Vitamin E dose-response studies in humans with use of deuterated RRR- α-tocopherol

American Journal of Clinical Nutrition

Volumn 68, Issue 4, 1998, Pages 847-853

  Traber, Maret G ^a   Rader, Daniel ^b   Acuff, Robert V ^b   Ramakrishnan, Rajasekhar ^b   Brewer, H Bryan ^b   Kayden, Herbert J ^b  

^a OREGON STATE UNIVERSITY   (United States)

^b NONE

Author keywords

Absorption; Adults; Chylomicrons; Humans; Lipoproteins; Stable isotopes; Vitamin E supplements; tocopherol transfer protein

Indexed keywords

ALPHA TOCOPHEROL; CARRIER PROTEIN; CHYLOMICRON; LIPOPROTEIN;

ADULT; ALPHA TOCOPHEROL DEFICIENCY; ARTICLE; CHROMOSOME 8; DIET SUPPLEMENTATION; DISEASE PREDISPOSITION; DOSE RESPONSE; FEMALE; GAS CHROMATOGRAPHY; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; RETINITIS PIGMENTOSA;

EID: 0031709172     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/68.4.847     Document Type: Article

References (52)

1. Dimitrov NV, Meyer C, Gilliland D, Ruppenthal M, Chenoweth W, Malone W. Plasma tocopherol concentrations in response to supplemental vitamin E. Am J Clin Nutr 1991;53:723-9.
2. Reaven PD, Witztum JL. Comparison of supplementation of RRR-α-tocopherol and racemic α-tocopherol in humans. Effects on lipid levels and lipoprotein susceptibility to oxidation. Arterioscler Thromb 1993;13:601-8.
3. Princen HMG, van Poppel G, Vogelezang C, Buytenhek R, Kok FJ. Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking. Arterioscler Thromb 1992;12:554-62.
4. Princen HMG, van Duyvenvoorde W, Buytenhek R, et al. Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler Thromb Vasc Biol 1995;15:325-33.
5. Jialal I, Fuller CJ, Huet BA. The effect of α-tocopherol supplementation on LDL oxidation. A dose-response study. Arterioscler Thromb Vasc Biol 1995;15:190-8.
6. Sokol RJ, Heubi JE, Iannaccone S, Bove KE, Harris RE, Balistreri WF. The mechanism causing vitamin E deficiency during chronic childhood cholestasis. Gastroenterology 1983;85:1172-82.
7. Stumpf DA, Sokol R, Bettis D, et al. Friedreich's disease. V. Variant form with vitamin E deficiency and normal fat absorption. Neurology 1987;37:68-74.
8. Traber MG, Kayden HJ, Green JB, Green MH. Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats. Am J Clin Nutr 1986;44:914-23.
9. MacMahon MT, Neale G. The absorption of α-tocopherol in control subjects and in patients with intestinal malabsorption. Clin Sci 1970;38:197-210.
10. Kelleher J, Losowsky MS. The absorption of α-tocopherol in man. Br J Nutr 1970;24:1033-47.
11. Blomstrand R, Forsgren L. Labelled tocopherols in man. Int J Vitam Nutr Res 1968;38:328-44.
12. Cheesemen KH, Holley AE, Kelly FJ, Wasil M, Hughes L, Burton G. Biokinetics in humans of RRR-α-tocopherol: the free phenol, acetate ester, and succinate ester forms of vitamin E. Free Radic Biol Med 1995;19:591-8.
13. Traber MG, Burton GW, Ingold KU, Kayden HJ. RRR- and SRR-α-tocopherols are secreted without discrimination in human chylomicrons, but RRR-α-tocopherol is preferentially secreted in very low density lipoproteins. J Lipid Res 1990;31:675-85.
14. Traber MG, Burton GW, Hughes L, et al. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J Lipid Res 1992;33:1171-82.
15. Massey JB. Kinetics of transfer of α-tocopherol between model and native plasma lipoproteins. Biochim Biophys Acta 1984;793: 387-92.
16. Granot E, Tamir I, Deckelbaum RJ. Neutral lipid transfer protein does not regulate α-tocopherol transfer between human plasma lipoproteins. Lipids 1988;23:17-21.
17. Traber MG, Lane JC, Lagmay N, Kayden HJ. Studies on the transfer of tocopherol between lipoproteins. Lipids 1992;27:657-63.
18. Kostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, Dieplinger H. Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells. Biochem J 1995;305:659-67.
19. Traber MG, Olivecrona T, Kayden HJ. Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. J Clin Invest 1985;75:1729-34.
20. Traber MG, Rudel LL, Burton GW, Hughes L, Ingold KU, Kayden HJ. Nascent VLDL from liver perfusions of cynomolgus monkeys are preferentially enriched in RRR-compared with SRR-α tocopherol: studies using deuterated tocopherols. J Lipid Res 1990; 31:687-94.
21. Traber MG. Determinants of plasma vitamin E concentrations. Free Radic Biol Med 1994;16:229-39.
22. Sato Y, Hagiwara K, Arai H, Inoue K. Purification and characterization of the α-tocopherol transfer protein from rat liver. FEBS Lett 1991;288:41-5.
23. Yoshida H, Yusin M, Ren I, et al. Identification, purification and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. J Lipid Res 1992;33:343-50.
24. Kuhlenkamp J, Ronk M, Yusin M, Stolz A, Kaplowitz N. Identification and purification of a human liver cytosolic tocopherol binding protein. Protein Expr Purif 1993;4:382-9.
25. Arita M, Sato Y, Miyata A, et al. Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Biochem J 1995;306:437-43.
26. Traber MG, Sokol RJ, Burton GW, et al. Impaired ability of patients with familial isolated vitamin E deficiency to incorporate α-tocopherol into lipoproteins secreted by the liver. J Clin Invest 1990;85:397-407.
27. Traber MG, Sokol RJ, Kohlschütter A, et al. Impaired discrimination between stereoisomers of α-tocopherol in patients with familial isolated vitamin E deficiency. J Lipid Res 1993;34:201-10.
28. Ben Hamida M, Belal S, Sirugo G, et al. Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families. Neurology 1993;43:2179-83.
29. Ben Hamida C, Doerflinger N, Belal S, et al. Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Nat Genet 1993;5: 195-200.
30. Yokota T, Shiojiri T, Gotoda T, Arai H. Retinitis pigmentosa and ataxia caused by a mutation in the gene for the α-tocopherol-transfer protein. N Engl J Med 1996;335:1769-70.
31. Ouahchi K, Arita M, Kayden H, et al. Ataxia with isolated vitamin E deficiency is caused by mutations in the α-tocopherol transfer protein. Nat Genet 1995;9:141-5.
32. Hentati A, Deng H-X, Hung W-Y, et al. Gene structure and mutations in familial vitamin E deficiency. Ann Neurol 1996;39: 295-300.
33. Hosomi A, Arita M, Sato Y, et al. Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 1997;409:105-8.
34. Ingold KU, Burton GW, Foster DO, Hughes L, Lindsay DA, Webb A. Biokinetics of and discrimination between dietary RRR- and SRR-α-tocopherols in the male rat. Lipids 1987;22:163-72.
35. Ingold KU, Hughes L, Slaby M, Burton GW. Synthesis of 2R,4′R,8′R-α-tocopherols selectively labelled with deuterium. J Labelled Comp Radiopharm 1987;24:817-31.
36. Traber MG, Ingold KU, Burton GW, Kayden HJ. Absorption and transport of deuterium-substituted 2R,4′R,8′R-α-tocopherol in human lipoproteins. Lipids 1988;23:791-7.
37. Burton GW, Ingold KU, Foster DO, et al. Comparison of free α-tocopherol and α-tocopheryl acetate as sources of vitamin E in rats and humans. Lipids 1988;23:834-40.
38. Acuff RV, Thedford SS, Hidiroglou NN, Papas AM, Odom TA Jr. Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds. Am J Clin Nutr 1994;60:397-402.
39. Schultz M, Leist M, Petrzika M, Gassmann B, Brigelius-Flohé R. Novel urinary metabolite of α-tocopherol, 2,5,7,8-tetramethyl-2(2′carboxyethyl)-6-hydroxychroman as an indicator of an adequate vitamin E supply? Am J Clin Nutr 1995;62(suppl): 1527S-34S.
40. Traber MG, Ramakrishnan R, Kayden HJ. Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-α-tocopherol. Proc Natl Acad Sci U S A 1994;91:10005-8.
41. National Research Council. Recommended dietary allowances. 10th ed. Washington, DC: National Academy of Sciences Press, 1989.
42. Cohn W, Loechleiter F, Weber F. α-Tocopherol is secreted from rat liver in very low density lipoproteins. J Lipid Res 1988;29: 1359-66.
43. Hamilton RL, Moorehouse A, Havel RJ. Isolation and properties of nascent lipoproteins from highly purified rat hepatocytic Golgi fractions. J Lipid Res 1991;32:529-43.
44. Forte TM, Goth-Goldstein R, Nordhausen RW, McCall MR. Apolipoprotein A-I-cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles. J Lipid Res 1993;34:317-24.
45. Traber MG, Kayden HJ. Preferential incorporation of α-tocopherol vs γ-tocopherol in human lipoproteins. Am J Clin Nutr 1989; 49:517-26.
46. Arita M, Nomura K, Arai H, Inoue K. α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Proc Natl Acad Sci U S A 1997;94:12437-41.
47. Burton GW, Traber MG, Acuff RV, et al. Human plasma and tissue α-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr 1998;67:669-84.
48. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-6.
49. Stampfer MJ, Hennekens C, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and risk of coronary disease in women. N Engl J Med 1993;328:1444-9.
50. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease - Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347:781-6.
51. Rapola JM, Virtamo J, Ripatti S, et al. Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 1997;349:1715-20.
52. Heinonen OP, Albanes D, Virtamo J, et al. Prostate cancer and supplementation with α-tocopherol and β-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 1998;90:440-6.