Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin

NeuroToxicology

Volumn 30, Issue 1, 2009, Pages 81-89

  Tan, Jianguo ^a   Soderlund, David M ^a  

^a New York State Agricultural Experiment Station   (United States)

Author keywords

Human; Nav1.3; Oocyte; Pyrethroid; Rat; Sodium channel; Tefluthrin

Indexed keywords

PROTEIN SUBUNIT; PYRETHROID; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL 1 3 BETA1; VOLTAGE GATED SODIUM CHANNEL 1 3 BETA2; 2,3,5,6 TETRAFLUORO 4 METHYLBENZYL (Z) (1RS) CIS 3 (2 CHLORO 3,3,3 TRIFLUOROPROP 1 ENYL) 2,2 DIMETHYLCYCLOPROPANECARBOXYLATE; 2,3,5,6-TETRAFLUORO-4-METHYLBENZYL (Z)-(1RS)-CIS-3-(2-CHLORO-3,3,3-TRIFLUOROPROP-1-ENYL)-2,2-DIMETHYLCYCLOPROPANECARBOXYLATE; CYCLOPROPANE DERIVATIVE; FLUORINATED HYDROCARBON; INSECTICIDE; NAV1.3 SODIUM CHANNEL, HUMAN; NERVE PROTEIN; SCN3A PROTEIN, RAT; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; FEMALE; HUMAN VERSUS ANIMAL COMPARISON; MEMBRANE STEADY POTENTIAL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; STEADY STATE; XENOPUS LAEVIS; ANIMAL; CELL MEMBRANE POTENTIAL; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; PHYSIOLOGY; PRENATAL DEVELOPMENT; RAT; XENOPUS;

MAMMALIA; RATTUS; XENOPUS LAEVIS;

ANIMALS; CYCLOPROPANES; FEMALE; HUMANS; HYDROCARBONS, FLUORINATED; INSECTICIDES; MEMBRANE POTENTIALS; NERVE TISSUE PROTEINS; OOCYTES; PYRETHRINS; RATS; SODIUM CHANNELS; XENOPUS;

EID: 58549118243     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.10.008     Document Type: Article

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