Synthesis, biological evaluation, and docking studies of tetrahydrofuran-cyclopentanone-and cyclopentanol-based ligands acting at adrenergic α 1- and serotonine 5-HT 1A receptors

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 23-36

  Prandi, Adolfo ^a   Franchini, Silvia ^a   Manasieva, Leda Ivanova ^a   Fossa, Paola ^b   Cichero, Elena ^b   Marucci, Gabriella ^c   Buccioni, Michela ^c   Cilia, Antonio ^d   Pirona, Lorenza ^d   Brasili, Livio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

^d Recordati SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

(5,5 DIPHENYLOXOLAN 2 YL)METHANOL; (5,5 DIPHENYLOXOLAN 2 YL)METHYL 4 METHYLBENZENE 1 SULFONATE; 1 [(5,5 DIPHENYLOXOLAN 2 YL)METHYL] 4 (2 METHOXYPHENYL)PIPERAZINE; 2 AMINE 3,3 DIPHENYL CYCLOPENT 1 ENECARBONITRILE; 2,2 DIPHENYL CYCLOPENTANONE; 2,2 DIPHENYLHEXANEDINITRILE; 5 (CHLOROMETHYL) 2,2 DIPHENYLOXOLANE; 5 [[(2 PHENOXYETHYL)AMINO]METHYL] 2,2 DIPHENYLCYCLOPENTAN 1 OL; 5 [[(2 PHENOXYETHYL)AMINO]METHYL] 2,2 DIPHENYLCYCLOPENTAN 1 ONE; 5 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 2,2 DI PHENYLCYCLOPENTAN 1 OL; 5 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 2,2 DIPHENYLCYCLOPENTAN 1 OL; 5 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 2,2 DIPHENYLCYCLOPENTAN 1 ONE; 5 [[[2 (2 METHOXYPHENOXY)ETHYL]AMINO]METHYL] 2,2 DIPHENYLCYCLOPENTAN 1 OL; 5 [[[2 (2 METHOXYPHENOXY)ETHYL]AMINO]METHYL] 2,2 DIPHENYLCYCLOPENTAN 1 ONE; [(5,5 DIPHENYLOXOLAN 2 YL)METHYL](2 PHENOXYETHYL)AMINE; [(5,5 DIPHENYLOXOLAN 2 YL)METHYL][2 (2 METHOXYPHENOXY)ETHYL]AMINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; PIPERAZINE DERIVATIVE; PROP 2 EN 1 YL 2 IODOACETATE(ALLYLIODOACETATE); SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; RAT;

ANIMALS; AORTA, THORACIC; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CYCLOPENTANES; DRUG PARTIAL AGONISM; FURANS; HELA CELLS; HUMANS; LIGANDS; MALE; MODELS, MOLECULAR; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SPLEEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 84855847535     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200421e     Document Type: Article

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