Ric-8B, an olfactory putative GTP exchange factor, amplifies signal transduction through the olfactory-specific G-protein gαolf

Journal of Neuroscience

Volumn 25, Issue 15, 2005, Pages 3793-3800

  Von Dannecker, Luiz Eduardo C ^a   Mercadante, Adriana F ^a   Malnic, Bettina ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

G protein; G protein coupled receptors; GEF; Odorant receptors; Olfactory neurons; Signal transduction; Synembryn

Indexed keywords

CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; OLFACTORY SPECIFIC G PROTEIN; PROTEIN; PROTEIN RIC 8B; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL LEVEL; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY RECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; CELL LINE; CYCLIC AMP; ENZYME ACTIVATION; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MUTAGENESIS; NUCLEAR PROTEINS; OLFACTORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES; YEASTS;

EID: 17644404436     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4595-04.2005     Document Type: Article

References (50)

1. Belluscio L, Gold GH, Nemes A, Axel R (1998) Mice deficient in G(olf) are anosmic. Neuron 20:69-81.
2. Berghard A, Buck LB, Liman ER (1996) Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs. Proc Natl Acad Sci USA 93:2365-2369.
3. Boekhoff I, Breer H (1992) Termination of second messenger signaling in olfaction. Proc Natl Acad Sci USA 89:471-474.
4. Boekhoff I, Tareilus E, Strotmann J, Breer H (1990) Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J 9:2453-2458.
5. Borisy F, Ronnet G, Cunningham A, Juilfs D, Beavo J, Snyder S (1992) Calcium/calmodulin-activated phosphodiasterase expressed in olfactory receptor neurons. J Neurosci 12:915-923.
6. Breer H, Boekhoff I, Tareilus E (1990) Rapid kinetics of second messenger formation in olfactory transduction. Nature 345:65-68.
7. Brunet LJ, Gold GH, Ngai J (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17:681-693.
8. Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175-187.
9. Buck LB (2000) The molecular architecture of odor and pheromone sensing in mammals. Cell 100:611-618.
10. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature 368:545-548.
11. Cismowski MJ, Takesono A, Ma C, Lizano JS, Xie X, Fuernkranz H, Lanier SM, Duzic E (1999) Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. Nat Biotechnol 17:878-883.
12. Cismowski MJ, Ma C, Ribas C, Xie X, Spruyt M, Lizano JS, Lanier SM, Duzic E (2000) Activation of heterotrimeric G-protein signaling by a Ras-related protein. J Biol Chem 275:23421-23424.
13. Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR (1993) Substitution of three amino acids switches receptor specificity of Gqa to that of Giα. Nature 363:274-276.
14. Denker SP, Mc Caffery JM, Palade GE, Insel PA, Farquhar MG (1996) Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric proteins in Golgi membranes of the exocrine pancreas. J Cell Biol 133:1027-1040.
15. Feinstein P, Bozza T, Rodriguez I, Vassalli A, Mombaerts P (2004) Axon guidance of mouse olfactory sensory neurons by odorant receptors and the β2 adrenergic receptor. Cell 117:833-846.
16. Finley RL, Brent R (1994) Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Proc Natl Acad Sci USA 91:12980-12984.
17. Firestein S (2001) How the olfactory system makes scents of scents. Nature 413:211-218.
18. Gerdeman GL, Partridge JG, Lupica CR, Lovinger DM (2003) It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci 26:184-192.
19. Golemis E, Serebriiskii I, Finley R, Kolonin M, Gyuris J, Brent R (1999) Interaction trap/two-hybrid system to identify interacting proteins. In: Current protocols in molecular biology, pp 20.1.1-20.1.40. New York: Wiley.
20. Graybiel AM (2000) The basal ganglia. Curr Biol 10:R509-R511.
21. Hall A (1998) G proteins and small GTPases: distant relatives keep in touch. Science 280:2074-2075.
22. 1 receptor with adenylyl cyclase. J Neurosci 13:2237-2248.
23. αolf levels are regulated by receptor usage and control dopamine and adenosine action in the striatum. J Neurosci 21:4390-4399.
24. Jones DT, Reed RR (1989) Golf: an olfactory neuron-specific G-protein involved in odorant signal transduction. Science 244:790-795.
25. Jones DT, Masters SB, Bourne HR, Reed RR (1990) Biochemical characterization of three stimulatory GTP-binding proteins. J Biol Chem 265:2671-2676.
26. Klattenhoff C, Montecino M, Soto X, Guzmán L, Romo X, Garcia MLA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J (2003) Human brain synembryn interacts with Gsα and Gqα and is translocated to the plasma membrane in response to isoproterenol and carbachol. J Cell Physiol 195:151-157.
27. olf in rat striatum. Mol Pharmacol 58:771-777.
28. Kurahashi T, Menini A (1997) Mechanism of odorant adaptation in the olfactory receptor cell. Nature 385:725-729.
29. sα short: consequences for receptor-coupling and adenylyl cyclase activation. J Neurochem 78:325-338.
30. Luo Y, Denker BM (1999) Interaction of heterotrimeric G protein Gαo with Purkinje Cell Protein-2. J Biol Chem 274:10685-10688.
31. Miller KG, Rand JB (2000) A role for R1C-8 (Synembrin) and GOA-1 (Goα) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Genetics 156:1649-1660.
32. Miller KG, Alfonso A, Nguyen M, Crowell JA, Johnson CD, Rand JB (1996) A genetic selection for Caenorhabditis elegans synaptic transmission mutants. Proc Natl Acad Sci USA 93:12593-12598.
33. Miller KG, Emerson MD, McManus JR, Rand JB (2000) RIC-8 (Synembrin): a novel conserved protein that is required for Gqα signaling in the C. elegans nervous system. Neuron 27:289-299.
34. Mombaerts P (2004) Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci 5:263-278.
35. 2+-calmodulin- dependent odor adaptation. Science 294:2172-2175.
36. Peppel K, Boekhoff I, McDonald P, Breer H, Caron MG, Lefkowitz RJ (1997) G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J Biol Chem 272:25425-25428.
37. Pimplikar SW, Simons K (1993) Regulation of apical transport by a Gs class of heterotrimeric G protein. Nature 362:456-458.
38. Ronnett GV, Moon C (2002) G proteins and olfactory signal transduction. Annu RevPhysiol 64:189-222.
39. Sato M, Kataoka R, Dingus J, Wilcox M, Hildebrandt JD, Lanier SM (1995) Factors determining specificity of signal transduction by G-protein-coupled receptors. J Biol Chem 270:15269-15276.
40. Sato M, Ribas C, Hildebrandt JD, Lanier SM (1996) Characterization of a G-protein activator in the neuroblastoma-glioma cell hybrid NG108-15*. J Biol Chem 271:30052-30060.
41. Schaeren-Wiemers N, Gerfin-Moser A (1993) A single protocol to detect transcripts of various types and expression levels in neural tissue and culture cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100:431-440.
42. Sinnarajah S, Dessauer CW, Srikumar D, Chen J, Yuen J, Yilma S, Dennis JC, Morrison EE, Vodyanoy V, Kehrl JH (2001) RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature 409:1051-1055.
43. Sprang S (2001) GEFs: master regulators of G-protein activation. Trends Biochem Sci 26:266-267.
44. o is a major growth cone protein subject to regulation by GAP-43. Nature 344:836-841.
45. Tall GG, Krumins AM, Gilman AG (2003) Mammalian Ric-8A (synembryn) is a heterotrimeric Gα protein guanine nucleotide exchange factor. J Biol Chem 278:8356-8362.
46. Wei J, Zhao AZ, Chan GCK, Baker LP, Impey S, Beavo JA, Storm DR (1998) Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: a mechanism for attenuation of olfactory signals. Neuron 21:495-504.
47. Wong ST, Trinh K, Hacker B, Chan GCK, Lowe G, Gaggar A, Xia Z, Gold GH, Storm DR (2000) Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron 27:487-497.
48. Zheng C, Feinstein P, Bozza T, Rodriguez I, Mombaerts P (2000) Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit. Neuron 26:81-91.
49. 1 receptor signaling. J Neurosci 20:RC91(1-5).
50. Zufall F, Leinders-Zufall T (2000) The cellular and molecular basis of odor adaptation. Chem Senses 25:473-481.