The splice variants 120 and 164 of the angiogenic peptide vascular endothelial cell growth factor (VEGF) are expressed during Achilles tendon healing

Archives of Orthopaedic and Trauma Surgery

Volumn 123, Issue 9, 2003, Pages 475-480

  Petersen, Wolf ^a   Pufe, Thomas ^a   Unterhauser, Frank ^b   Zantop, Thore ^a   Mentlein, Rolf ^a   Weiler, Andreas ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Achilles tendon; Angiogenesis; Splice variants; Tendon healing; Vascular endothelial growth factor

Indexed keywords

ANGIOGENIC FACTOR; CHEMOTACTIC PEPTIDE; DISULFIDE; GLYCOSYLATED PROTEIN; LIPID; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ACHILLES TENDON RUPTURE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLOGY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEEP; SMOOTH MUSCLE FIBER; STATISTICAL ANALYSIS; TENDON INJURY; TENOTOMY; TISSUE REGENERATION; UPREGULATION; WOUND HEALING;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PHYSIOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; SHEEP; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 0344394240     PISSN: 09368051     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00402-003-0490-3     Document Type: Article

References (41)

1. Ahmed IM, Lagopoulos M, McConnel P, Soames RW, Sefton GK (1998) Blood supply of the Achilles tendon. J Orthop Res 16:591-596
2. Astrom M, Rausing A (1995) Chronic Achilles tendonopathy. A survey of surgical and histopathological findings. Clin Orthop 316:151-164
3. Astrom M, Westlin N (1994) Blood flow in chronic Achilles tendinopathy. Clin Orthop 308:166-172
4. Backman C, Boquist L, Friden J, Lorentzon R, Toolanen G (1990) Chronic Achilles paratendinosis with tendinosis: an experimental model in the rabbit. J Orthop Res 8:541-547
5. Backman C, Friden J, Widmark A (1991) Blood flow in chronic Achilles tendinosis: radioactive microsphere study in rabbits. Acta Orthop Scand 62:386-387
6. Bidder M, Towler DA, Gelberman RH, Boyer MI (2000) Expression of mRNA for vascular endothelial growth factor at the repair site of heating canine flexor tendon. J Orthop Res 18: 247-252
7. Callard R, Gearing A (1994) The cytokine facts book. Academic Press, London
8. Carlstedt CA, Madsen K, Wredmark T (1986) Biomechanical and biochemical studies of tendon healing after conservative and surgical treatment. Arch Orthop Trauma Surg 105:211-215
9. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kiekens L, Gerstenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declerq C, Pawling J, Moons L, Collen D, Risau W, Nagy A (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439
10. Carr AJ, Norris SH (1989) The blood supply of the calcaneal tendon. J Bone Joint Surg Br 71:100-101
11. Chang J, Most D, Thunder R, Mehrara B, Longaker MT, Lineaweaver WC (1998) Molecular studies in flexor tendon wound healing: the role of basic fibroblast growth factor gene expression. J Hand Surg 23:1052-1058
12. Cheung CY, Brace RA (1998) Ovine vascular endothelial growth factor: nucleotide sequence and expression in fetal tissues. Growth Factors 16:11-22
13. Eckhart L, Ban J, Ballaun C, Weniger W, Tschachler E (1999) Reverse transcription-polymerase chain reaction products of alternatively spliced mRNAs form heteroduplexes and heteroduplex complexes. J Biol Chem 274:2613-2615
14. Fava RA, Olsen NJ, Spencer-Green G, Yeo K-T, Yeo T-K, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF (1994) Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180:341-346
15. Feindt J, Becker I, Blömer U, Hugo H-H, Mehdorn HM, Krisch B, Mentlein R (1995) Expression of somatostatin receptor subtypes in cultured astrocytes and gliomas. J Neurochem 65: 1997-2005
16. Ferrara N (1999) Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77:527-543
17. Finkenzeller G, Sparacio A, Technau A, Marme D, Siemeister G (1997) Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene 15:669-676
18. Fong DH, Rossant J, Gersenstein M, Breitman ML (1995) Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70
19. Gerber HP, Vu TH, Ryan AM, Kolwalski J, Werb Z, Ferrara N (1999) VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5:623-628
20. Held-Feindt J, Krisch B, Mentlein R (1999) Molecular and functional analysis of the somatostatin receptor subtype 2 (sst2) in human glioma cells. Mol Brain Res 64:101-107
21. Hepp WR, Blauth W (1978) Repair of defects in the Achilles tendon with the peroneus brevis muscle. Arch Orthop Trauma Surg 91:195-200
22. Jarvinen M, Józsa, LG, Kannus, P, Jarvinen TL, Kvist M, Leadbetter W (1997) Histopathological findings in chronic tendon disorders. Scan J Med Sci Sports 7:86-95
23. Józsa LG, Kannus P (1997) Human tendons - anatomy, physiology, and pathology. Human Kinetics, London
24. Kannus P, Jozsa L (1991) Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 981 patients. J Bone Joint Surg Am 73:1507-1525
25. Koch S, Tillmann B (1995) The distal tendon of the biceps brachii: structure and clinical correlations. Ann Anat 177:467-474
26. Lang J (1960) Über das Gleitgewebe der Sehnen, Muskeln, Fascien und Gefäße. Z Anat Entwicklungsgesch 122:197-231
27. Lang J (1963) Über die Blutgefäße der Sehnenscheiden. Acta Anat 54:273-309
28. Messner K, Wei Y, Andersson B, Gillquist J, Rasanen T (1999) Rat model of Achilles tendon disorder. A pilot study. Cells Tissues Organs 165:30-39
29. Milanini J, Vinals F, Poussegur J, Pages G (1998) p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem 273:18165-18172
30. Movin T, Gad A, Reinholt FP, Rolf C (1997) Tendon pathology in long standing achillodynia. Biopsy findings in 40 patients. Acta Orthop Scand 68:170-175
31. Neufeld G, Cohen T, Gengrinovitch S, Poltrak Z (1999) Vascular endothelial growth factor and its receptors. FASEB J 13: 9-22
32. Petersen W, Stein V, Tillmann B (1999) Blood supply of the quadriceps tendon. Unfallchirurg 102:543-547
33. Petersen W, Stein V, Tillmann B (1999) Blood supply of the tibialis anterior tendon. Arch Orthop Trauma Surg 119:371-375
34. Petersen W, Bobka T, Stein V, Tillmann B (2000) Blood supply of the peroneal tendons: injection and immunohistochemical studies of cadaver tendons. Acta Orthop Scand 71:168-174
35. Pufe T, Petersen W, Tillmann B, Mentlein R (2001) The angiogenetic peptide vascular endothelial growth factor is expressed in foetal and ruptured tendons. Virchows Arch 439: 579-585
36. Pufe T, Petersen W, Tillmann B, Mentlein R (2001) Expression of the vascular endothelial growth factor in osteoarthritic cartilage. Arthritis Rheum 44:1082-1088
37. Pufe T, Petersen W, Tillmann B, Mentlein R (2001) The splice variants VEGF 121 and VEGF 165 are expressed in synovium of rheumatoid arthritis. J Rheumatol 28:1482-1486
38. Ryuto M, Ono M, Izumi H, Yoshida S, Weich HA, Kohno K, Kuwano M (1996) Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1. J Biol Chem 271:28220-28228
39. Shalaby F, Rossant J, Yamaguchi TP, Gerstenstein M, Wu XF, Breitman ML, Schuh AC (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66
40. Stavri GT, Zachary IC, Baskervillle PA, Martin JF, Erusalimsky JD (1995) Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic action with hypoxia. Circulation 92:11-14
41. Stein V. Laprell H, Tinnemeyer S, Petersen W (2000) Quantitative assessment of the intravascular volume of the human Achilles tendon. Acta Orthop Scand 181:313-314