Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABAA receptors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6936-6948

  Lager, Erik ^a   Nilsson, Jakob ^a   Østergaard Nielsen, Elsebet ^b   Nielsen, Mogens ^c   Liljefors, Tommy ^c   Sterner, Olov ^a  

^a LUND UNIVERSITY   (Sweden)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

3 Acyl 1,4 dihydro 4 oxoquinolines; Benzodiazepine binding site; GABAA receptor; GABAA receptor subtypes; Pharmacophore model

Indexed keywords

3 (4,4 DIMETHYLPENTANOYL) 6 ETHYL 4 QUINOLONE; 3 (CYCLOHEXYLACETYL) 6 ETHYL 4 QUINOLONE; 3 (CYCLOPENTYLACETYL) 6 (PYRIDIN 3 YL METHYL) 4 QUINOLONE; 3 (CYCLOPENTYLACETYL) 6 ETHYL 4 QUINOLONE; 3 PENTANOYL 4 QUINOLONE; 3 PENTANOYL 5,6,7,8 TETRAHYDRO 4 QUINOLONE; 3 PENTANOYL 6 (2 PHENYLETHYL) 4 QUINOLONE; 3 PENTANOYL 6 (3 PHENYLPROPYL) 4 QUINOLONE; 3 PENTANOYL 6 (PYRIDIN 2 YL METHYL) 4 QUINOLONE; 3 PENTANOYL 6 (PYRIDIN 3 YL METHYL) 4 QUINOLONE; 3 PENTANOYL 6 (PYRIDIN 4 YL METHYL) 4 QUINOLONE; 3 PENTANOYL 6 PHENYL 4 QUINOLONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 QUINOLONE DERIVATIVE; 6 (2 NAPHTHYLMETHYL) 3 PENTANOYL 4 QUINOLONE; 6 BENZYL 3 (CYCLOPENTYLACETYL) 4 QUINOLONE; 6 BENZYL 3 BUTYRYL 4 QUINOLONE; 6 BENZYL 3 PENTANOYL 4 QUINOLONE; 6 BROMO 3 PENTANOYL 4 QUINOLONE; 6 ETHYL 3 (3 METHYLPENTANOYL) 4 QUINOLONE; 6 ETHYL 3 (4 METHYLPENTANOYL) 4 QUINOLONE; 6 ETHYL 3 (PHENYLACETYL) 4 QUINOLONE; 6 ETHYL 3 HEPTANOYL 4 QUINOLONE; 6 ETHYL 3 HEXANOYL 4 QUINOLONE; 6 ETHYL 3 PENTANOYL 4 QUINOLONE; 6 NITRO 3 PENTANOYL 4 QUINOLONE; BENZODIAZEPINE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PHARMACOPHORE; RAT; SUBSTITUTION REACTION;

4-QUINOLONES; ANIMALS; BENZODIAZEPINES; BINDING SITES; LIGANDS; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47349094959     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.049     Document Type: Article

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