La Monica N. 2009. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther 16:462-472.
24. Chan P, Kurisawa M, Chung JE, Yang YY. 2007. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials 28:540-549.
25. Mansouri S, Cuie Y, Winnik F, Shi Q, Lavigne P, Benderdour M, Beaumont E, Fernandes JC. 2006. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials 27:2060-2065.
26. Mao S, Shuai X, Unger F, Wittmar M, Xie X, Kissel T. 2005. Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers. Biomaterials 26:6343-6356.
27. Jeong YI, Kim DG, Jang MK, Nah JW. 2008. Preparation and spectroscopic characterization of methoxy poly(ethylene glycol)-grafted water-soluble chitosan. Carbohydr Res 343:282-289.
28. Prabaharan M, Reis RL, Mano JF. 2007. Carboxymethyl chitosan-graft-phosphatidyl-ethanolamine: Amphiphilic matrices for controlled drug delivery. React Funct Polym 67:43-52.
29. Prabaharan M, Gong S. 2008. Novel thiolated carboxymethyl chitosan-g-β-cyclodextrin as mucoadhesive hydrophobic drug delivery carriers. Carbohydr Polym 73, 117-125.
30. Lee PW, Peng SF, Su CJ, Mi FL, Chen HL, Wei MC, Lin HJ, Sung HW. 2008. The use of biodegradable polymeric nanoparticles in combination with a low-pressure gene gun for transdermal DNA delivery. Biomaterials 29:742-751.
31. Erbacher P, Zou S, Bettinger T, Steffan AM, Remy JS. 1998. Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability. Pharm Res 15:1332-1339.
32. Strand SP, Lelu S, Reitan NK, de Lange Davies C, Artursson P, Vårum KM. 2010. Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking. Biomaterials 31:975-987.
33. Schnoor M, Buers I, Sietmann A, Brodde MF, Hofnagel O, Robenek H, Lorkowski S. 2009. Efficient non-viral transfection of THP-1 cells. J Immunol Methods 344:109-215.
34. Gantier MP, Tong S, Behlke MA, Xu D, Phipps S, Foster PS, Williams BR. 2008. TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J Immunol 180:2117-2124.
35. Yi JY, Jung YJ, Choi SS, Hwang J, Chung E. 2009. Autophagy-mediated anti-tumoral activity of imiquimod in Caco-2 cells. Biochem Biophys Res Commun 386:455-458.
36. Sin J, Kim JJ, Pachuk C, Satishchandran C, Weiner DB. 2000. DNA vaccines encoding interleukin-8 and RANTES enhance antigen-specific Th1-type CD4(+) T-cell-mediated protective immunity against herpes simplex virus type 2 in vivo. J Virol 74:11173-11180.
37. Weterings JJ, Khan S, van der Heden van Noort GJ, Melief CJ, Overkleeft HS, van der Burg SH, Ossendorp F, van der Marel GA, Filippov DV. 2009. 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation. Bioorg Med Chem Lett 19:2249-2251.