Drug design and synthesis of ε opioid receptor agonist: 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6, 14-endoethenomorphinan-7α-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative ε opioid receptor

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 15, 2004, Pages 4133-4145

  Fujii, Hideaki ^a   Narita, Minoru ^b,c   Mizoguchi, Hirokazu ^b,d   Murachi, Miho ^a   Tanaka, Toshiaki ^a   Kawai, Koji ^a   Tseng, Leon F ^b   Nagase, Hiroshi ^a,e  

^a TORAY INDUSTRIES INC   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c HOSHI UNIVERSITY   (Japan)

^d TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^e KITASATO UNIVERSITY   (Japan)

Author keywords

Analgesics; Message address concept; Putative opioid receptor; TAN 821

Indexed keywords

17 (CYCLOPROPYLMETHYL) 4,5ALPHA EPOXY 3,6BETA DIHYDROXY 6,14 ENDOETHENOMORPHINAN 7ALPHA (N METHYL N PHENETHYL)CARBOXAMIDE; BETA ENDORPHIN[1-27]; DELTA OPIATE RECEPTOR ANTAGONIST; EPSILON OPIATE RECEPTOR; EPSILON OPIATE RECEPTOR AGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DERIVATIVE; KAPPA OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR ANTAGONIST; TAN 821; UNCLASSIFIED DRUG;

AGONIST; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; HOT PLATE TEST; IC 50; MALE; MEDULLA OBLONGATA; MEMBRANE; NONHUMAN; PONS; RAT; STIMULATION; TAIL FLICK TEST; VAS DEFERENS;

ACETAMIDES; ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MICE; MICE, INBRED ICR; MOLECULAR CONFORMATION; MORPHINANS; MUSCLE, SMOOTH; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; TIME FACTORS;

EID: 3042752494     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.05.024     Document Type: Article

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