Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: The HyperGEN study

Journal of Human Hypertension

Volumn 26, Issue 2, 2012, Pages 133-140

  Lynch, A I ^a   Tang, W ^b   Shi, G ^c   Devereux, R B ^d   Eckfeldt, J H ^a   Arnett, D K ^e  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

ACE gene; AGT gene; epistasis; left ventricular hypertrophy; left ventricular mass

Indexed keywords

ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AFRICAN AMERICAN; AGED; ALLELE; ARTICLE; ECHOCARDIOGRAPHY; FEMALE; GENE INTERACTION; GENETIC EPISTASIS; GENETIC VARIABILITY; HEART LEFT VENTRICLE HYPERTROPHY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; ANGIOTENSINOGEN; CHI-SQUARE DISTRIBUTION; EPISTASIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HOMOZYGOTE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LINEAR MODELS; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; RISK ASSESSMENT; RISK FACTORS; UNITED STATES; YOUNG ADULT;

EID: 84855851046     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2010.131     Document Type: Article

References (40)

1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561-1566. (Pubitemid 20176696)
2. Savage DD, Levy D, Dannenberg AL, Garrison RJ, Castelli WP. Association of echocardiographic left ventricular mass with body size, blood pressure and physical activity (the Framingham Study). Am J Cardiol 1990; 65: 371-376. (Pubitemid 20038922)
3. Arnett DK, Hong Y, Bella JN, Oberman A, Kitzman DW, Hopkins PN et al. Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: the HyperGEN study. Hypertension Genet-ic Epidemiology Network. Am J Hypertens 2001; 14: 1226-1230. (Pubitemid 33151479)
4. Swan L, Birnie DH, Padmanabhan S, Inglis G, Connell JM, Hillis WS. The genetic determination of left ventricular mass in healthy adults. Eur Heart J 2003; 24: 577-582. (Pubitemid 36343104)
5. Gharavi AG, Lipkowitz MS, Diamond JA, Jhang JS, Phillips RA. Deletion polymorphism of the angioten-sin-converting enzyme gene is independently asso-ciated with left ventricular mass and geometric remodeling in systemic hypertension. Am J Cardiol 1996; 77: 1315-1319. (Pubitemid 26227257)
6. Gomez-Angelats E, de la Sierra A, Enjuto M, Sierra C, Oriola J, Francino A et al. Lack of association between ACE gene polymorphism and left ventricular hyper-trophy in essential hypertension. J Hum Hypertens 2000; 14: 47-49. (Pubitemid 30113631)
7. Karjalainen J, Kujala UM, Stolt A, Mantysaari M, Viitasalo M, Kainulainen K et al. Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes. J Am Coll Cardiol 1999; 34: 494-499.
8. Kauma H, Ikaheimo M, Savolainen MJ, Kiema TR, Rantala AO, Lilja M et al. Variants of renin-angiotensin system genes and echocardiographic left ventricular mass. Eur Heart J1998; 19: 1109-1117. (Pubitemid 28321392)
9. Kuznetsova T, Staessen JA, Thijs L, Kunath C, Olszanecka A, Ryabikov A et al. Left ventricular mass in relation to genetic variation in angiotensin II receptors, renin system genes, and sodium excretion. Circulation 2004; 110: 2644-2650. (Pubitemid 39453014)
10. Lindpaintner K, Lee M, Larson MG, Rao VS, Pfeffer MA, Ordovas JM et al. Absence of association or genetic linkage between the angiotensin-converting- enzyme gene and left ventricular mass. N Engl J Med 1996; 334: 1023-1028. (Pubitemid 26123778)
11. Mayet J, O'Kane KP, Elton R, Johnstone HA, Shahi M, Ozkor MA et al. Left ventricular hypertrophy, blood pressure and ACE genotype in untreated hypertension. J Hum Hypertens 1997; 11: 595-597. (Pubitemid 27478546)
12. Moleda P, Majkowska L, Kaliszczak R, Safranow K, Adler G, Goracy I. Insertion/deletion polymorphism of angiotensin I converting enzyme gene and left ventricular hypertrophy in patients with type 2 diabetes mellitus. Kardiol Pol 2006; 64: 959-965; discussion 966. (Pubitemid 44580869)
13. Perticone F, Ceravolo R, Cosco C, Trapasso M, Zingone A, Malatesta P et al. Deletion polymorphism of angiotensin-converting enzyme gene and left ventri-cular hypertrophy in southern Italian patients. J Am Coll Cardiol 1997; 29: 365-369. (Pubitemid 27059967)
14. Saeed M, Siddiqui S, Khan A, Butt ZA, Parvez SH, Frossard PM. Association of ACE polymorphisms with left ventricular hypertrophy. Neuro Endocrinol Lett 2005; 26: 393-396. (Pubitemid 41518783)
15. Tang W, Devereux RB, Rao DC, Oberman A, Hopkins PN, Kitzman DW et al. Associations between angio-tensinogen gene variants and left ventricular mass and function in the HyperGEN study. Am Heart J 2002; 143: 854-860. (Pubitemid 34595344)
16. West MJ, Summers KM, Wong KK, Burstow DJ. Renin-angiotensin system gene polymorphisms and left ventricular hypertrophy. The case against an associa-tion. Adv Exp Med Biol 1997; 432: 117-122. (Pubitemid 28036003)
17. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346. (Pubitemid 20370444)
18. Gaillard-Sanchez I, Mattei MG, Clauser E, Corvol P. Assignment by in situ hybridization of the angiotensi-nogen gene to chromosome band 1q4, the same region as the human renin gene. Hum Genet 1990; 84: 341-343. (Pubitemid 20076394)
19. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal tran-scription in vitro. J Clin Invest 1997; 99: 1786-1797. (Pubitemid 27164639)
20. Zhao YY, Zhou J, Narayanan CS, Cui Y, Kumar A. Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene. Hypertension 1999; 33: 108-115. (Pubitemid 29061850)
21. Jeunemaitre XSF, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71: 169-180.
22. Kuznetsova T, Staessen JA, Wang JG, Gasowski J, Nikitin Y, Ryabikov A et al. Antihypertensive treat-ment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis. J Hum Hypertens 2000; 14: 447-454. (Pubitemid 30461932)
23. Goracy J, Peregud-Pogorzelska M, Goracy I, Kaczmarc-zyk M, Kornacewicz-Jach Z, Naruszewicz M et al. Allelic variants of genes: angiotensin I-converting enzyme (ACE), angiotensin-II type 1 receptor (AT1R), methylenetetrahydrofolate reductase and left ventri-cular mass in patients with myocardial infarction. Pol Arch Med Wewn 2006; 115: 105-111. (Pubitemid 44047451)
24. Perkins MJ, Van Driest SL, Ellsworth EG, Will ML, Gersh BJ, Ommen SR et al. Gene-specific modifying effects of pro-LVH polymorphisms involving the renin-angiotensin-aldosterone system among 389 unrelated patients with hypertrophic cardiomyopathy. Eur Heart J 2005; 26: 2457-2462. (Pubitemid 41552976)
25. Jeng JR. Left ventricular mass, carotid wall thickness, and angiotensinogen gene polymorphism in patients with hypertension. Am J Hypertens 1999; 12: 443-450.
26. Kuznetsova T, Staessen JA, Reineke T, Olszanecka A, Ryabikov A, Tikhonoff V et al. Context-dependency of the relation between left ventricular mass and AGT gene variants. J Hum Hypertens 2005; 19: 155-163. (Pubitemid 40220639)
27. Ott CST, Hilgers KF, Kreutz R, Schlaich MP, Schmieder RE. Left-ventricular structure and function are influ-enced by angiotensinogen gene polymorphism (-20 A/ C) in young male patients. Am J Hypertens 2007; 20: 974-980. (Pubitemid 47313616)
28. Patel DA, Li S, Chen W, Srinivasan SR, Boerwinkle E, Berenson GS, Bogalusa Heart Study. G-6A polymorphism of the angiotensinogen gene and its association with left ventricular mass in asymptomatic young adults from a biethnic community: the Bogalusa Heart Study. Am J Hypertens 2005; 18: 1137-1141.
29. Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J et al. Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. Hum Mol Genet 2006; 15: 1365-1374.
30. Cicila GT, Morgan EE, Lee SJ, Farms P, Yerga-Woolwine S, Toland EJ et al. Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model. Hypertension 2009; 53: 725-732.
31. Kardia SL, Bielak LF, Lange LA, Cheverud JM, Boerwinkle E, Turner ST et al. Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification. Med Sci Monit 2006; 12: CR150-CR158.
32. Palijan A, Dutil J, Deng AY Quantitative trait loci with opposing blood pressure effects demonstrating epista-sis on Dahl rat chromosome 3. Physiol Genomics 2003; 15: 1-8.
33. Williams RR, Rao DC, Ellison RC, Arnett DK, Heiss G, Oberman A et al. NHLBI family blood pressure program: methodology and recruitment in the Hyper-GEN network. Hypertension genetic epidemiology network Ann Epidemiol 2000; 10: 389-400. (Pubitemid 30645793)
34. Devereux RB, Lutas EM, Casale PN, Kligfield P, Eisenberg RR, Hammond IW et al. Standardization of M-mode echocardiographic left ventricular anatomic measurements. J Am Coll Cardiol 1984; 4: 1222-1230. (Pubitemid 15184198)
35. de Simone G, Devereux RB, Daniels SR, Koren MJ, Meyer RA, Laragh JH. Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 1995; 25: 1056-1062.
36. Kim DS, Choi SI, Lee HS, Park JK, Yi HK. Determina-tion of human angiotensin converting enzyme (ACE) gene polymorphisms in erectile dysfunction: fre-quency differences of ACE gene polymorphisms according to the method of analysis. Clin Chem Lab Med 2001; 39: 11-14. (Pubitemid 32186272)
37. 235 → Thr allele of the human angiotensinogen gene. Hum Mol Genet 1993; 2: 609-610. (Pubitemid 23140035)
38. Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M et al. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet 1997; 60: 1448-1460. (Pubitemid 27258077)
39. Ishigami T, Umemura S, Tamura K, Hibi K, Nyui N, Kihara M et al. Essential hypertension and 5? upstream core promoter region of human angiotensinogen gene. Hypertension 1997; 30: 1325-1330. (Pubitemid 27528070)
40. Nakajima T, Wooding S, Sakagami T, Emi M, Tokunaga K, Tamiya G et al. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world. Am J Hum Genet 2004; 74: 898-916. (Pubitemid 38568964)