Biodiscrimination of α-tocopherol stereoisomers in humans after oral administration

American Journal of Clinical Nutrition

Volumn 65, Issue 3, 1997, Pages 785-789

  Kiyose, Chikako ^a   Muramatsu, Riho ^b   Kameyama, Yoshiko ^b   Ueda, Tadahiko ^b   Igarashi, Osamu ^b  

^a OCHANOMIZU UNIVERSITY   (Japan)

^b NONE

Author keywords

all rac tocopherol; bioavailability; biodiscrimination; lipoprotein; RRR tocopherol; tocopherol stereoisomers

Indexed keywords

ALPHA TOCOPHEROL; HIGH DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG DISCRIMINATION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LIPOPROTEIN BLOOD LEVEL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; STEREOISOMERISM; VITAMIN DEFICIENCY; VITAMIN METABOLISM;

EID: 0031039880     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/65.3.785     Document Type: Article

References (17)

1. Weiser H, Vecchi M. Stereoisomers of α-tocopheryl acetate H. Biopotencies of all eight stereoisomers, individually or in mixtures, as determined by rat resorption-gestation test. Int J Vitam Nutr Res 1982;52:351-70.
2. Traber MG, Ingold KU, Burtion GW, Kayden HJ. Absorption and transport of deuterium-substituted 2R,4′R,8′R-α-tocopherol in human lipoproteins. Lipids 1988;23:791-7.
3. Ingold KU, Burton GW, Foster DO, Hughes L, Lindsay DA, Webb A. Biokinetics of and discrimination between dietary RRR- and SRR-α-tocopherols in the male rat. Lipids 1987;22:163-72.
4. Peake IR, Windmueller HG, Bieri JG. A comparison of the intestinal absorption, lymph and plasma transport, and tissue uptake of α- and γ-tocopherols in the rat. Biochim Biophys Acta 1972;260:679-88.
5. Hatam LJ, Kayden HJ. The failure of α-tocopherol supplementation to alter the distribution of lipoprotein cholesterol in normal and hyperlipoproteinemic persons. Am J Clin Pathol 1981;76:122-4.
6. Acuff RV, Thedford SS, Hidiroglou NN, Papas AM, Odom TA Jr. Relative bioavailability of RRR- und all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds. Am J Clin Nutr 1994;60:397-402.
7. Ueda T, Ichikawa H, Igarashi O. Determination of α-tocopherol stereoisomers in biological specimens using chiral phase high-performance liquid chromatography. J Nutr Sci Vitaminol 1993;39: 207-19.
8. Nitta C, Hayashi K, Ueda T, Igarashi O. Distribution of α-tocopherol stereoisomers in rats. Biosci Biotechnol Biochem 1993;57: 1406-7.
9. Nitta-Kiyose C, Hayashi K, Ueda T, Igarashi O. Distribution of α-tocopherol stereoisomers in rats. Biosci Biotechnol Biochem 1994;58: 2000-3.
10. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-53.
11. Acuff RV, Ferslew KE, Daigneault EA, Orcutt RH, Thedford SS, Stanton PE. Pharmacokinetic modeling and bioavailability of RRR and all-racemic α-tocopherol acetate in human blood components. Ann N Y Acad Sci 1989;507:406-8.
12. Ferslew KE, Acuff RV, Daigneault EA, Woolley TW, Stanton PE Jr. Pharmacokinetics and bioavailability of the RRR and all-racemic stereoisomers of α-tocopherol in humans after single oral administration. J Clin Pharmacol 1993;33:84-8.
13. Traber MG, Burton GW, Ingold KU, Kayden HJ. RRR- and SRR-α-tocopherols are secreted without discrimination in human chylomicrons, but RRR-α-tocopherol is preferentially secreted in very low density lipoproteins. J Lipid Res 1990;31:675-85.
14. Traber MG, Sokol RJ, Kohlschutter A, et al. Impaired discrimination between stereoisomers of α-tocopherol in patients with familial isolated vitamin E deficiency. J Lipid Res 1993;34:201-10.
15. Sato Y, Hagiwara K, Arai H, Inoue K. Purification and characterization of the α-tocopheroI transfer protein from rat liver. FEBS Lett 1991;288:41-5.
16. Arita M, Sato Y, Miyata A, et al. Human α-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Biochem J 1995;306:437-43.
17. Ogihara T, Miki M, Kitagawa M, Mino M. Distribution of tocopherol among human plasma lipoproteins. Clin Chim Acta 1988;174: 299-306.