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Bioorganic and Medicinal Chemistry

Volumn 20, Issue 2, 2012, Pages 1100-1112

Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH

(5) Rusch, Marion a Zahov, Stefan b Vetter, Ingrid R a Lehr, Matthias b Hedberg, Christian a

a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY (Germany)

b UNIVERSITY OF MÜNSTER (Germany)

Author keywords

2 Keto oxazole; Endocannabinoid; FAAH inhibitor; Fatty acid amide hydrolase; Pain

Indexed keywords

1 [5 [2 [3 (DIMETHYLAMINO)PROPYLSULFONYL]ETHYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [2 [3 (DIMETHYLAMINO)PROPYLSULFONYL]ETHYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [2 [3 (DIMETHYLAMINO)PROPYLTHIO]ETHYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [2 [3 (DIMETHYLAMINO)PROPYLTHIO]ETHYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [3 [3 (DIMETHYLAMINO)PROPYLSULFONYL]PROPYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [3 [3 (DIMETHYLAMINO)PROPYLSULFONYL]PROPYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [3 [3 (DIMETHYLAMINO)PROPYLTHIO]PROPYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [3 [3 (DIMETHYLAMINO)PROPYLTHIO]PROPYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [4 [3 (DIMETHYLAMINO)PROPYLSULFONYL]BUTYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [4 [3 (DIMETHYLAMINO)PROPYLSULFONYL]BUTYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [4 [3 (DIMETHYLAMINO)PROPYLTHIO]BUTYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [4 [3 (DIMETHYLAMINO)PROPYLTHIO]BUTYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [5 [3 (DIMETHYLAMINO)PROPYLSULFONYL]PENTYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [5 [3 (DIMETHYLAMINO)PROPYLSULFONYL]PENTYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [5 [3 (DIMETHYLAMINO)PROPYLTHIO]PENTYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [5 [3 (DIMETHYLAMINO)PROPYLTHIO]PENTYL]OXAZOL 2 YL]OCTAN 1 ONE; 1 [5 [6 [3 (DIMETHYLAMINO)PROPYLSULFONYL]HEXYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [6 [3 (DIMETHYLAMINO)PROPYLTHIO]HEXYL]OXAZOL 2 YL]DODECAN 1 ONE; 1 [5 [6 [3 (DIMETHYLAMINO)PROPYLTHIO]HEXYL]OXAZOL 2 YL]OCTAN 1 ONE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; N METHOXY N METHYLDODECANAMIDE; N METHOXY N METHYLOCTANAMIDE; N,N DIMETHYL 3 [2 (OXAZOL 5 YL)ETHYLTHIO]PROPAN 1 AMINE; N,N DIMETHYL 3 [3 (OXAZOL 5 YL)PROPYLTHIO]PROPAN 1 AMINE; N,N DIMETHYL 3 [4 (OXAZOL 5 YL)BUTYLTHIO]PROPAN 1 AMINE; N,N DIMETHYL 3 [5 (OXAZOL 5 YL)PENTYLTHIO]PROPAN 1 AMINE; N,N DIMETHYL 3 [6 (OXAZOL 5 YL)HEXYLTHIO]PROPAN 1 AMINE; OXAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HYDROPHILICITY; IC 50; MOLECULAR DOCKING; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANIMALS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; OXAZOLES; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; STATIC ELECTRICITY;

EID: 84855805087 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.11.027 Document Type: Article

Times cited : (14)

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