The genetic determination of left ventricular mass in healthy adults

European Heart Journal

Volumn 24, Issue 6, 2003, Pages 577-582

  Swan, L ^a,b   Birnie, D H ^a   Padmanabhan, S ^a   Inglis, G ^a   Connell, J M C ^a   Hillis, W S ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Genetics; Hypertrophy; Ventricle

Indexed keywords

ALDOSTERONE SYNTHASE; BETA 1 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CORRELATION COEFFICIENT; DIZYGOTIC TWINS; ECHOCARDIOGRAPHY; FEMALE; GENETICS; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; POPULATION RESEARCH; PRIORITY JOURNAL; TWINS;

COHORT STUDIES; ECHOCARDIOGRAPHY; FEMALE; GENOTYPE; HEART; HEART VENTRICLES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 0037345180     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0195-668X(02)00524-9     Document Type: Article

References (27)

1. Casale P.N., Devereux R.B., Milner M. et al. Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann Intern Med 1986;105:173-8.
2. Levy D., Garrison R.J., Savage D.D., Kannel W.B., Castelli W.P. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990;322:1561-6.
3. Roman M.J., Pickering T.G., Schwartz J.E., Pini R., Devereux R.B. Association of carotid atherosclerosis and left ventricular hypertrophy. J Am Coll Cardiol 1995;25:83-90.
4. Arnett D.K., Rautaharju P., Crow R. et al. Black-white differences in electrocardiographic left ventricular mass and its association with blood pressure (the ARIC study). Atherosclerosis Risk in Communities. Am J Cardiol 1994; 74:247-52.
5. Bonne G., Carrier L., Richard P., Hainque B., Schwartz K. Familial hypertrophic cardiomyopathy: From mutations to functional defects. Circ Res 1998;83:580-93.
6. Klissouras K. Heritability of adaptive variation. J Appl Physiol 1971;31:338-44.
7. Landry F., Bouchard C., Dumesnil J. Cardiac dimension changes with endurance training. Indications of a genotype dependency. JAMA 1985;254:77-80.
8. Adams T.D., Yanowitz F.G., Fisher A.G. et al. Heritability of cardiac size: an echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. Circulation 1985; 71:39-44.
9. Harshfield G.A., Grim C.E., Hwang C. et al. Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins. Am J Hypertens 1990;3:538-43.
10. Fagard R., Brguljan J., Staessen J. et al. Heritability of conventional and ambulatory blood pressures. A study in twins. Hypertension 1995;26:919-24.
11. Verhaaren H.A., Schieken R.M., Mosteller M. et al. Bivariate genetic analysis of left ventricular mass and weight in pubertal twins (the Medical College of Virginia twin study). Am J Cardiol 1991;68:661-8.
12. Devereux R.B., Alonso D.R., Lutas E.M. et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986;57:450-8.
13. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning, a laboratory manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
14. Siffert W., Rosskopf D., Siffert G. et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998;18.
15. Kupari M., Hautanen A., Lankinen L. et al. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Circulation 1998;97:569-75.
16. Mason D.A., Moore J.D., Green S.A. et al. A gain-of-function polymorphism in a G-protein coupling domain of the human betal-adrenergic receptor. J Biol Chem 1999;274:12670-4.
17. Falconer D.S., MacKay T.F.C. Introduction to quantitative genetics. 4th edn Addison-Wesley: New York, 1998.
18. Tambs K., Eaves L.J., Mourn T. et al. Age-specific genetic effects for blood pressure. Hypertension 1993;22:789-95.
19. Bielen E., Fagard R., Amery A. Inheritance of heart structure and physical exercise capacity: a study of left ventricular structure and exercise capacity in 7-year-old twins. Eur Heart J 1990;11:7-16.
20. Post W.S., Larson M.G., Myers R.H. et al. Heritability of left ventricular mass: the Framingham Heart Study. Hypertension 1997;30:1025-8.
21. Siffert W., Rosskopf D., Siffert G. et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998;18:45-8.
22. Jacobi J., Hilgers K.F., Schlaich M.P. et al. 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. J Hypertens 1999;17:1457-62.
23. Poch E., Gonzalez D., Gomez-Angelats E. et al. G-Protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertension. Hypertension 2000;35:214-8.
24. Schunkert H., Hengstenberg C., Holmer S.R. et al. Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation 1999;99:2255-60.
25. Schunkert H., Hense H.W., Holmer S.R. et al. Association between a deletion polymorphism of the angiotensin- converting-enzyme gene and left ventricular hypertrophy. N Engl J Med 1994;330:1634-8.
26. Lindpaintner K., Lee M., Larson M.G. et al. Absence of association or genetic linkage between the angiotensin- converting-enzyme gene and left ventricular mass. N Engl J Med 1996;334:1023-8.
27. Jones A., Montgomery H. The Gly389Arg beta-1 adrenoceptor polymorphism and cardiovascular disease: time for a rethink in the funding of genetic studies? Eur Heart J 2002; 23:1071-4.