Daily supplementation of tocotrienol-rich fraction or α-tocopherol did not induce immunomodulatory changes in healthy human volunteers

British Journal of Nutrition

Volumn 101, Issue 6, 2009, Pages 810-815

  Radhakrishnan, Ammu K ^a   Lee, Ai Ling ^a   Wong, Pak Fong ^a   Kaur, Jagmohni ^a   Aung, Htin ^a   Nesaretnam, Kalanithi ^b  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b Persiaran Institusi ^*  (Malaysia)

Author keywords

Tocopherol; Cytokines; Immune system; Tocotrienol rich fraction; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 4; NATURAL VITAMIN E; PALM OIL; PLACEBO; TOCOTRIENOL RICH FRACTION; TOCOVID SUPRABIO; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL ISOLATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; NORMAL HUMAN; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SHORT COURSE THERAPY; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADULT; ALPHA-TOCOPHEROL; ANALYSIS OF VARIANCE; CONCANAVALIN A; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-4; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; MITOGENS; PLANT OILS; TOCOTRIENOLS; TREATMENT FAILURE; VITAMIN E; YOUNG ADULT;

EID: 67649435588     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508039998     Document Type: Article

References (30)

1. Ong ASH (1992) Natural sources of tocotrienols. In Vitamin E in Health and Disease, pp. 3-8 [L Packer and J Fuchs, editors]. New York, NY: Marcel Dekker.
2. Hughes DA (1999) Effects of dietary antioxidants on the immune function of middle-aged adults. Proc Nutr Soc 58, 79-84.
3. Macdonald J, Galley HF & Webster NR (2003) Oxidative stress and gene expression in sepsis. Br J Anaesth 90, 221-232.
4. Packer L, Weber SU & Rimbach G (2001) Molecular aspects of α-tocotrienol antioxidant action and cell signalling. J Nutr 131, 369S-373S.
5. Constantinescu A, Han D & Packer L (1993) Vitamin E recycling in human erythrocyte membranes. J Biol Chem 268, 10906-10913.
6. Das N, Chowdhury TD, Chattopadhyay A & Datta AG (2004) Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Pol J Pharm 56, 85-96.
7. Yap SP, Yean KH & Wong JW (2001) Pharmacokinetics and bioavailability of α, γ- and δ-tocotrienols under different food status. J Pharm Pharmacol 53, 67-71.
8. Prasad KN, Kumar B, Yan XD, Hanson AJ & Cole WC (2003) α-Tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: A review. J Am Coll Nutr 22, 108-117.
9. Gao X, Wilde PE, Lichtenstein AH, Bermudez OI & Tucker KL (2006) The maximal amount of dietary α-tocopherol intake in U.S. adults (NHANES 2001-2002). J Nutr 136, 1021-1026.
10. Yoshida Y, Niki E & Noguchi N (2003) Comparative study on the action of tocopherols and tocotrienols as antioxidant: Chemical and physical effects. Chem Phys Lipids 123, 63-75.
11. Nesaretnam K, Radhakrishnan A, Selvaduray KR, Reimann K, Pailoor J, Razak G, Mahmood MM & Dahliwal JS (2002) Effect of palm oil carotene on breast cancer tumorigenicity in nude mice. Lipids 37, 557-560.
12. Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, Morrow FD, Rocklin R & Blumberg JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 52, 557-563.
13. Carroll KK, Guthrie N, Nesaretnam K, Gapor AB & Chambers AF (1995) Anti-cancer properties of tocotrienols from palm oil. In Nutrition, Lipids, Health and Disease, pp. 117-121 [ASH Ong, E Niki and L Packer, editors]. Champaign, IL: AOCS Press.
14. Nesaretnam K, Stephen R, Dils R & Darbre P (1998) Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33, 461-469.
15. McIntyre BS, Briski KP, Gapor A & Sylvester PW (2004) Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med 2224, 292-301.
16. Gu JY, Wakizono Y, Sunada Y, Hung P, Nonaka M, Sugano M & Yamada K (1999) Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in Brown Norway rats. Biosci Biotechnol Biochem 63, 1697-1702.
17. Nesaretnam K, Ambra R, Selvaduray KR, Radhakrishnan A, Reimann K, Razak G & Virgili F (2004) Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39, 459-467.
18. Del Rio M, Ruedas G, Medina S, Victor VM & De la Fuente M (1998) Improvement by several antioxidants of macrophage functions in vitro. Life Sci 63, 871-881.
19. Favier A, Sappey C, Leclerc P, Faure P & Micoud M (1994) Antioxidant status and lipid peroxidation in patients infected with HIV. Chem Biol Interact 91, 165-180.
20. Penn ND, Purkins L, Kelleher J, Heatley RV, Mascie-Taylor BH & Belfield PW (1991) The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: A randomized controlled trial. Age Ageing 20, 169-174.
21. Lee CYJ & Wan JMF (2000) Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women. J Nutr 130, 2932-2937.
22. Jiang W, Kang L, Lu H-Z, Pan X, Lin Q, Pan Q, Xue Y, Weng X & Tang Y-W (2004) Normal values for CD4 and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai. Clin Diag Lab Immunol 11, 811-813.
23. Al Qouzi A, Al Salamah A, Al Rasheed R, Al Musalam A, Al Khairy K, Kheir O, Al Ajaji S & Hajeer AH (2002) Immunophenotyping of peripheral blood lymphocytes in Saudi men. Clin Diag Lab Immunol 9, 279-281.
24. Prince HE, Hirji K, Waldbeser LS, Plaeger-Marshall S, Kleinman S & Lanier L (1985) Influence of racial background on the distribution of T-cell subsets and leu-11 positive lymphocytes in healthy blood donors. Diag Immunol 3, 33-37.
25. Loft S, Vistisen K, Ewertz M, Thonneland A, Overvad K & Poulsen HE (1992) Oxidative DNA-damage estimated by 8-hydroxydeoxyguanosine excretion in man: Influence of smoking, gender and body mass index. Carcinogenesis 13, 2241-2247.
26. Mustad VA, Smith CA, Ruey PP, Edens NK & DeMichele SJ (2002) Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. Am J Clin Nutr 76, 1237-1243.
27. Nesaretnam K, Ambra R, Selvaduray KR, Radhakrishnan A, Canali R & Virgili F (2004) Tocotrienol-rich fraction from palm oil and gene expression in human breast cancer cells. Ann N Y Acad Sci 1031 143-157.
28. Mensink RP, van Houwelingen AC, Kromhout D & Hornstra G (1999) A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 69, 213-219.
29. Mustad VA, Smith CA, Ruey PP, Edens NK & DeMichele SJ (2002) Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. Am J Clin Nutr 76, 1237-1243.
30. Masaaki O, Mariko O, Ikeda I, Tachibana H & Yamada K (2002) Tocotrienol levels in various tissues of Sprague-Dawley rats after intragastric administration of tocotrienols. Biosci Biotechnol Biochem 66 1768-1771.