Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling

Frontiers in Cellular Neuroscience

Volumn 3, Issue OCT, 2009, Pages

  Fenech, Claire ^a   Patrikainen, Lila ^a   Kerr, Daniel S ^b   Grall, Sylvie ^a   Liu, Zhenhui ^a   Laugerette, Fabienne ^a   Malnic, Bettina ^b   Montmayeur, Jean Pierre ^a  

^a CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bitter; G protein coupled receptor; Guanine nucleotide exchange factors; Gustducin; Regulators of G protein signaling; Ric 8A; Ric 8B; Taste

Indexed keywords

EID: 84855734331     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/neuro.03.011.2009     Document Type: Article

References (46)

1. Adler, E., Hoon, M. A., Mueller, K. L., Chandrashekar, J., Ryba, N. J., and Zuker, C. S. (2000). A novel family of mammalian taste receptors. Cell 100, 693-702.
2. Avenet, P., Hofmann, F., and Lindemann, B. (1988). Transduction in taste receptor cells requires cAMPdependent protein kinase. Nature 331, 351-354.
3. Bernard, M. L., Peterson, Y. K., Chung, P., Jourdan, J., and Lanier, S. M. (2001). Selective interaction of AGS3 with G-proteins and the influence of AGS3 on the activation state of G-proteins. J. Biol. Chem. 276, 1585-1593.
4. Chandrashekar, J., Hoon, M. A., Ryba, N. J., and Zuker, C. S. (2006). The receptors and cells for mammalian taste. Nature 444, 288-294.
5. Chandrashekar, J., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., and Ryba, N. J. (2000). T2Rs function as bitter taste receptors. Cell 100, 703-711.
6. Clapp, T. R., Stone, L. M., Margolskee, R. F., and Kinnamon, S. C. (2001). Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci. 2, 6.
7. DeFazio, R. A., Dvoryanchikov, G., Maruyama, Y., Kim, J. W., Pereira, E., Roper, S. D., and Chaudhari, N. (2006). Separate populations of receptor cells and presynaptic cells in mouse taste buds. J. Neurosci. 26, 3971-3980.
8. Durocher, Y., Perret, S., Thibaudeau, E., Gaumond, M. H., Kamen, A., Stocco, R., and Abramovitz, M. (2000). A reporter gene assay for highthroughput screening of G-proteincoupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture. Anal. Biochem. 284, 316-326.
9. He, W., Yasumatsu, K., Varadarajan, V., Yamada, A., Lem, J., Ninomiya, Y., Margolskee, R. F., and Damak, S. (2004). Umami taste responses are mediated by alpha-transducin and alpha-gustducin. J. Neurosci. 24, 7674-7680.
10. Hoon, M. A., Adler, E., Lindemeier, J., Battey, J. F., Ryba, N. J., and Zuker, C. S. (1999). Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96, 541-551.
11. Huang, L., Shanker, Y. G., Dubauskaite, J., Zheng, J. Z., Yan, W., Rosenzweig, S., Spielman, A. I., Max, M., and Margolskee, R. F. (1999). Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat. Neurosci. 2, 1055-1062.
12. Jean-Baptiste, G., Yang, Z., and Greenwood, M. T. (2006). Regulatory mechanisms involved in modulating RGS function. Cell. Mol. Life Sci. 63, 1969-1985.
13. Kerr, D. S., Von Dannecker, L. E., Davalos, M., Michaloski, J. S., and Malnic, B. (2008). Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons. Mol. Cell. Neurosci. 38, 341-348.
14. Klattenhoff, C., Montecino, M., Soto, X., Guzman, L., Romo, X., Garcia, M. A., Mellstrom, B., Naranjo, J. R., Hinrichs, M. V., and Olate, J. (2003). Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. J. Cell Physiol. 195, 151-157.
15. Kusakabe, Y., Yamaguchi, E., Tanemura, K., Kameyama, K., Chiba, N., Arai, S., Emori, Y., and Abe, K. (1998). Identification of two alpha-subunit species of GTP-binding proteins, Galpha15 and Galphaq, expressed in rat taste buds. Biochim. Biophys. Acta 1403, 265-272.
16. Kusakabe, Y., Yasuoka, A., Asano-Miyoshi, M., Iwabuchi, K., Matsumoto, I., Arai, S., Emori, Y., and Abe, K. (2000). Comprehensive study on G protein alpha-subunits in taste bud cells, with special reference to the occurrence of Galphai2 as a major Galpha species. Chem. Senses 25, 525-531.
17. Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., and Adler, E. (2002). Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U.S.A. 99, 4692-4696.
18. Matsunami, H., Montmayeur, J. P., and Buck, L. B. (2000). A family of candidate taste receptors in human and mouse. Nature 404, 601-604.
19. McLaughlin, S. K., McKinnon, P. J., and Margolskee, R. F. (1992). Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357, 563-569.
20. Neitzel, K. L., and Hepler, J. R. (2006). Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling. Semin. Cell Dev. Biol. 17, 383-389.
21. Nelson, G., Chandrashekar, J., Hoon, M. A., Feng, L., Zhao, G., Ryba, N. J., and Zuker, C. S. (2002). An amino-acid taste receptor. Nature 416, 199-202.
22. Nelson, G., Hoon, M. A., Chandrashekar, J., Zhang, Y., Ryba, N. J., and Zuker, C. S. (2001). Mammalian sweet taste receptors. Cell 106, 381-390.
23. Nishiguchi, K. M., Sandberg, M. A., Kooijman, A. C., Martemyanov, K. A., Pott, J. W., Hagstrom, S. A., Arshavsky, V. Y., Berson, E. L., and Dryja, T. P. (2004). Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. Nature 427, 75-78.
24. Nishimura, A., Okamoto, M., Sugawara, Y., Mizuno, N., Yamauchi, J., and Itoh, H. (2006). Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G proteincoupled receptor in intact cells. Genes Cells 11, 487-498.
25. Oldham, W. M., and Hamm, H. E. (2008). Heterotrimeric G protein activation by G-protein-coupled receptors. Nat. Rev. Mol. Cell Biol. 9, 60-71.
26. Ozeck, M., Brust, P., Xu, H., and Servant, G. (2004). Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur. J. Pharmacol. 489, 139-149.
27. Pfaffl, M. W. (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45.
28. Pfaffl, M. W., Horgan, G. W., and Dempfle, L. (2002). Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30, e36.
29. Rossier, O., Cao, J., Huque, T., Spielman, A. I., Feldman, R. S., Medrano, J. F., Brand, J. G., and le Coutre, J. (2004). Analysis of a human fungiform papillae cDNA library and identification of taste-related genes. Chem. Senses 29, 13-23.
30. Sainz, E., Cavenagh, M. M., Gutierrez, J., Battey, J. F., Northup, J. K., and Sullivan, S. L. (2007a). Functional characterization of human bitter taste receptors. Biochem. J. 403, 537-543.
31. Sainz, E., Cavenagh, M. M., LopezJimenez, N. D., Gutierrez, J. C., Battey, J. F., Northup, J. K., and Sullivan, S. L. (2007b). The G-protein coupling properties of the human sweet and amino acid taste receptors. Dev. Neurobiol. 67, 948-959.
32. Shindo, Y., Miura, H., Carninci, P., Kawai, J., Hayashizaki, Y., Ninomiya, Y., Hino, A., Kanda, T., and Kusakabe, Y. (2008). G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue. Biochem. Biophys. Res. Commun. 376, 504-508.
33. Siderovski, D. P., and Willard, F. S. (2005). The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int. J. Biol. Sci. 1, 51-66.
34. Sinnarajah, S., Dessauer, C. W., Srikumar, D., Chen, J., Yuen, J., Yilma, S., Dennis, J. C., Morrison, E. E., Vodyanoy, V., and Kehrl, J. H. (2001). RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature 409, 1051-1055.
35. Tall, G. G., and Gilman, A. G. (2005). Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/ Galphai-GDP complexes. Proc. Natl. Acad. Sci. U.S.A. 102, 16584-16589.
36. Tall, G. G., Krumins, A. M., and Gilman, A. G. (2003). Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. J. Biol. Chem. 278, 8356-8362.
37. Thomas, C. J., Tall, G. G., Adhikari, A., and Sprang, S. R. (2008). Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3. J. Biol. Chem. 283, 23150-23160.
38. Tizzano, M., Dvoryanchikov, G., Barrows, J. K., Kim, S., Chaudhari, N., and Finger, T. E. (2008). Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue. BMC Neurosci. 9, 110.
39. Tonosaki, K., and Funakoshi, M. (1988). Cyclic nucleotides may mediate taste transduction. Nature 331, 354-356.
40. Ueda, T., Ugawa, S., Yamamura, H., Imaizumi, Y., and Shimada, S. (2003). Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. J. Neurosci. 23, 7376-7380.
41. von Buchholtz, L., Elischer, A., Tareilus, E., Gouka, R., Kaiser, C., Breer, H., and Conzelmann, S. (2004). RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. Eur. J. Neurosci. 19, 1535-1544.
42. Von Dannecker, L. E., Mercadante, A. F., and Malnic, B. (2005). Ric-8B, an olfactory putative GTP exchange factor, amplifies signal transduction through the olfactory-specific G-protein Galphaolf. J. Neurosci. 25, 3793-3800.
43. Von Dannecker, L. E., Mercadante, A. F., and Malnic, B. (2006). Ric-8B promotes functional expression of odorant receptors. Proc. Natl. Acad. Sci. U.S.A. 103, 9310-9314.
44. Wilkie, T. M., and Kinch, L. (2005). New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart. Curr. Biol. 15, R843-R854.
45. Wong, G. T., Gannon, K. S., and Margolskee, R. F. (1996). Transduction of bitter and sweet taste by gustducin. Nature 381, 796-800.
46. Zhao, G. Q., Zhang, Y., Hoon, M. A., Chandrashekar, J., Erlenbach, I., Ryba, N. J., and Zuker, C. S. (2003). The receptors for mammalian sweet and umami taste. Cell 115, 255-266.