Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis

Journal of Trauma - Injury, Infection and Critical Care

Volumn 62, Issue 1, 2007, Pages 104-111

  Deree, Jessica ^a   Martins, Joilson O ^a   Leedom, Alex ^a   Lamon, Brian ^a   Putnam, James ^a   De Campos, Tercio ^a   Hoyt, David B ^a   Wolf, Paul ^a   Coimbra, Raul ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NONE   (United States)

Author keywords

Acute lung injury; Hemeoxygenase 1; Hemorrhagic shock; Hypertonic saline; Inflammation; Interleukin 8; Matrix metalloproteinases; Pentoxifylline

Indexed keywords

CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; GELATINASE A; GELATINASE B; HEME OXYGENASE 1; PENTOXIFYLLINE; RINGER LACTATE SOLUTION; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEGRANULATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HEMORRHAGIC SHOCK; IMMUNOHISTOCHEMISTRY; LEUKOCYTE ACTIVATION; LUNG LAVAGE; LUNG PARENCHYMA; MACROPHAGE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RESPIRATORY EPITHELIUM; RESUSCITATION; SYNTHESIS; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL DEGRANULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUID THERAPY; HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; LUNG; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MONOCYTE CHEMOATTRACTANT PROTEINS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PENTOXIFYLLINE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT; SALINE SOLUTION, HYPERTONIC; SHOCK, HEMORRHAGIC;

EID: 33846203391     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31802d96cb     Document Type: Article

References (48)

1. Coimbra R, Melbostad H, Hoyt DB. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma. 2004;56:442-449.
2. Deitch EA, Bridges W, Berg R, et al. Hemorrhagic shock-induced bacterial translocation: the role of neutrophils and hydroxyl radicals. J Trauma. 1990;30:942-952.
3. Ware LB, Mathay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349.
4. Lee WL, Downey GP. Neutrophil activation and acute lung injury. Curr Opin Crit Care. 2001;7:1-7.
5. Lanchou J, Corbel M, Tanguy M, et al. Imbalance between matrix metalloproteinases (MMP-2 and MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in acute respiratory syndrome patients. Crit Care Med. 2003;31:536-542.
6. Aldridge AJ. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg. 2002;168:204-214.
7. Rinaldo JE. Mediation of ARDS by leukocytes: clinical evidence and implications for therapy. Chest. 1986;89:590-593.
8. Usatyuk PV, Natarajan V. Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal adhesion kinase and adherens junction proteins. Am J Physiol Lung Cell Mol Physiol. 2002;289:999-1010.
9. Herbert CA, Baker JB. Interleukin-8: a review. Cancer Invest. 1993;1:743-750.
10. Donnelly SC, Streiter RM, Kunkel SL, et al. Interleukin-8 and the development of acute respiratory distress syndrome in at-risk patient groups. Lancet. 1993;341:643-647.
11. Corbel M, Boichot E, Lagente V. Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury. Braz J Med Biol Res. 2000;33:749-754.
12. Torii K, Iida K, Miyazaki Y, et al. Higher concentrations of matrix metalloproteinases in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997;155:43-46.
13. Ryter SW, Otterbein LO, Morse D, et al. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biol. 2002;234:249-263.
14. Maeshima K, Takahashi T, Uehara K, et al. Prevention of hemorrhagic shock-induced lung injury by heme arginate treatments in rats. Biochem Pharmacol. 2005;69:1667-1680.
15. Boutros CN, Zegdi R, Lila N, et al. Pulmonary expression of inducible heme-oxygenase after ischemia/reperfusion of the lower extremities in rats. J Surg Res. 2005;129:306-312.
16. Rhee P, Burris D, Kaufmann C, et al. Lactated Ringer's solution resuscitation causes neutrophil activation after hemorrhagic shock. J Trauma. 1998;44:313-319.
17. Savage S, Fitzpatrick CM, Kashyap VS, et al. Endothelial dysfunction after Lactated Ringer's solution resuscitation for hemorrhagic shock. J Trauma. 2005;59:284-290.
18. Rhee P, Wang D, Ruff P, et al. Human neutrophil activation and increased adhesion by various resuscitation fluids. Crit Care Med. 1998;28:74-78.
19. Pascual JL, Ferri LE, Seely AJE, et al. Hypertonic saline resuscitation of hemorrhagic shock diminishes neutrophil rolling and adherence to endothelium and reduces in vivo vascular leakage. Ann Surg. 2002;236:634-642.
20. Alam HB, Sun L, Ruff P, et al. E- and P-selectin expression depends on the resuscitation fluid used in hemorrhagic rats. J Surg Res. 2000;94:145-152.
21. Angle N, Hoyt DB, Liu F, et al. Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock. 1998;9:164-170.
22. Shi HP, Deitch EA, Xu DZ, et al. Hypertonic saline improves intestinal mucosa barrier function and lung injury after traumahemorrhagic shock. Shock. 2002;17:496-501.
23. Van Leenen D, Van der Poll T, Levi M, et al. Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees. J Immunol. 1993;151:2318-2325.
24. Michetti C, Coimbra R, Hoyt DB, et al. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res. 2003;115:92-99.
25. Coe DA, Freischlag JA, Johnson D, et al. Pentoxifylline prevents endothelial damage due to ischemia and reperfusion injury. J Surg Res. 1997;67:21-25.
26. Barroso-Aranda J, Schmid-Schonbein GW. Pentoxifylline pretreatment decreases the pool of circulating activated neutrophils, in-vivo adhesion to endothelium, and improves survival from hemorrhagic shock. Biorheology. 1990;27:401-418.
27. Coimbra R, Loomis W, Melbostad H, et al. Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy. J Trauma. 2005;59:257-265.
28. Coimbra R, Porcides R, Loomis W, et al. HSPTX protects against hemorrhagic shock resuscitation-induced tissue injury: an attractive alternative to Ringer's lactate. J Trauma. 2006;60:41-51.
29. Koustova E, Stanton K, Gushchin V, et al. Effects of lactated Ringer's solutions on human leukocytes. J Trauma. 2002;52:872-878.
30. Bauer M, Bauer I. Heme-oxygenase-1: redox regulation and role in the hepatic response to oxidative stress. Antioxid Redox Signal. 2002;4:749-758.
31. Botha AJ, Moore FA, Moore EE, et al. Sequential systemic platelet-activating factor and interleukin-8 primes neutrophils ion patients with trauma at risk of multiple organ failure. Br J Surg. 1996;83:1407-1412.
32. Mukaida N, Matsumoto T, Yokoi K, et al. Inhibition of neutrophil mediated acute inflammatory injury by an antibody against interleukin-8. Inflamm Res. 1998;3:S151-S157.
33. Steinberg J, Halter J, Schiller HJ, et al. Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. J Surg Res. 2003;15:185-195.
34. Carney DE, McCann UG, Schiller HJ, et al. Metalloproteinase inhibition prevents acute respiratory distress syndrome. J Surg Res. 2001;99:245-252.
35. Chakrabarti S, Patel KD. Regulation of matrix metaloproteinase-9 release from IL-8-stimulated human neutrophils. J Leuk Biol. 2005;78:279-288.
36. Van den Steen PE, Proost P, Wuyts A, et al. Neutrophil gelatinase B potentiated interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact. Blood. 2000;96:2673-2681.
37. Mazzoni MC, Borgstrom P, Intaglietta M, et al. Capillary narrowing in hemorrhagic shock is rectified by hyperosmotic saline-dextran reinfusion. Circ Shock. 1990;31:407-418.
38. Yada-Langui MM, Anjos-Valotta EA, Sannomiya P, et al. Resuscitation affects microcirculatory polymorphonuclear leukocyte behavior: role of hypertonic saline and pentoxifylline. Exp Biol Med. 2004;229:684-693.
39. Coimbra R, Razuk-Filho A, Yada-Langui MM, et al. Intraarterial pulmonary pentoxifylline improves cardiac performance and oxygen utilization after hemorrhagic shock: a novel resuscitation strategy. Anesth Analg. 2004;98:1439-1446.
40. Coimbra R, Loomis W, Melbostad H, et al. LPS-stimulated PMN activation and pro-inflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline. J Trauma. 2004;57:1157-1163.
41. Rizoli SB, Kapus A, Parodo J, et al. Hypertonicity prevents lipopolysaccharide-stimulated CD11b/CD18 expression in human neutrophils in vitro: role for p38 inhibition. J Trauma. 1999;46:794-798.
42. Guschin V, Stegalkina S, Alam HB, et al. Cytokine expression profiling in human leukocytes after exposure to hypertonic and isotonic fluids. J Trauma. 2002;52:867-871.
43. Moon PF, Kramer GC. Hypertonic-saline dextran resuscitation from hemorrhagic shock induces transient mixed acidosis. Crit Care Med. 1995;23:323-331.
44. Thomas TD, Karnik S, Balasubramanian KA. Surgical manipulation of the small intestine and its effect on the lung. J Surg Res. 2002;106:145-156.
45. Johnston TD, Fischer R, Chen Y, et al. Lung injury from gut ischemia: insensitivity to portal blood flow diversion. J Trauma. 1993;35:508-511.
46. Magnotti LJ, Upperman JS, Xu DZ, et al. Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg. 1998;228:518-527.
47. Yada-Langui MM, Coimbra R, Lancellotti C, et al. Hypertonic saline and pentoxifylline prevent lung injury and bacterial translocation after hemorrhagic shock. Shock. 2000;14:594-568.
48. Cruz RJ Jr, Yada-Langui MM, de Figueiredo LF, et al. The synergistic effects of pentoxifylline on systemic and regional perfusion after hemorrhage and hypertonic resuscitation. Anesth Analg. 2006;102:1518-1524.