Differential state-dependent modification of rat Na v1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin

Toxicology and Applied Pharmacology

Volumn 257, Issue 3, 2011, Pages 377-387

  He, Bingjun ^a   Soderlund, David M ^b  

^a NANKAI UNIVERSITY   (China)

^b New York State Agricultural Experiment Station   (United States)

Author keywords

Deltamethrin; HEK293 cells; Na v1.6 isoform; Pyrethroid; Tefluthrin; Voltage gated sodium channel

Indexed keywords

DELTAMETHRIN; INSECTICIDE; PYRETHROID; SODIUM CHANNEL NAV1.6; TEFLUTHRIN; UNCLASSIFIED DRUG; 2,3,5,6 TETRAFLUORO 4 METHYLBENZYL (Z) (1RS) CIS 3 (2 CHLORO 3,3,3 TRIFLUOROPROP 1 ENYL) 2,2 DIMETHYLCYCLOPROPANECARBOXYLATE; 2,3,5,6-TETRAFLUORO-4-METHYLBENZYL (Z)-(1RS)-CIS-3-(2-CHLORO-3,3,3-TRIFLUOROPROP-1-ENYL)-2,2-DIMETHYLCYCLOPROPANECARBOXYLATE; CYCLOPROPANE DERIVATIVE; FLUORINATED HYDROCARBON; NITRILE; SCN8A PROTEIN, RAT; SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DEPOLARIZATION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; NONHUMAN; OOCYTE; RAT; REPOLARIZATION; SODIUM CURRENT; XENOPUS; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PATCH CLAMP; SPECIES DIFFERENCE;

RATTUS;

ANIMALS; CYCLOPROPANES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; HYDROCARBONS, FLUORINATED; INSECTICIDES; NITRILES; PATCH-CLAMP TECHNIQUES; PYRETHRINS; RATS; SODIUM CHANNELS; SPECIES SPECIFICITY;

EID: 84855717754     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.09.021     Document Type: Article

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