Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide

British Journal of Pharmacology

Volumn 133, Issue 8, 2001, Pages 1263-1275

  Jonsson, Kent Olov ^a   Vandevoorde, Séverine ^b   Lambert, Didier M ^b   Tiger, Gunnar ^a   Fowler, Christopher J ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Anandamide; Fatty acid amidohydrolase; Palmitoylethanolamide

Indexed keywords

AMIDASE; ANANDAMIDE; CANNABINOID 2 RECEPTOR; CARBON; FATTY ACID; KETONE; PALMIDROL; TRITIUM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CATALYSIS; CHO CELL; COMPETITIVE INHIBITION; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING;

EID: 0034864463     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704199     Document Type: Article

References (56)

1. 2 by bromoenol lactone and trifluoromethyl ketones
2. A proposed autacoid mechanism controlling mastocyte behaviour
3. Endocannabinoids control spasticity in a multiple sclerosis model
4. Functional role of high-affinity anandamide transport, as revealed by selective inhibition
5. The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
6. Biosynthesis, uptake, and degradation of anandamidc and palmitoylethanolamide in leukocytes
7. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase
8. Fatty acid amide hydrolase substrate specificity
9. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
10. Bidirectional control of airway responsiveness by endogenous cannabinoids
11. Control of pain initiation by endogenous cannabinoids
12. Effects of anandamide on cannabinoid receptors in rat brain membranes
13. The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity
14. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
15. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity
16. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
17. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
18. The cellular uptake of anandamide is coupled to its breakdown by fatty acid amide hydrolase (FAAH)
19. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor
20. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
21. The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters
22. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
23. Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship
24. Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase
25. Anandamide activates peripheral nociceptors in normal and arthritic knee joints
26. Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374)
27. Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404
28. Lowry protein assay containing sodium dodecyl sulfate in microtiter plates for protein determination on fractions from brain tissue
29. Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion
30. Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: Comparison with anandamide
31. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
32. Structure-activity relationships among N-arachidonoylethanolamine (anandamide) head group analogues for the anandamide transporter
33. Inhibitors of arachidonoyl ethanolamide hydrolysis
34. The palmitoylethanolamide and oleamide enigmas: Are these two fatty acid amides cannabimimetic?
35. 2 cannabinoid, as potential ligands for the cannabinoid receptors
36. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase
37. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
38. 9-tetrahydro-cannabinol or anandamide
39. Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'
40. N-(2-hydroxyethyl)hexadecamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation
41. Endocannabinoids
42. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): Vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors
43. Catabolism of N-acylethanolamine phospholipids by dog brain preparations
44. 14C] as a substrate for anandamide amidase
45. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide
46. Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations
47. The endocannabinoid system as a target for therapeutic drugs
48. 9-THC, WIN 55,212-2 and anandamide in mice
49. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells
50. 1 receptors
51. Characterization of cannabinoid receptors in the spleen and in mast cells
52. Anandamide induces apoptosis of PC-12 cells: Involvement of superoxide and caspase-3
53. Properties of rat liver N-acylethanolamine amidohydrolase
54. 2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells
55. 1 cannabinoid receptors
56. Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate