3-Alkyl- and 3-amido-isothiazoloquinolin-4-ones as ligands for the benzodiazepine site of GABA A receptors

Bioorganic Chemistry

Volumn 40, Issue 1, 2012, Pages 125-130

  Nilsson, Jakob ^a   Østergaard Nielsen, Elsebet ^b   Liljefors, Tommy ^c   Nielsen, Mogens ^c   Sterner, Olov ^a  

^a LUND UNIVERSITY   (Sweden)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

3 Alkyl 6 methylisothiazolo 5,4 b quinolin 4(9H) ones; 3 Amido 6 methylisothiazolo 5,4 b quinolin 4(9H) ones; Benzodiazepine binding site; GABA A receptors; Pharmacophore model

Indexed keywords

1 (4 HYDROXY 6 METHYL 2 THIOX 1,2 DIHYDROQUINOLIN 3 YL)HEXAN 1 ONE; 1 (4 HYDROXY 6 METHYL 2 THIOXO 1,2 DIHYDROQUINOLIN 3 YL)PENTAN 1 ONE; 1 (4 HYDROXY 6 METHYL 2 THIOXO 1,2 DIHYDROQUINOLIN 3 YL)PROPAN 1 ONE; 3 BUTYL 6 METHYLISOTHIAZOLO[5,4 B]QUINOLIN 4(9H) ONE; 3 ETHYL 6 METHYLISOTHIAZOLO[5,4 B]QUINOLIN 4(9H) ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 HYDROXY 6 METHYL 2 THIOXO 1,2 DIHYDROQUINOLINE 3 CARBONITRILE; 6 METHYL 3 PENTYLISOTHIAZOLO[5,4 B]QUINOLIN 4(9H) ONE; AMIDE; BENZODIAZEPINE DERIVATIVE; FLAVONE DERIVATIVE; LIGAND; METHYL [2 (CYANOACETYL) 4 METHYLPHENYL]DITHIOCARBAMATE; N (6 METHYL 4 OXO 4,9 DIHYDROISOTHIAZOLO[5,4 B]QUINOLIN 3 YL)BUTANAMIDE; N (6 METHYL 4 OXO 4,9 DIHYDROISOTHIAZOLO[5,4 B]QUINOLIN 3 YL)PROPANAMIDE; OXYGEN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL INTERACTION; HYDROGEN BOND; LIPOPHILICITY; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELL MEMBRANE; HYDROGEN BONDING; LIGANDS; QUINOLIZIDINES; RATS; RECEPTORS, GABA-A;

EID: 84855878223     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2011.10.001     Document Type: Article

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