Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6545-6553

  Meyers, Marvin J ^a,b   Long, Scott A ^a   Pelc, Matthew J ^a   Wang, Jane L ^a   Bowen, Scott J ^a   Schweitzer, Barbara A ^a   Wilcox, Mark V ^a   McDonald, Joseph ^a   Smith, Sarah E ^a   Foltin, Susan ^a   Rumsey, Jeanne ^a   Yang, Young Sun ^a   Walker, Mark C ^a   Kamtekar, Satwik ^a   Beidler, David ^a   Thorarensen, Atli ^a,b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

Author keywords

Endocannabinoid; FAAH; Fatty acid amide hydrolase; Irreversible inhibitor; Pain

Indexed keywords

1 OXA 8 AZASPIRO[4.5]DECANE; 7 AZASPIRO[3.5]NONANE; ANALGESIC AGENT; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; OXAZOLE DERIVATIVE; PF 04862853; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VIVO STUDY; MOLECULAR WEIGHT; NONHUMAN; PAIN; RAT;

EID: 80054791082     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.048     Document Type: Article

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