Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6302-6305

  Nagase, Hiroshi ^a   Nemoto, Toru ^a   Matsubara, Ayaka ^a   Saito, Manabu ^a   Yamamoto, Naoshi ^a   Osa, Yumiko ^a   Hirayama, Shigeto ^a   Nakajima, Mayumi ^b   Nakao, Kaoru ^b   Mochizuki, Hidenori ^b   Fujii, Hideaki ^a  

^a KITASATO UNIVERSITY   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

Author keywords

Receptor; Analgesics; Naltrexone; Opioid

Indexed keywords

1,2,3,4,4A,5,12,12AALPHA OCTAHYDRO 4AALPHA (3 HYDROXYPHENYL) 2 METHYLQUINOLINO[2,3 G]ISOQUINOLINE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; DELTA OPIATE RECEPTOR AGONIST; KNT 127; SN 28; SYK 14; SYK 3; SYK 33; SYK 4; SYK 58; SYK 69; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; DRUG BINDING SITE; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACETIC ACID; ANALGESICS, OPIOID; ANIMALS; BENZAMIDES; BLOOD-BRAIN BARRIER; INDICATORS AND REAGENTS; INJECTIONS, SPINAL; INJECTIONS, SUBCUTANEOUS; MICE; MORPHINANS; PAIN MEASUREMENT; PIPERAZINES; QUINOLINES; RECEPTORS, OPIOID, DELTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957868723     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.083     Document Type: Article

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