4-Quinolone derivatives: High-affinity ligands at the benzodiazepine site of brain GABAA receptors. Synthesis, pharmacology, and pharmacophore modeling

Journal of Medicinal Chemistry

Volumn 49, Issue 8, 2006, Pages 2526-2533

  Lager, Erik ^a   Andersson, Pierre ^a   Nilsson, Jakob ^a   Pettersson, Ingrid ^d   Nielsen, Elsebet Østergaard ^c   Nielsen, Mogens ^b   Sterner, Olov ^a   Liljefors, Tommy ^b  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NEUROSEARCH A S   (Denmark)

^d NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYLAMINOCARBONYL 6 ETHYL 4 QUINOLONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 QUINOLONE DERIVATIVE; 6 BENZYL 3 ETHOXYCARBONYL 4 QUINOLONE; 6 BENZYL 3 PROPOXYCARBONYL 4 QUINOLONE; 6 BENZYL 3 PROPYLAMINOCARBONYL 4 QUINOLONE; 6 ETHYL 3 (3 METHYLBUTOXYCARBONYL) 4 QUINOLONE; 6 ETHYL 3 PROPYLAMINOCARBONYL 4 QUINOLONE; BENZODIAZEPINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL STRAIN HEK293; CONCENTRATION RESPONSE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PHARMACOPHORE; PROCESS OPTIMIZATION; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

4-QUINOLONES; ANIMALS; BENZODIAZEPINES; BINDING SITES; BRAIN; CELL LINE; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646076225     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm058057p     Document Type: Article

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