SAMe and hur in liver physiology: Usefulness of stem cells in hepatic differentiation research

Methods in Molecular Biology

Volumn 826, Issue , 2012, Pages 133-149

  Gomez Santos, Laura ^a   Vazquez Chantada, Mercedes ^a   Mato, Jose Maria ^a   Martinez Chantar, Maria Luz ^a  

^a CIC BIOGUNE   (Spain)

Author keywords

Hepatocyte; Hepatocyte differentiation; Hepatocyte proliferation; HuR; Liver; MAT (methionine adenosyltransferase); S Adenosylmethionine (SAMe); Stem cells

Indexed keywords

HU ANTIGEN; S ADENOSYLMETHIONINE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; LIVER; LIVER CELL; METABOLISM; METHODOLOGY; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HEPATOCYTES; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; LIVER; MICE; MODELS, BIOLOGICAL; S-ADENOSYLMETHIONINE; SIGNAL TRANSDUCTION; STEM CELLS;

MAMMALIA;

EID: 84855873559     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-468-1_12     Document Type: Article

References (87)

1. Cantoni G.L. (1975) Biological methylation: selected aspects. Annu Rev Biochem 44 , 435-51.
2. Finkelstein J.D., Martin J.J. (1984) Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J Biol Chem 259 , 9508-9513. (Pubitemid 14060511)
3. Mato J.M., Alvarez L., Ortiz P. et al. (1997) S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol Ther 73 , 265-280.
4. Mato J.M., Corrales F.J., Lu S.C. et al. (2002) S -adenosylmethionine: a control switch that regulates liver function. FASEB J 16 , 15-26. (Pubitemid 34027946)
5. Mato J.M., Lu S.C. (2007) Role of S -adenosyll- methionine in liver health and injury. Hepatol 45 ,1306-1312. (Pubitemid 46775795)
6. Cai J., Mao Z., Hwang J.J. et al. (1998) Differential expression of methionine adenosyltransferase genes infl uences the rate of growth of human hepatocellular carcinoma cells. Cancer Res 58 , 1444-1450. (Pubitemid 28193606)
7. Mudd S.H., Poole J.R. (1975) Labile methyl balances for normal humans on various dietary regimens. Metabol 24 , 721-735.
8. Best C.H., Hershey J.M., Huntsman M.E. (1932) The effect of lecithin on fat deposition in the liver of the normal rat. J Physiol 75 , 56-66.
9. Shivapurkar N., Poirier L.A. (1983) Tissue levels of S -adenosylmethionine and S -adenosyl homocysteine in rats fed methyl-defi cient, amino acid-defi ned diets for one to fi ve weeks. Carcinogenesis 4 , 1051-157.
10. Duce A.M., Ortiz P., Cabrero C. et al. (1988) S-Adenosyl-L-methionine synthetase and phospholipids methyltransferase are inhibited in human cirrhosis. Hepatol 8 , 65-68. (Pubitemid 18092060)
11. Vendemiale G., Altomare E., Trizio T. et al. (1989) Effect of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Stand J Gastroenterol 24 , 407-415. (Pubitemid 19141425)
12. Mato J.M., Cámara J., Fernández de Paz J. et al. (1999) S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. Hepatol 30 , 1081-1089. (Pubitemid 29278753)
13. Mudd S.H., Brosnan J.T., Brosnan M.E. et al. (2007) Methyl balance and transmethylation fl uxes in humans. Am J Clin Nutr 85 , 19-25. (Pubitemid 46067610)
14. Martínez-Chantar M.L., Vázquez-Chantada M., Ariz U. et al. (2008) Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatol 47 ,1191-1199. (Pubitemid 351547905)
15. Tseng T.L., Shih Y.P., Huang Y.C. et al. (2003) Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. Cancer Res 63 , 647-654.
16. Martinez-Chantar M.L., Corrales F.J., Martinez-Cruz L.A. et al. (2002) Spontaneous oxidative stress and liver tumors inmice lacking methionine adenosyltransferase 1A. FASEB J 16 , 1292-1294.
17. Lu S.C., Alvarez L., Huang Z.Z. et al. (2001) Methionine adenosyltransferase1A knockout mice are predisposed to liver injury and exhibit increasedexpression of genes involved in proliferation. Proc Natl Acad Sci USA 98 , 5560-5565. (Pubitemid 32435681)
18. Chen L., Zeng Y., Yang H. et al. (2004) Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J 18 , 914-916.
19. Varela-Rey M., Fernández-Ramos D., Martínez-López N. et al. (2009) Impaired liver regeneration in mice lacking glycine N-methyltransferase. Hepatol 50 , 443-452.
20. Michalopoulos G.K., DeFrances M.C. (1997) Liver regeneration. Science 276 , 60-66.
21. Higgins G.M., Anderson R.M. (1931) Experimental pathology of the liver. I.Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12 ,186-202.
22. Fausto N., Campbell J.S., Riehle K.J. (2006) Liver regeneration. Hepatol 43 (2 Suppl 1): S45-53.
23. Lindroos P.M., Zarnegar R., Michalopoulos G.K .(1991) Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon etrachloride administration. Hepatol 13 , 743-750.
24. Hortelano S., Dewez B., Genaro A.M. et al. (1995) Nitric oxide is released in regenerating liver after partial hepatectomy. Hepatol 21 , 776-786.
25. Ruiz F., Corrales F.J., Miqueo C. et al. (1998) Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation. Hepatol 28 , 1051-1057. (Pubitemid 28450266)
26. Pérez-Mato I., Castro C., Ruiz F.A. et al. (1999) Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol. J Biol Chem 274 , 17075-17079.
27. Garcia-Trevijano E.R., Martinez-Chantar M.L., Latasa M.U. et al. (2002) NO sensitizes rat hepatocytes to proliferation by modifying -adenosylmethionine levels. Gastroenterol 122 , 1355-1363. (Pubitemid 34465178)
28. Huang Z.Z., Mao Z., Cai J. et al. (1998) Changes in methionine adenosyltransferase during liver regeneration in the rat. Am J Physiol 275 , G14-G21.
29. Pascale R.M., Simile M.M., De Miglio M.R. et al. (1995) Chemoprevention by S-adenosyl- L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Carcinogenesis 16 . 427-430.
30. Ponzetto C., Bardelli A., Zhen Z. et al. (1994) A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 77 , 261-277.
31. Paumelle R., Tulasne D., Kherrouche Z. et al. (2002) Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 21 , 2309-2319. (Pubitemid 34407290)
32. Vázquez-Chantada M., Ariz U., Varela-Rey M. et al. (2009) Evidence for LKB1/AMPactivated protein kinase/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatol 49 , 608-617.
33. Hardie D.G., Hawley S.A., Scott J.W. (2006) AMP-activated protein kinase-development of the energy sensory concept. J Physiol 574 , 7-15. (Pubitemid 43905792)
34. Wang W., Fan J., Yang X. et al. (2002) AMPactivated kinase regulates cytoplasmic HuR. Mol Cell Biol 22 , 3425-3436. (Pubitemid 34453982)
35. Martinez-Chantar M.L., Vazquez-Chantada M., Garnacho M. et al. (2006) S -adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Gastroenterol 131 , 223-232. (Pubitemid 44040917)
36. Bolognani F., Perrone-Bizzozero N.I. (2008) RNA-protein interactions and control of mRNA stability in neurons. J Neurosci Res 86 , 481-489. (Pubitemid 351204460)
37. Garneau N.L., Wilusz J., Wilusz C.J. (2007) The highways and byways of mRNA decay. Nat Rev Mol Cell Biol 8 , 113-126. (Pubitemid 46432531)
38. Wilusz C.J., Wormington M., Peltz S.W. (2001) The cap-to-tail guide to mRNA turnover. Nat Rev Mol Cell Biol 2 , 237-246. (Pubitemid 33676966)
39. Ma W.J., Cheng S., Campbell C. et al. (1996) Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem 271 , 8144-8151. (Pubitemid 26108641)
40. Park S., Myszka D.G., Yu M. et al. (2000) HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. Mol Cell Biol 20 , 4765-4772. (Pubitemid 30396123)
41. Xu N., Chen C.Y., Shyu A.B. (1997) Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay. Mol Cell Biol 17 , 4611-4621. (Pubitemid 27318137)
42. Bevilacqua A., Ceriani M.C., Capaccioli S. et al. (2003) Post-transcriptional regulation of gene expression by degradation of messenger RNAs. J Cell Physiol 195 , 356-372. (Pubitemid 36529864)
43. Keene J.D. (1999) Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc Natl Acad Sci USA 96 , 5-7. (Pubitemid 29036041)
44. Wang W., Furneaux H., Cheng H. et al. (2000) HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol 20 , 760-769. (Pubitemid 30044212)
45. Wang W., Caldwell M.C., Lin S. et al. (2000) HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 19 , 2340-2350. (Pubitemid 30259015)
46. Fan X.C., Steitz J.A. (1998) HNS, a nuclearcytoplasmic shuttling sequence in HuR. Proc Natl Acad Sci USA 95 , 15293-15298. (Pubitemid 29018692)
47. Güttinger S., Mühlhäusser P., Koller-Eichhorn R. et al. (2004)Transportin2 functions as importin and mediates nuclear import of HuR. Proc Natl Acad Sci USA 101 , 2918-2923. (Pubitemid 38327711)
48. Rebane A., Aab A., Steitz J.A. (2004) Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. RNA 10 , 590-599. (Pubitemid 38405937)
49. Abdelmohsen K., Lal A., Kim H.H. et al. (2007) Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle 6 , 1288-1292. (Pubitemid 47327958)
50. Katsanou V., Papadaki O., Milatos S. et al. (2005) HuR as a negative posttranscriptional modulator in infl ammation. Mol Cell 19 , 777-789. (Pubitemid 41316672)
51. Levadoux-Martin M., Gouble A., Jégou B. et al. (2003) Impaired gametogenesis in mice that overexpress the RNA-binding protein HuR. EMBO Rep 4 , 394-399. (Pubitemid 36622005)
52. Van der Giessen K., Gallouzi I. E. (2007) Involvement of transportin 2-mediated HuR import in muscle cell differentiation. Mol Biol Cell 18 , 2619-2629. (Pubitemid 47025726)
53. Figueroa A., Cuadrado A., Fan J. et al. (2003) Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol 23 , 4991-5004. (Pubitemid 36793344)
54. Gantt K., Cherry J., Tenney R. et al. (2005) An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein {beta} (C/EBP{beta}) mRNA by HuR and its translocation to the cytosol. J Biol Chem 280 , 24768-2474.
55. Doller A., Pfeilschifter J., Eberhardt W. (2008) Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. Cell Signal 20 , 2165-2173.
56. Abdelmohsen K., Pullmann R Jr., Lal A. et al. (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 25 , 543-557. (Pubitemid 46274441)
57. Kim H. H., Abdelmohsen K., Lal A. et al. (2008) Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev 22 , 1804-1815. (Pubitemid 351915505)
58. Li H., Park S., Kilburn B. et al. (2002) Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator- associated arginine methyltransferase. J BiolChem 277 , 44623-44630. (Pubitemid 36159051)
59. Vázquez-Chantada M., Fernández-Ramos D. et al. ( 2010) HuR/Methyl-HuR and AU-Rich RNA Binding Factor 1 Regulate the Methionine Adenosyltransferase Expressed During Liver Proliferation, Differentiation, and Carcinogenesis. Gastroenterol 138 , 1943-1953.
60. Cai J., Sun W.M., Hwang J.J. et al. (1996) Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and signifi cance. Hepatol 24 , 1090-1097. (Pubitemid 26365909)
61. García-Trevijano E. R., Latasa M.U., Carretero M. V. et al. (2000) S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver. FASEB J 14 , 2511-2518.
62. Pascale R.M., Marras V., Simile M.M. et al. (1992) Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a longterm study. Cancer Res 52 , 4979-4986.
63. Si-Tayeb K, Lemaigre FP, Duncan SA (2010) Organogenesis and development of the liver. Dev Cell 18 , 175-189.
64. Lemaigre F.P. (2009) Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies. Gastroenterol 137 , 62-79.
65. Yamamoto H., Quinn G., Asari A. et al. (2003) Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatol 37 , 983-993 (Pubitemid 36538675)
66. Cai J., Zhao Y., Liu Y. et al. (2007) Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatol 45 , 1229-1239. (Pubitemid 46775786)
67. Banas A., Teratani T., Yamamoto Y. et al. (2007) Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatol 46 , 219-228. (Pubitemid 47171939)
68. Kang X.Q., Zang W.J., Song T.S. et al. (2005) Rat bone marrow mesenchymal stem cells differentiate into hepatocytes in vitro. World J Gastroenterol 11 , 3479-3484.
69. Snykers S., Vanhaecke T., De Becker A. et al. (2007) Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC Dev Biol 7 , 24.
70. Tanimizu N., Saito H., Mostov K. et al. (2004) Long-term culture of hepatic progenitors derived from mouse Dlk + hepatoblasts. J Cell Sci 117 (Pt 26), 6425-6434. (Pubitemid 40214568)
71. Fujikawa T., Hirose T., Fujii H. et al. (2003) Purifi cation of adult hepatic progenitor cells using green fl uorescent protein (GFP)- transgenic mice and fl uorescence-activated cell sorting. J Hepatol 39 , 162-170. (Pubitemid 36920550)
72. Nowak G., Ericzon B.G., Nava S. et al. (2005) Identifi cation of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo. Gut 54 , 972-979. (Pubitemid 40873912)
73. Si-Tayeb K., Noto F.K., Nagaoka M. et al. (2010) Highly effi cient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatol 51 , 297-305.
74. Gai H, Leung EL, Costantino PD et al (2009) Generation and characterization of functional cardiomyocytes using induced pluripotent stem cells derived from human fi broblasts. Cell Biol Int 33 , 1184-1193.
75. Lysy P.A., Campard D., Smets F. et al. (2008) Stem cells for liver tissue repair: current knowledge and perspectives. World J Gastroenterol 14 , 864-875. (Pubitemid 351325025)
76. Cho C.H., Parashurama N., Park E.Y. et al. (2008) Homogeneous differentiation of hepatocyte- like cells from embryonic stem cells: applications for the treatment of liver failure. FASEB J 22 , 898-909. (Pubitemid 351348141)
77. Martínez-Chantar M.L., Latasa M.U., Varela- Rey M. et al. (2003) L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. JBiol Chem 278 , 19885-19890. (Pubitemid 36799177)
78. Yang H., Sadda M.R., Li M. et al. (2004) S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S). Hepatol 40 , 221-231. (Pubitemid 38868941)
79. Zhuge J (2008) A decrease in S-adenosyl-Lmethionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1. Mol Cell Biochem 314 , 105-112.
80. Heermann K.H., Gültekin H., Gerlich W.H. (1988) Protein blotting: techniques and application in virus hepatitis research. Ric Clin Lab 18 , 193-221.
81. Gassmann M., Grenacher B., Rohde B. et al. (2009) Quantifying Western blots: pitfalls of densitometry. Electrophoresis 30 , 1845-1855.
82. Marx J. (2000) Interfering with gene expression. Science 288 , 1370-1372. (Pubitemid 30366313)
83. Alessi D.R., Cuenda A., Cohen P. et al. (1995) PD 098059 is a specifi c inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270 , 27489-27494.
84. Fehrenbach H., Weiskirchen R., Kasper M. et al. (2001) Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofi broblasts. Hepatol 34 , 943-952. (Pubitemid 33032029)
85. Vlahos C.J., Matter W.F., Hui K.Y. et al. (1994) A specifi c inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002). J Biol Chem 269 , 5241-5248.
86. Duran J., Obach M., Navarro-Sabate A. et al. (2009) Pfkfb3 is transcriptionally upregulated in diabetic mouse liver through proliferative signals. FEBS J 276 , 4555-4568.
87. Tenenbaum S.A., Carson C.C., Lager P.J. et al. (2000) Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. Proc Natl Acad Sci USA 97 , 14085-14090. (Pubitemid 32016534)