Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 2, 2012, Pages 949-961

  Ida, Yoshihiro ^a   Nemoto, Toru ^a   Hirayama, Shigeto ^a   Fujii, Hideaki ^a   Osa, Yumiko ^a   Imai, Masayuki ^b   Nakamura, Takashi ^b   Kanemasa, Toshiyuki ^b   Kato, Akira ^b   Nagase, Hiroshi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

Receptor; Analgesics; Naltrexone; Opioid

Indexed keywords

17 BENZYL 3 METHOXYMORPHINAN 6 ONE; 17 BENZYL 3 METHOXYMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 17 BENZYL 6,7 DIDEHYDRO 3 METHOXYQUINOLINO[2',3':6,7]MORPHINAN; 17 BENZYL 6,7 DIDEHYDROQUINOLINO[2',3':6,7]MORPHINAN 3 OL; 17 CYCLOBUTYLMETHYL 3 METHOXYMORPHINAN 6 ONE; 17 CYCLOBUTYLMETHYL 3 METHOXYMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 17 CYCLOBUTYLMETHYL 6,7 DIDEHYDRO 3 METHOXYQUINOLINO[2',3':6,7]MORPHINAN; 17 CYCLOPENTYLMETHYL 3 METHOXYMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 17 CYCLOPENTYLMETHYL 6,7 DIDEHYDRO 3 METHOXYQUINOLINO[2',3':6,7]MORPHINAN; 17 CYCLOPROPYLMETHYL 3 METHOXYMORPHINAN 6 ONE; 17 CYCLOPROPYLMETHYL 6,7 DIDEHYDRO 3 METHOXYQUINOLINO[2',3':6,7]MORPHINAN; 17 CYCLOPROPYLMETHYL 6,7 DIDEHYDROQUINOLINO[2',3':6,7]MORPHINAN 3 OL; 17 CYCLOPROPYLMETHYL 8,14 DEHYDRO 3 METHOXYMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 17 ISOBUTYL 3 METHOXYMORPHINAN 6 ONE; 3 METHOXY 17 (2,2,2 TRICHLOROETHOXYCARBONYL)MORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 3 METHOXY 17 METHYLMORPHINAN 6 ONE; 3 METHOXY 17 METHYLMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 3 METHOXY 17 PHENETHYLMORPHINAN 6 ONE; 3 METHOXY 17 PHENETHYLMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 3 METHOXYMORPHINAN 6 SPIRO 2' (1',3' DIOXOLANE); 6,7 DIDEHYDRO 17 ISOBUTYL 3 METHOXYQUINOLINO[2',3':6,7]MORPHINAN; 6,7 DIDEHYDRO 17 ISOBUTYL 3 METHOXYQUINOLINO[2',3':6,7]MORPHINAN 3 OL; 6,7 DIDEHYDRO 17 METHYLQUINOLINO[2',3':6,7]MORPHINAN 3 OL; 6,7 DIDEHYDRO 3 METHOXY 17 METHYLQUINOLINO[2',3':6,7]MORPHINAN; 6,7 DIDEHYDRO 3 METHOXY 17 PHENETHYLQUINOLINO[2',3':6,7]MORPHINAN; DELTA OPIATE RECEPTOR; MU OPIATE RECEPTOR; OPIATE AGONIST; QUINOLINOMORPHINAN 4 OL DERIVATIVE; SYK 259; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; CELL LINE; CELL MEMBRANE; GUINEA PIGS; HUMANS; MORPHINANS; PROTEIN BINDING; QUINOLINES; RATS; RECEPTORS, OPIOID, DELTA;

EID: 84855767878     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.047     Document Type: Article

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