Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 901-906

  Roughley, Stephen D ^a   Browne, Helen ^a   MacIas, Alba T ^a   Benwell, Karen ^a   Brooks, Teresa ^a   D'Alessandro, Jalanie ^a   Daniels, Zoe ^a   Dugdale, Sarah ^b   Francis, Geraint ^a   Gibbons, Ben ^b   Hart, Terance ^a   Haymes, Timothy ^b   Kennett, Guy ^b   Lightowler, Sean ^b   Matassova, Natalia ^a   Mansell, Howard ^b   Merrett, Angela ^b   Misra, Anil ^b   Padfield, Anthony ^b   Parsons, Rachel ^a   Pratt, Robert ^b   Robertson, Alan ^a   Simmonite, Heather ^a   Tan, Kiri ^b   Walls, Steven B ^a   Wong, Melanie ^a   more..

^a Vernalis PLC   (United Kingdom)

^b Vernalis (RandD) Ltd   (United Kingdom)

Author keywords

Anandamide; Azetidine; Cannabinoid signalling; Fatty acid amide hydrolase (FAAH) inhibitor; Urea

Indexed keywords

AZETIDINE DERIVATIVE; FATTY ACID AMIDASE INHIBITOR; TETRASUBSTITUTED AZETIDINE UREA FATTY ACID AMIDASE INHIBITOR; UNCLASSIFIED DRUG; UREA DERIVATIVE; VER 156084;

ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG STRUCTURE; HUMAN; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANIMALS; AZETIDINES; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

RATTUS; TETRA;

EID: 84855678119     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.032     Document Type: Article

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