Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides

Biochemical Journal

Volumn 419, Issue 2, 2009, Pages 377-385

  Du, Yuzhe ^a   Lee, Jung Eun ^a   Nomura, Yoshiko ^a   Zhang, Tianxinag ^a   Zhorov, Boris S ^b   Dong, Ke ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Batrachotoxin; Cockroach sodium channel; Molecular modelling; Pyrethroid insecticide; Sixth transmembrane segment of domain III (IIIS6); Xenopus oocyte expression system

Indexed keywords

BATRACHOTOXIN; COCKROACH SODIUM CHANNEL; MOLECULAR MODELLING; PYRETHROID INSECTICIDE; SIXTH TRANSMEMBRANE SEGMENT OF DOMAIN III (IIIS6); XENOPUS OOCYTE EXPRESSION SYSTEM;

AMINO ACIDS; CELL MEMBRANES; ESTERS; INSECTICIDES; MODEL STRUCTURES; MOLECULAR MODELING;

SODIUM;

ALANINE; ASPARAGINE; BATRACHOTOXIN; BG SODIUM V CHANNEL; BIOALLETHRIN; BIORESMETHRIN; CIPERMETHRIN; DELTAMETHRIN; FENFLUTHRIN; FLUVALINATE; GLYCINE; INSECTICIDE; ISOLEUCINE; LEUCINE; LYSINE; MEMBRANE PROTEIN; PERMETHRIN; PHENOXYBENZAMINE; PHENYLALANINE; PYRETHROID; SERINE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; INSECT PROTEIN; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; COCKROACH; COMPUTER MODEL; LIPID BILAYER; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; RESIDUE ANALYSIS; SIXTH TRANSMEMBRANE SEGMENT OF DOMAIN III; WILD TYPE; XENOPUS; ANIMAL; CHEMISTRY; ELECTROPHYSIOLOGY; GENETICS; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BLATTARIA;

ANIMALS; COCKROACHES; ELECTROPHYSIOLOGY; INSECT PROTEINS; INSECTICIDES; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRETHRINS; SODIUM CHANNELS;

EID: 64249125023     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20082082     Document Type: Article

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