Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole

Journal of Medicinal Chemistry

Volumn 42, Issue 9, 1999, Pages 1673-1679

  Coop, Andrew ^a,d   Rothman, Richard B ^b   Dersch, Christina ^b   Partilla, John ^b   Porreca, Frank ^c   Davis, Peg ^c   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NIDA Addiction Research Center   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 CYCLOPROPYLMETHYL 6,7 DIDEHYDRO 4 HYDROXY 3 METHOXY 6,7:2',3' INDOLOMORPHINAN; 4 HYDROXY 3 METHOXYINDOLOMORPHINAN DERIVATIVE; CODEINE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NALTRINDOLE; OXYCODONE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; 17 CYCLOPROPYLMETHYL 6,7 DIDEHYDRO 4 HYDROXY 3 METHOXY 6,7 2',3' INDOLOMORPHINAN; 17-CYCLOPROPYLMETHYL-6,7-DIDEHYDRO-4-HYDROXY-3-METHOXY-6,7-2',3'-INDOLOMORPHINAN; DRUG DERIVATIVE; INDOLE DERIVATIVE; LIGAND; NALTREXONE; NARCOTIC ANTAGONIST;

ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; ILEUM; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; VAS DEFERENS; ANIMAL; BINDING COMPETITION; BRAIN; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE; MUSCLE CONTRACTION; PHYSIOLOGY; RABBIT; SMOOTH MUSCLE; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; BRAIN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); ILEUM; INDOLES; LIGANDS; MALE; MICE; MICE, INBRED ICR; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NALTREXONE; NARCOTIC ANTAGONISTS; RABBITS; RECEPTORS, OPIOID, DELTA; VAS DEFERENS;

EID: 0033528829     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9807003     Document Type: Article

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