Cytokines in rotator cuff degeneration and repair

Journal of Shoulder and Elbow Surgery

Volumn 21, Issue 2, 2012, Pages 218-227

  Bedi, Asheesh ^a   Maak, Travis ^b   Walsh, Christopher ^a   Rodeo, Scott A ^b   Grande, Dan ^c   Dines, David M ^b,c   Dines, Joshua S ^b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

Bone morphogenetic proteins; Cytokines; Growth factors; Inflammation; Review Article; Rotator cuff injury; Tendinopathy

Indexed keywords

ANTIINFLAMMATORY AGENT; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 2; CELECOXIB; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGENASE 3; CYTOKINE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GROWTH DIFFERENTIATION FACTOR 6; INDOMETACIN; MATRIX METALLOPROTEINASE; NICOTINE; NONSTEROID ANTIINFLAMMATORY AGENT; OSTEOGENIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN BCL 2; PROTEIN BNIP3; SOMATOMEDIN C; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; UNINDEXED DRUG; VASCULOTROPIN; VON WILLEBRAND FACTOR;

APOPTOSIS; DIABETES MELLITUS; FIBROCARTILAGE; FRACTURE HEALING; GENE EXPRESSION; GENE THERAPY; HEALING; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; ROTATOR CUFF INJURY; STEM CELL; TENDINITIS; TENDON RECONSTRUCTION;

ANIMALS; APOPTOSIS; BIOPSY, NEEDLE; BONE MORPHOGENETIC PROTEINS; CYTOKINES; DISEASE PROGRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; PLATELET-DERIVED GROWTH FACTOR; ROTATOR CUFF; SHEEP; SHOULDER JOINT; TENDINOPATHY; TENDON INJURIES; WOUND HEALING;

EID: 84855832166     PISSN: 10582746     EISSN: 15326500     Source Type: Journal    
DOI: 10.1016/j.jse.2011.09.020     Document Type: Review

References (113)

1. Abrahamsson S.O. Matrix metabolism and healing in the flexor tendon. Experimental studies on rabbit tendon. Scand J Plast Reconstr Surg Hand Surg Suppl 1991, 23:1-51.
2. Abrahamsson S.O., Lohmander S. Differential effects of insulin-like growth factor-I on matrix and DNA synthesis in various regions and types of rabbit tendons. J Orthop Res 1996, 14:370-376. 10.1002/jor.1100140305.
3. Abrahamsson S.O., Lundborg G., Lohmander L.S. Long-term explant culture of rabbit flexor tendon: effects of recombinant human insulin-like growth factor-I and serum on matrix metabolism. J Orthop Res 1991, 9:503-515. 10.1002/jor.1100090406.
4. Abrahamsson S.O., Lundborg G., Lohmander L.S. Recombinant human insulin-like growth factor-I stimulates invitro matrix synthesis and cell proliferation in rabbit flexor tendon. J Orthop Res 1991, 9:495-502. 10.1002/jor.1100090405.
5. Arner O., Lindholm A. Subcutaneous rupture of the Achilles tendon; a study of 92 cases. Acta Chir Scand Suppl 1959, 116(Suppl 239):1-51.
6. Aspenberg P., Forslund C. Bone morphogenetic proteins and tendon repair. Scand J Med Sci Sports 2000, 10:372-375.
7. Aspenberg P., Forslund C. Enhanced tendon healing with GDF 5 and 6. Acta Orthop Scand 1999, 70:51-54.
8. Axelrad T.W., Einhorn T.A. Bone morphogenetic proteins in orthopaedic surgery. Cytokine Growth Factor Rev 2009, 20:481-488. 10.1016/j.cytogfr.2009.10.003.
9. Bedi A., Fox A.J., Harris P.E., Deng X.H., Ying L., Warren R.F., et al. Diabetes mellitus impairs tendon-bone healing after rotator cuff repair. J Shoulder Elbow Surg 2010, 19:978-988. 10.1016/j.jse.2009.11.045.
10. Bedi A., Fox A.J., Kovacevic D., Deng X.H., Warren R.F., Rodeo S.A. Doxycycline-mediated inhibition of matrix metalloproteinases improves healing after rotator cuff repair. Am J Sports Med 2010, 38:308-317. 10.1177/0363546509347366.
11. Bedi A., Kovacevic D., Hettrich C., Gulotta L.V., Ehteshami J.R., Warren R.F., et al. The effect of matrix metalloproteinase inhibition on tendon-to-bone healing in a rotator cuff repair model. J Shoulder Elbow Surg 2010, 19:384-391. 10.1016/j.jse.2009.07.010.
12. Benson R.T., McDonnell S.M., Knowles H.J., Rees J.L., Carr A.J., Hulley P.A. Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis. J Bone Joint Surg Br 2010, 92:448-453. 10.1302/0301-620X.92B3.23074.
13. Biberthaler P., Wiedemann E., Nerlich A., Kettler M., Mussack T., Deckelmann S., et al. Microcirculation associated with degenerative rotator cuff lesions. Invivo assessment with orthogonal polarization spectral imaging during arthroscopy of the shoulder. J Bone Joint Surg Am 2003, 85:475-480.
14. Bidder M., Towler D.A., Gelberman R.H., Boyer M.I. Expression of mRNA for vascular endothelial growth factor at the repair site of healing canine flexor tendon. J Orthop Res 2000, 18:247-252. 10.1002/jor.1100180212.
15. Birkedal-Hansen H., Yamada S., Windsor J., Pollard A.H., Lyons G., Stetler-Stevenson W., et al. Matrix metalloproteinases. Curr Protoc Cell Biol 2008, Chapter 10:Unit 10.8. doi:10.1002/0471143030.cb1008s40.
16. Bishop J., Klepps S., Lo I.K., Bird J., Gladstone J.N., Flatow E.L. Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study. J Shoulder Elbow Surg 2006, 15:290-299.
17. Blevins F.T., Djurasovic M., Flatow E.L., Vogel K.G. Biology of the rotator cuff tendon. Orthop Clin North Am 1997, 28:1-16.
18. Boyer M.I., Watson J.T., Lou J., Manske P.R., Gelberman R.H., Cai S.R. Quantitative variation in vascular endothelial growth factor mRNA expression during early flexor tendon healing: an investigation in a canine model. J Orthop Res 2001, 19:869-872. 10.1016/S0736-0266(01)00017-1.
19. Campbell B.H., Agarwal C., Wang J.H. TGF-beta1, TGF-beta3, and PGE(2) regulate contraction of human patellar tendon fibroblasts. Biomech Model Mechanobiol 2004, 2:239-245. 10.1007/s10237-004-0041-z.
20. Canalis E., Centrella M., McCarthy T. Effects of basic fibroblast growth factor on bone formation invitro. J Clin Invest 1988, 81:1572-1577. 10.1172/JCI113490.
21. Carpenter J.E., Thomopoulos S., Flanagan C.L., DeBano C.M., Soslowsky L.J. Rotator cuff defect healing: a biomechanical and histologic analysis in an animal model. J Shoulder Elbow Surg 1998, 7:599-605.
22. Chan B.P., Chan K.M., Maffulli N., Webb S., Lee K.K. Effect of basic fibroblast growth factor. An invitro study of tendon healing. Clin Orthop Relat Res 1997, 239-247.
23. Chan B.P., Fu S., Qin L., Lee K., Rolf C.G., Chan K. Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: a rat patellar tendon model. Acta Orthop Scand 2000, 71:513-518. 10.1080/000164700317381234.
24. Chan B.P., Fu S.C., Qin L., Rolf C., Chan K.M. Supplementation-time dependence of growth factors in promoting tendon healing. Clin Orthop Relat Res 2006, 448:240-247. 10.1097/01.blo.0000205875.97468.e4.
25. Chang J., Most D., Stelnicki E., Siebert J.W., Longaker M.T., Hui K., et al. Gene expression of transforming growth factor beta-1 in rabbit zone II flexor tendon wound healing: evidence for dual mechanisms of repair. Plast Reconstr Surg 1997, 100:937-944.
26. Chang J., Most D., Thunder R., Mehrara B., Longaker M.T., Lineaweaver W.C. Molecular studies in flexor tendon wound healing: the role of basic fibroblast growth factor gene expression. JHand Surg Am 1998, 23:1052-1058. 10.1016/S0363-5023(98)80015-4.
27. Chard M.D., Cawston T.E., Riley G.P., Gresham G.A., Hazleman B.L. Rotator cuff degeneration and lateral epicondylitis: a comparative histological study. Ann Rheum Dis 1994, 53:30-34.
28. Cohen D.B., Kawamura S., Ehteshami J.R., Rodeo S.A. Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing. Am J Sports Med 2006, 34:362-369. 10.1177/0363546505280428.
29. Dahlgren L.A., Mohammed H.O., Nixon A.J. Temporal expression of growth factors and matrix molecules in healing tendon lesions. JOrthop Res 2005, 23:84-92.
30. Dahlgren L.A., Nixon A.J., Brower-Toland B.D. Effects of beta-aminopropionitrile on equine tendon metabolism invitro and on effects of insulin-like growth factor-I on matrix production by equine tenocytes. Am J Vet Res 2001, 62:1557-1562.
31. Dahlgren L.A., van der Meulen M.C., Bertram J.E., Starrak G.S., Nixon A.J. Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis. J Orthop Res 2002, 20:910-919. 10.1016/S0736-0266(02)00009-8.
32. Dines J.S., Bedi A., ElAttrache N.S., Dines D.M. Single-row versus double-row rotator cuff repair: techniques and outcomes. J Am Acad Orthop Surg 2010, 18:83-93.
33. Dines J.S., Cross M.B., Dines D., Pantazopoulos C., Kim H.J., Razzano P., et al. Invitro analysis of an rhGDF-5 suture coating process and the effects of rhGDF-5 on rat tendon fibroblasts. Growth Factors 2011, 29:1-7. 10.3109/08977194.2010.526605.
34. Dines J.S., Weber L., Razzano P., Prajapati R., Timmer M., Bowman S., et al. The effect of growth differentiation factor-5-coated sutures on tendon repair in a rat model. J Shoulder Elbow Surg 2007, 16(5 Suppl):S215-S221. 10.1016/j.jse.2007.03.001.
35. Fealy S., Adler R.S., Drakos M.C., Kelly A.M., Allen A.A., Cordasco F.A., et al. Patterns of vascular and anatomical response after rotator cuff repair. Am J Sports Med 2006, 34:120-127. 10.1177/0363546505280212.
36. Forslund C., Aspenberg P. Improved healing of transected rabbit Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2. Am J Sports Med 2003, 31:555-559.
37. Forslund C., Aspenberg P. Tendon healing stimulated by injected CDMP-2. Med Sci Sports Exerc 2001, 33:685-687.
38. Forslund C., Rueger D., Aspenberg P. A comparative dose-response study of cartilage-derived morphogenetic protein (CDMP)-1, -2 and -3 for tendon healing in rats. J Orthop Res 2003, 21:617-621. 10.1016/S0736-0266(03)00010-X.
39. Franceschi F., Longo U.G., Ruzzini L., Rizzello G., Denaro V. Arthroscopic management of calcific tendinitis of the subscapularis tendon. Knee Surg Sports Traumatol Arthrosc 2007, 15:1482-1485. 10.1007/s00167-007-0340-x.
40. Franceschi F., Ruzzini L., Longo U.G., Martina F.M., Zobel B.B., Maffulli N., et al. Equivalent clinical results of arthroscopic single-row and double-row suture anchor repair for rotator cuff tears: a randomized controlled trial. Am J Sports Med 2007, 35:1254-1260. 10.1177/0363546507302218.
41. Fukuda H., Hamada K., Yamanaka K. Pathology and pathogenesis of bursal-side rotator cuff tears viewed from en bloc histologic sections. Clin Orthop Relat Res 1990, 75-80.
42. Galatz L., Rothermich S., VanderPloeg K., Petersen B., Sandell L., Thomopoulos S. Development of the supraspinatus tendon-to-bone insertion: localized expression of extracellular matrix and growth factor genes. J Orthop Res 2007, 25:1621-1628. 10.1002/jor.20441.
43. Galatz L.M., Ball C.M., Teefey S.A., Middleton W.D., Yamaguchi K. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am 2004, 86:219-224.
44. Galatz L.M., Silva M.J., Rothermich S.Y., Zaegel M.A., Havlioglu N., Thomopoulos S. Nicotine delays tendon-to-bone healing in a rat shoulder model. J Bone Joint Surg Am 2006, 88:2027-2034. 10.2106/JBJS.E.00899.
45. Gerber C., Schneeberger A.G., Perren S.M., Nyffeler R.W. Experimental rotator cuff repair. A preliminary study. J Bone Joint Surg Am 1999, 81:1281-1290.
46. Gospodarowicz D., Neufeld G., Schweigerer L. Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells. Cell Differ 1986, 19:1-17.
47. Harwood F.L., Goomer R.S., Gelberman R.H., Silva M.J., Amiel D. Regulation of alpha(v)beta3 and alpha5beta1 integrin receptors by basic fibroblast growth factor and platelet-derived growth factor-BB in intrasynovial flexor tendon cells. Wound Repair Regen 1999, 7:381-388. 10.1046/j.1524-475X.1999.00381.x.
48. Hashimoto T., Nobuhara K., Hamada T. Pathologic evidence of degeneration as a primary cause of rotator cuff tear. Clin Orthop Relat Res 2003, 111-120.
49. Hays P.L., Kawamura S., Deng X.H., Dagher E., Mithoefer K., Ying L., et al. The role of macrophages in early healing of a tendon graft in a bone tunnel. J Bone Joint Surg Am 2008, 90:565-579. 10.2106/JBJS.F.00531.
50. Hee C.K., Dines J.S., Dines D.M., Roden C.M., Wisner-Lynch L.A., Turner A.S., et al. Augmentation of a rotator cuff suture repair using rhPDGF-BB and a type I bovine collagen matrix in an ovine model. Am J Sports Med 2011, 39:1630-1639. 10.1177/0363546511404942.
51. Hildebrand K.A., Woo S.L., Smith D.W., Allen C.R., Deie M., Taylor B.J., et al. The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament. An invivo study. Am J Sports Med 1998, 26:549-554.
52. Ide J., Kikukawa K., Hirose J., Iyama K., Sakamoto H., Fujimoto T., et al. The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon. J Shoulder Elbow Surg 2009, 18:391-398. 10.1016/j.jse.2009.01.013.
53. Ide J., Kikukawa K., Hirose J., Iyama K., Sakamoto H., Mizuta H. The effects of fibroblast growth factor-2 on rotator cuff reconstruction with acellular dermal matrix grafts. Arthroscopy 2009, 25:608-616. 10.1016/j.arthro.2008.11.011.
54. Jost B., Pfirrmann C.W., Gerber C., Switzerland Z. Clinical outcome after structural failure of rotator cuff repairs. J Bone Joint Surg Am 2000, 82:304-314.
55. Kannus P., Jozsa L. Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. J Bone Joint Surg Am 1991, 73:1507-1525.
56. Kashiwagi K., Mochizuki Y., Yasunaga Y., Ishida O., Deie M., Ochi M. Effects of transforming growth factor-beta 1 on the early stages of healing of the Achilles tendon in a rat model. Scand J Plast Reconstr Surg Hand Surg 2004, 38:193-197. 10.1080/02844310410029110.
57. Khan U., Occleston N.L., Khaw P.T., McGrouther D.A. Differences in proliferative rate and collagen lattice contraction between endotenon and synovial fibroblasts. J Hand Surg Am 1998, 23:266-273. 10.1016/S0363-5023(98)80125-1.
58. Khanna A., Nelmes R.T., Gougoulias N., Maffulli N., Gray J. The effects of LIPUS on soft-tissue healing: a review of literature. Br Med Bull 2009, 89:169-182. 10.1093/bmb/ldn040.
59. Kim H.M., Galatz L.M., Das R., Havlioglu N., Rothermich S.Y., Thomopoulos S. The role of transforming growth factor beta isoforms in tendon-to-bone healing. Connect Tissue Res 2011, 52:87-98. 10.3109/03008207.2010.483026.
60. Kim H.J., Kang S.W., Lim H.C., Han S.B., Lee J.S., Prasad L., et al. The role of transforming growth factor-beta and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury. Connect Tissue Res 2007, 48:309-315.
61. Klein M.B., Yalamanchi N., Pham H., Longaker M.T., Chang J. Flexor tendon healing invitro: effects of TGF-beta on tendon cell collagen production. J Hand Surg Am 2002, 27:615-620. 10.1053/jhsu.2002.34004.
62. Kobayashi M., Itoi E., Minagawa H., Miyakoshi N., Takahashi S., Tuoheti Y., et al. Expression of growth factors in the early phase of supraspinatus tendon healing in rabbits. J Shoulder Elbow Surg 2006, 15:371-377. 10.1016/j.jse.2005.09.003.
63. Kovacevic D., Fox A.J., Bedi A., Ying L., Deng X.H., Warren R.F., et al. Calcium-phosphate matrix with or without TGF-beta3 improves tendon-bone healing after rotator cuff repair. Am J Sports Med 2011, 39:811-819. 10.1177/0363546511399378.
64. Kurtz C.A., Loebig T.G., Anderson D.D., DeMeo P.J., Campbell P.G. Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model. Am J Sports Med 1999, 27:363-369.
65. Letson A.K., Dahners L.E. The effect of combinations of growth factors on ligament healing. Clin Orthop Relat Res 1994, 207-212.
66. Lo I.K., Marchuk L.L., Hollinshead R., Hart D.A., Frank C.B. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons. Am J Sports Med 2004, 32:1223-1229. doi:0.1177/0363546503262200.
67. Longo U.G., Franceschi F., Ruzzini L., Rabitti C., Morini S., Maffulli N., et al. Histopathology of the supraspinatus tendon in rotator cuff tears. Am J Sports Med 2008, 36:533-538. 10.1177/036354650730854.
68. Lories R.J., Luyten F.P. Bone morphogenetic protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev 2005, 16:287-298. 10.1016/j.cytogfr.2005.02.009.
69. Lu H., Qin L., Fok P., Cheung W., Lee K., Guo X., et al. Low-intensity pulsed ultrasound accelerates bone-tendon junction healing: a partial patellectomy model in rabbits. Am J Sports Med 2006, 34:1287-1296. 10.1177/0363546506286788.
70. Lou J., Tu Y., Burns M., Silva M.J., Manske P. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res 2001, 19:1199-1202. 10.1016/S0736-0266(01)00042-0.
71. Lu H., Qin L., Cheung W., Lee K., Wong W., Leung K. Low-intensity pulsed ultrasound accelerated bone-tendon junction healing through regulation of vascular endothelial growth factor expression and cartilage formation. Ultrasound Med Biol 2008, 34:1248-1260. 10.1016/j.ultrasmedbio.2008.01.009.
72. Magra M., Maffulli N. Matrix metalloproteases: a role in overuse tendinopathies. Br J Sports Med 2005, 39:789-791. 10.1136/bjsm.2005.017855.
73. Manning C.N., Kim H.M., Sakiyama-Elbert S., Galatz L.M., Havlioglu N., Thomopoulos S. Sustained delivery of transforming growth factor beta three enhances tendon-to-bone healing in a rat model. J Orthop Res 2011, 29:1099-1105. 10.1002/jor.21301.
74. Matthews T.J., Hand G.C., Rees J.L., Athanasou N.A., Carr A.J. Pathology of the torn rotator cuff tendon. Reduction in potential for repair as tear size increases. J Bone Joint Surg Br 2006, 88:489-495.
75. Meislin R.J., Sperling J.W., Stitik T.P. Persistent shoulder pain: epidemiology, pathophysiology, and diagnosis. Am J Orthop (Belle Mead NJ) 2005, 34(12 Suppl):5-9.
76. Millar N.L., Bradley T.A., Walsh N.A., Appleyard R.C., Tyler M.J., Murrell G.A. Frog glue enhances rotator cuff repair in a laboratory cadaveric model. J Shoulder Elbow Surg 2009, 18:639-645. 10.1016/j.jse.2008.12.007.
77. Millar N.L., Hueber A.J., Reilly J.H., Xu Y., Fazzi U.G., Murrell G.A., et al. Inflammation Is present in early human tendinopathy. Am J Sports Med 2010, 38:2085-2091. 10.1177/0363546510372613.
78. Millar N.L., Wei A.Q., Molloy T.J., Bonar F., Murrell G.A. Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg Br 2009, 91:417-424. 10.1302/0301-620X.91B3.21652.
79. Molloy T.J., Kemp M.W., Wang Y., Murrell G.A. Microarray analysis of the tendinopathic rat supraspinatus tendon: glutamate signaling and its potential role in tendon degeneration. J Appl Physiol 2006, 101:1702-1709. 10.1152/japplphysiol.00386.2006.
80. Murray D.H., Kubiak E.N., Jazrawi L.M., Araghi A., Kummer F., Loebenberg M.I., et al. The effect of cartilage-derived morphogenetic protein 2 on initial healing of a rotator cuff defect in a rat model. JShoulder Elbow Surg 2007, 16:251-254. 10.1016/j.jse.2006.07.002.
81. Murray M.M., Spindler K.P., Ballard P., Welch T.P., Zurakowski D., Nanney L.B. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 2007, 25:1007-1017. 10.1002/jor.20367.
82. Nakamura N., Shino K., Natsuume T., Horibe S., Matsumoto N., Kaneda Y., et al. Early biological effect of invivo gene transfer of platelet-derived growth factor (PDGF)-B into healing patellar ligament. Gene Ther 1998, 5:1165-1170. 10.1038/sj.gt.3300712.
83. Nakamura N., Timmermann S.A., Hart D.A., Kaneda Y., Shrive N.G., Shino K., et al. A comparison of invivo gene delivery methods for antisense therapy in ligament healing. Gene Ther 1998, 5:1455-1461. 10.1038/sj.gt.3300765.
84. Nakase T., Sugamoto K., Miyamoto T., Tsumaki N., Luyten F.P., Inui H., et al. Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff. Clin Orthop Relat Res 2002, 140-145.
85. Paoloni J.A., Appleyard R.C., Nelson J., Murrell G.A. Topical glyceryl trinitrate application in the treatment of chronic supraspinatus tendinopathy: a randomized, double-blinded, placebo-controlled clinical trial. Am J Sports Med 2005, 33:806-813. 10.1177/0363546504270998.
86. Paoloni J.A., Murrell G.A., Burch R.M., Ang R.Y. Randomised, double-blind, placebo-controlled clinical trial of a new topical glyceryl trinitrate patch for chronic lateral epicondylosis. Br J Sports Med 2009, 43:299-302. 10.1136/bjsm.2008.053108.
87. Perry S.M., McIlhenny S.E., Hoffman M.C., Soslowsky L.J. Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg 2005, 14(1 Suppl S):79S-83S. 10.1016/j.jse.2004.09.020.
88. Petersen W., Pufe T., Unterhauser F., Zantop T., Mentlein R., Weiler A. The splice variants 120 and 164 of the angiogenic peptide vascular endothelial cell growth factor (VEGF) are expressed during Achilles tendon healing. Arch Orthop Trauma Surg 2003, 123:475-480. 10.1007/s00402-003-0490-3.
89. Petersen W., Unterhauser F., Pufe T., Zantop T., Sudkamp N.P., Weiler A. The angiogenic peptide vascular endothelial growth factor (VEGF) is expressed during the remodeling of free tendon grafts in sheep. Arch Orthop Trauma Surg 2003, 123:168-174. 10.1007/s00402-002-0462-z.
90. Qin L., Lu H., Fok P., Cheung W., Zheng Y., Lee K., et al. Low-intensity pulsed ultrasound accelerates osteogenesis at bone-tendon healing junction. Ultrasound Med Biol 2006, 32:1905-1911. 10.1016/j.ultrasmedbio.2006.06.028.
91. Rickert M., Jung M., Adiyaman M., Richter W., Simank H.G. A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats. Growth Factors 2001, 19:115-126.
92. Rickert M., Wang H., Wieloch P., Lorenz H., Steck E., Sabo D., et al. Adenovirus-mediated gene transfer of growth and differentiation factor-5 into tenocytes and the healing rat Achilles tendon. Connect Tissue Res 2005, 46:175-183. 10.1080/03008200500237120.
93. Rodeo S.A., Arnoczky S.P., Torzilli P.A., Hidaka C., Warren R.F. Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog. J Bone Joint Surg Am 1993, 75:1795-1803.
94. Rodeo S.A., Potter H.G., Kawamura S., Turner A.S., Kim H.J., Atkinson B.L. Biologic augmentation of rotator cuff tendon-healing with use of a mixture of osteoinductive growth factors. J Bone Joint Surg Am 2007, 89:2485-2497. 10.2106/JBJS.J.00184.
95. Sano H., Ishii H., Yeadon A., Backman D.S., Brunet J.A., Uhthoff H.K. Degeneration at the insertion weakens the tensile strength of the supraspinatus tendon: a comparative mechanical and histologic study of the bone-tendon complex. J Orthop Res 1997, 15:719-726. 10.1002/jor.1100150514.
96. Sano H., Uhthoff H.K., Backman D.S., Brunet J.A., Trudel G., Pham B., et al. Structural disorders at the insertion of the supraspinatus tendon. Relation to tensile strength. J Bone Joint Surg Br 1998, 80:720-725.
97. Schlegel T.F., Hawkins R.J., Lewis C.W., Motta T., Turner A.S. The effects of augmentation with Swine small intestine submucosa on tendon healing under tension: histologic and mechanical evaluations in sheep. Am J Sports Med 2006, 34:275-280. 10.1177/0363546505279912.
98. Seeherman H.J., Archambault J.M., Rodeo S.A., Turner A.S., Zekas L., D'Augusta D., et al. rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model. J Bone Joint Surg Am 2008, 90:2206-2219. 10.2106/JBJS.G.00742.
99. Spindler K.P., Murray M.M., Detwiler K.B., Tarter J.T., Dawson J.M., Nanney L.B., et al. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res 2003, 21:245-249.
100. Sporn M.B., Roberts A.B., Wakefield L.M., Assoian R.K. Transforming growth factor-beta: biological function and chemical structure. Science 1986, 233:532-534.
101. Takahasih S., Nakajima M., Kobayashi M., Wakabayashi I., Miyakoshi N., Minagawa H., et al. Effect of recombinant basic fibroblast growth factor (bFGF) on fibroblast-like cells from human rotator cuff tendon. Tohoku J Exp Med 2002, 198:207-214.
102. Tang J.B., Cao Y., Zhu B., Xin K.Q., Wang X.T., Liu P.Y. Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength. an invivo study. J Bone Joint Surg Am 2008, 90:1078-1089. 10.2106/JBJS.F.01188.
103. Thomopoulos S., Harwood F.L., Silva M.J., Amiel D., Gelberman R.H. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis invitro. J Hand Surg Am 2005, 30:441-447. 10.1016/j.jhsa.2004.12.006.
104. Tsuzaki M., Brigman B.E., Yamamoto J., Lawrence W.T., Simmons J.G., Mohapatra N.K., et al. Insulin-like growth factor-I is expressed by avian flexor tendon cells. J Orthop Res 2000, 18:546-556. 10.1002/jor.1100180406.
105. Uggen C., Dines J., McGarry M., Grande D., Lee T., Limpisvasti O. The effect of recombinant human platelet-derived growth factor BB-coated sutures on rotator cuff healing in a sheep model. Arthroscopy 2010, 26:1456-1462. 10.1016/j.arthro.2010.02.025.
106. Virchenko O., Fahlgren A., Skoglund B., Aspenberg P. CDMP-2 injection improves early tendon healing in a rabbit model for surgical repair. Scand J Med Sci Sports 2005, 15:260-264. 10.1111/j.1600-0838.2005.00462.x.
107. Walsh W.R., Stephens P., Vizesi F., Bruce W., Huckle J., Yu Y. Effects of low-intensity pulsed ultrasound on tendon-bone healing in an intra-articular sheep knee model. Arthroscopy 2007, 23:197-204. 10.1016/j.arthro.2006.09.003.
108. Wolfman N.M., Hattersley G., Cox K., Celeste A.J., Nelson R., Yamaji N., et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest 1997, 100:321-330. 10.1172/JCI119537.
109. Wurgler-Hauri C.C., Dourte L.M., Baradet T.C., Williams G.R., Soslowsky L.J. Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model. J Shoulder Elbow Surg 2007, 16(5 Suppl):S198-S203. 10.1016/j.jse.2007.04.003.
110. Yamaguchi K., Ditsios K., Middleton W.D., Hildebolt C.F., Galatz L.M., Teefey S.A. The demographic and morphological features of rotator cuff disease. A comparison of asymptomatic and symptomatic shoulders. J Bone Joint Surg Am 2006, 88:1699-1704.
111. Yoshikawa Y., Abrahamsson S.O. Dose-related cellular effects of platelet-derived growth factor-BB differ in various types of rabbit tendons invitro. Acta Orthop Scand 2001, 72:287-292. 10.1080/00016470152846646.
112. Yuan J., Murrell G.A., Wei A.Q., Wang M.X. Apoptosis in rotator cuff tendonopathy. J Orthop Res 2002, 20:1372-1379. 10.1016/S0736-0266(02)00075-X.
113. Zhang F., Liu H., Stile F., Lei M.P., Pang Y., Oswald T.M., et al. Effect of vascular endothelial growth factor on rat Achilles tendon healing. Plast Reconstr Surg 2003, 112:1613-1619. 10.1097/01.PRS.0000086772.72535.A4.