Heavy chain V region diversity in the duck-billed platypus (Ornithorhynchus anatinus): Long and highly variable complementarity-determining region 3 compensates for limited germline diversity

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 5155-5162

  Johansson, Jeannette ^a   Aveskogh, Maria ^a   Munday, Barry ^a   Hellman, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN;

ANTIGEN ANTIBODY REACTION; ARTICLE; BIODIVERSITY; CAMEL; COMPLEMENTARITY DETERMINING REGION; COW; DNA SEQUENCE; EVOLUTION; GERM LINE; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MAMMAL; MONOTREMATE; MOUSE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLATYPUS; PRIORITY JOURNAL; SHARK; SHEEP; UNINDEXED SEQUENCE;

EID: 0037093863     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.5155     Document Type: Article

References (51)

1. H locus
2. H gene families reveals a common organization for three Igh haplotypes
3. The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes
4. Mouse variable-region gene families: Complexity, polymorphism and use in non-autoimmune responses
5. H gene family
6. A molecular timescale for vertebrate evolution
7. Ig heavy chain of the sturgeon Acipenser baeri: cDNA sequence and diversity
8. H gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus
9. H gene of the chicken with a high incidence in the D region
10. H chromosomal region
11. HIII
12. Conservation of an immunoglobutin variable-region gene family indicates a specific, noncoding function
13. H families
14. Heavy chain variable region gene families evolved early in phylogeny: Ig complexity in fish
15. Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding
16. Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM Abs
17. H gene family dominates the bovine immunoglobulin repertoire
18. Gene conversion contributes to Ig light chain diversity in cattle
19. H family
20. H repertoire of a marsupial (Monodelphis domestica)
21. Evidence for an early appearance of modem post-switch isotypes in mammalian evolution: Cloning of IgE, IgG and IgA from the marsupial Monodelphis domestica
22. Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica
23. Marsupial light chains: Complexity and conservation of λ in the opossum Monodelphis domestica
24. Marsupial light chains: IGK with four V families in the opossum Monodelphis domestica
25. Histological and immunohistological investigation of lymphoid tissue in the platypus (Ornithorhynchus anatinus)
26. Major immunoglobulin classes of the echidna (Tachyglossus aculeatus)
27. Immunoglobulin γ chains of a monotreme mammal, the echidna (Tachyglossus aculeatus): Amino acid composition and partial amino acid sequence
28. Studies on marsupial proteins. IV. Amino acid sequence of myoglobin from the red kangaroo, Megaleia rufa
29. The complete mitochondrial genome of the wallroo (Macropus robustus) and the phylogenetic relationship among Monotremata, Marsupialia, and Eutheria
30. The mitochondrial genome of a monotreme: The platypus (Ornithorhynchus anatinus)
31. Evolution of the monotremes: The sequences of the protamine PI genes of platypus and echidna
32. Molecular phylogeny and evolution of the neurotrophins from monotremes and marsupials
33. Monotreme IGF2 expression and ancestral origin of genomic imprinting
34. First Mesozoic mammal from Australia: An early Cretaceous monotreme
35. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
36. DNA sequencing with chain-terminating inhibitors
37. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
38. A Shannon entropy analysis of immunoglobulin and T cell receptor
39. Variability of the immunoglobulin light chain in the Siberian sturgeon, Acipenser baeri
40. Variable region diversity of the Atlantic cod (Gadus morhua L.) immunoglobulin heavy chain
41. Cloning, structural analysis, and expression of the pig 1gE ε chain
42. Immunoglobulin gene organization and the mechanism of repertoire development
43. Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins
44. H domain from naturally occurring camel heavy chain immunoglobulins lacking light chains
45. H sequences from conventional and heavy chain Abs
46. HH and specific mechanisms enlarge the antigen-binding repertoire
47. H gene family
48. H family and long CDR3s in the variable region of cattle Ig heavy chains
49. Naturally occurring Abs devoid of light chains
50. Recognition of antigens by single-domain Ab fragments: The superfluous luxury of paired domains