Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins

British Journal of Pharmacology

Volumn 165, Issue 3, 2012, Pages 741-753

  Yadav, Vivek R ^a   Prasad, Sahdeo ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

apoptosis; Cardamonin; death receptors; ROS; TRAIL

Indexed keywords

2',4' DIHYDROXY 6' METHOXYCHALCONE; CASPASE 3; CASPASE 8; CASPASE 9; CHALCONE DERIVATIVE; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL MEMBRANE; CELL SURVIVAL; CELL TYPE; CHEMOSENSITIZATION; CHRONIC LEUKEMIA; COLON CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; MITOCHONDRION; MULTIPLE MYELOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CHALCONES; COLONIC NEOPLASMS; DOWN-REGULATION; HUMANS; REACTIVE OXYGEN SPECIES; RECEPTORS, DEATH DOMAIN; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 84855698586     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01603.x     Document Type: Article

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