A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1

Molecular and Cellular Biochemistry

Volumn 314, Issue 1-2, 2008, Pages 105-112

  Zhuge, Jian ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Arachidonic acid; Chlormethiazole; Cycloleucine; CYP2E1; Pyrazole; Reactive oxygen species

Indexed keywords

ARACHIDONIC ACID; CLOMETHIAZOLE; CYCLOLEUCINE; CYTOCHROME P450 2E1; LIPID; POLYUNSATURATED FATTY ACID; PYRAZOLE; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; SODIUM CHLORIDE; TRIFLUOPERAZINE; TROLOX C;

ALCOHOL LIVER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME INDUCTION; ENZYME INHIBITION; INCUBATION TIME; INHIBITION KINETICS; LIPID PEROXIDATION; LIVER CELL; LIVER PROTECTION; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PATHOPHYSIOLOGY; RAT;

ANIMALS; APOPTOSIS; ARACHIDONIC ACID; CELL SURVIVAL; CYCLOLEUCINE; CYTOCHROME P-450 CYP2E1; CYTOTOXINS; DRUG SYNERGISM; HEPATOCYTES; LIPID PEROXIDATION; LIVER; MALE; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; S-ADENOSYLMETHIONINE;

RATTUS;

EID: 45449105960     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9770-0     Document Type: Article

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