Myocardin-related transcription factor A regulates expression of Bok and Noxa and is involved in apoptotic signaling

Cell Cycle

Volumn 11, Issue 1, 2012, Pages 141-150

  Shaposhnikov, Dmitry ^a   Descot, Arnaud ^a   Schilling, Johannes ^a,b   Posern, Guido ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Actin; Apoptosis; Bok; Mrtf; Noxa; TNF; Transcription

Indexed keywords

ACTIN; BOK PROTEIN; LATRUNCULIN B; MYOCARDIN; MYOCARDIN RELATED TRANSCRIPTION FACTOR A; PROTEIN BCL 2; PROTEIN NOXA; PROTEIN P53; STAUROSPORINE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STIMULATION; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

EID: 84855684236     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.1.18499     Document Type: Article

References (39)

1. Olson EN, Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol 2010; 11:353-65; PMID:20414257; http://dx.doi.org/10.1038/nrm2890.
2. Posern G, Treisman R. Actin' together: serum response factor, its cofactors and the link to signal transduction. Trends Cell Biol 2006; 16:588-96; PMID:17035020; http://dx.doi.org/10.1016/j.tcb.2006.09.008.
3. Miralles F, Posern G, Zaromytidou AI, Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003; 113:329-42; PMID:12732141; http://dx.doi.org/10.1016/S0092-8674(03)00278-2.
4. Mouilleron S, Langer CA, Guettler S, McDonald NQ, Treisman R. Structure of a Pentavalent G-Actin*MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator. Sci Signal 2011; 4:40; PMID:21673315; http://dx.doi.org/10.1126/scisignal.2001750.
5. Pawłowski R, Rajakyla EK, Vartiainen MK, Treisman R. An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A. EMBO J 2010; 29:3448-58; PMID:20818336; http://dx.doi.org/10.1038/emboj.2010.216.
6. Posern G, Miralles F, Guettler S, Treisman R. Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL. EMBO J 2004; 23:3973-83; PMID:15385960; http://dx.doi.org/10.1038/sj.emboj. 7600404.
7. Vartiainen MK, Guettler S, Larijani B, Treisman R. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science 2007; 316:1749-52; PMID:17588931; http://dx.doi.org/10.1126/science. 1141084.
8. Gineitis D, Treisman R. Differential usage of signal transduction pathways defines two types of serum response factor target gene. J Biol Chem 2001; 276:24531-9; PMID:11342553; http://dx.doi.org/10.1074/jbc.M102678200.
9. Selvaraj A, Prywes R. Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. BMC Mol Biol 2004; 5:13; PMID:15329155; http://dx.doi.org/10.1186/1471-2199-5-13.
10. Sun Q, Chen G, Streb JW, Long X, Yang Y, Stoeckert CJ, et al. Defining the mammalian CArGome. Genome Res 2006; 16:197-207; PMID:16365378; http://dx.doi.org/10.1101/gr.4108706.
11. Descot A, Hoffmann R, Shaposhnikov D, Reschke M, Ullrich A, Posern G. Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. Mol Cell 2009; 35:291-304; PMID:19683494; http://dx.doi.org/10.1016/ j.molcel.2009.07.015.
12. Leitner L, Shaposhnikov D, Descot A, Hoffmann R, Posern G. Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators. Mol Cancer 2010; 9:60; PMID:20236507; http://dx.doi.org/10.1186/1476-4598-9-60.
13. Mokalled MH, Johnson A, Kim Y, Oh J, Olson EN. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite out-growth, neuronal migration and brain development. Development 2010; 137:2365-74; PMID:20534669; http://dx.doi.org/10.1242/dev.047605.
14. He A, Kong SW, Ma Q, Pu WT. Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart. Proc Natl Acad Sci USA 2011; 108:5632-7; PMID:21415370; http://dx.doi.org/10.1073/ pnas.1016959108.
15. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, et al. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol 2011; 31:861-75; PMID:21135125; http://dx.doi.org/10.1128/MCB.00836-10.
16. Descot A, Rex-Haffner M, Courtois G, Bluteau D, Menssen A, Mercher T, et al. OTT-MAL is a deregulated activator of serum response factor-dependent gene expression. Mol Cell Biol 2008; 28:6171-81; PMID:18710951; http://dx.doi.org/10. 1128/MCB.00303-08.
17. Franklin-Tong VE, Gourlay CW. A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals. Biochem J 2008; 413:389-404; PMID:18613816; http://dx.doi.org/10.1042/ BJ20080320.
18. Schratt G, Philippar U, Hockemeyer D, Schwarz H, Alberti S, Nordheim A. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. EMBO J 2004; 23:1834-44; PMID:15057274; http://dx.doi.org/10.1038/sj.emboj.7600188.
19. Townsend KJ, Zhou P, Qian L, Bieszczad CK, Lowrey CH, Yen A, et al. Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J Biol Chem 1999; 274:1801-13; PMID:9880563; http://dx.doi.org/10.1074/jbc.274.3.1801.
20. Vickers ER, Kasza A, Kurnaz IA, Seifert A, Zeef LAH, O'Donnell A, et al. Ternary Complex Factor-Serum Response Factor Complex-Regulated Gene Activity Is Required for Cellular Proliferation and Inhibition of Apoptotic Cell Death. Mol Cell Biol 2004; 24:10340-51; PMID:15542842; http://dx.doi.org/10.1128/MCB.24.23. 10340-10351.2004.
21. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8; PMID:10807576; http://dx.doi.org/10.1126/ science.288.5468.1053.
22. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003; 302:1036-8; PMID:14500851; http://dx.doi.org/10.1126/science.1090072.
23. Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem 2004; 279:28367-74; PMID:15102863; http://dx.doi.org/10.1074/jbc.M313526200.
24. Rodriguez JM, Glozak MA, Ma Y, Cress WD. Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis. J Biol Chem 2006; 281:22729-35; PMID:16772296; http://dx.doi.org/10.1074/jbc. M604705200.
25. Ploner C, Kofler R, Villunger A. Noxa: at the tip of the balance between life and death. Oncogene 2008; 27:84-92; PMID:19641509; http://dx.doi.org/10. 1038/onc.2009.46.
26. Elgendy M, Sheridan C, Brumatti G, Martin SJ. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell 2011; 42:23-35; PMID:21353614; http://dx.doi.org/10.1016/j.molcel.2011.02.009.
27. Fei P, Bernhard EJ, El-Deiry WS. Tissue-specific induction of p53 targets in vivo. Cancer Res 2002; 62:7316-27; PMID:12499275.
28. Lau LM, Nugent JK, Zhao X, Irwin MS. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene 2008; 27:997-1003; PMID:17700533; http://dx.doi.org/10.1038/sj.onc.1210707.
29. Hershko T, Ginsberg D. Upregulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis. J Biol Chem 2004; 279:8627-34; PMID:14684737; http://dx.doi.org/10.1074/jbc.M312866200.
30. Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH. BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med 2004; 199:113-24; PMID:14699081; http://dx.doi.org/10.1084/jem.20030613.
31. Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, et al. Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Proc Natl Acad Sci USA 2007; 104:19488-93; PMID:18042711; http://dx.doi.org/10.1073/pnas.0708380104.
32. Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, et al. Ferritin Heavy Chain Upregulation by NFêB Inhibits TNF[alpha]-Induced Apoptosis by Suppressing Reactive Oxygen Species. Cell 2004; 119:529-42; PMID:15537542; http://dx.doi.org/10.1016/j.cell.2004.10.017.
33. Zhou A, Scoggin S, Gaynor RB, Williams NS. Identification of NFêB-regulated genes induced by TNF[alpha] utilizing expression profiling and RNA interference. Oncogene 2003; 22:2054-64; PMID:12673210; http://dx.doi.org/10.1038/sj.onc.1206262.
34. Shibue T, Suzuki S, Okamoto H, Yoshida H, Ohba Y, Takaoka A, et al. Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. EMBO J 2006; 25:4952-62; PMID:17024184; http://dx.doi.org/ 10.1038/sj.emboj.7601359.
35. Schirren CG, Scharffetter K, Hein R, Braun-Falco O, Krieg T. Tumor necrosis factor alpha induces invasiveness of human skin fibroblasts in vitro. J Invest Dermatol 1990; 94:706-10; PMID:2324525; http://dx.doi.org/10.1111/1523- 1747.ep12876280.
36. Phipps LE, Hino S, Muschel RJ. Targeting cell spreading: a method of sensitizing metastatic tumor cells to TRAIL-induced apoptosis. Mol Cancer Res 2011; 9:249-58; PMID:21296861; http://dx.doi.org/10.1158/1541-7786.MCR-11-0021.
37. Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, et al. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem 2002; 277:28853-60; PMID:12019265; http://dx.doi.org/10.1074/jbc.M203190200.
38. Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol 2009; 11:257-68; PMID:19198601; http://dx.doi.org/10.1038/ncb1833.
39. Busche S, Kremmer E, Posern G. E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells. J Cell Sci 2010; 123:2803-9; PMID:20663922; http://dx.doi.org/10.1242/jcs.061887.