Parenteral nutrition: Risks, complications, and management

Journal of Infusion Nursing

Volumn 35, Issue 1, 2012, Pages 52-64

  Worthington, Patricia H ^a   Gilbert, Karen A ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALPHA TOCOPHEROL; BISPHOSPHONIC ACID DERIVATIVE; CAFFEINE; CALCIUM; CARBOHYDRATE; CHLORIDE; CHROMIUM; COPPER; GLUCOSE; LIPID EMULSION; MAGNESIUM; MANGANESE; METRONIDAZOLE; NEOMYCIN; PARATHYROID HORMONE[1-34]; PHOSPHORUS; POTASSIUM; PROTEIN; RETINOL; SELENIUM; SODIUM; URSODEOXYCHOLIC ACID; VITAMIN D; VITAMIN K GROUP; ZINC;

ARTICLE; BLOODSTREAM INFECTION; CATHETER INFECTION; CENTRAL VENOUS CATHETER; CHRONIC LIVER DISEASE; CLOSTRIDIUM DIFFICILE INFECTION; DUAL ENERGY X RAY ABSORPTIOMETRY; ELECTROLYTE DISTURBANCE; ENTERIC FEEDING; ENTEROCUTANEOUS FISTULA; ESSENTIAL FATTY ACID DEFICIENCY; FRACTURE; GASTROINTESTINAL HEMORRHAGE; HEMODYNAMICS; HUMAN; HYPERGLYCEMIA; HYPERNATREMIA; HYPEROSMOLALITY; HYPOCALCEMIA; HYPOKALEMIA; HYPOMAGNESEMIA; HYPONATREMIA; HYPOPHOSPHATEMIA; ILEUS; INTESTINE ULCER; LENGTH OF STAY; LIVER DYSFUNCTION; LIVER TRANSPLANTATION; MACRONUTRIENT; METABOLIC ACIDOSIS; METABOLIC ALKALOSIS; OSTEOMALACIA; OSTEOPOROSIS; PARENTERAL NUTRITION; PHLEBITIS; PRIORITY JOURNAL; SCLERODERMA; SEPSIS; SHORT BOWEL SYNDROME; SMALL INTESTINE OBSTRUCTION; SMOKING CESSATION; UREMIA; VOMITING;

CATHETERIZATION, CENTRAL VENOUS; CATHETERIZATION, PERIPHERAL; COOPERATIVE BEHAVIOR; CRITICAL ILLNESS; CROSS INFECTION; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY PROTEINS; HUMANS; LIVER DISEASES; NUTRITIONAL STATUS; PARENTERAL NUTRITION; PATIENT CARE TEAM; RISK FACTORS; TRACE ELEMENTS; UNITED STATES;

EID: 84855654944     PISSN: 15331458     EISSN: 15390667     Source Type: Journal    
DOI: 10.1097/NAN.0b013e31823b98ef     Document Type: Article

References (79)

1. Braunschweig C, Hui Fang L, Sheean P. Indications for administration of parenteral nutrition in adults. Nutr Clin Pract. 2004;19(3):255-262. (Pubitemid 38747823)
2. American Society for Parenteral and Enteral Nutrition, Board of Directors and Clinical Guidelines Task Force. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. J Parenter Enteral Nutr. 2002;26(1)(suppl):1SA-138SA.
3. Task Force for the Revision of Safe Practices for Parenteral Nutrition. Safe practices for parenteral nutrition. J Parenter Enteral Nutr. 2004;28(suppl):S39-S70.
4. Schneider PJ. Nutrition support teams: an evidence-based practice. Nutr Clin Pract. 2006;21(1):62-67. (Pubitemid 43190707)
5. Ukleja A, Freeman KL, Gilbert K, et al; Task Force on Standards for Nutrition Support: Adult Hospitalized Patients, and the American Society for Parenteral and Enteral Nutrition Board of Directors. Standards for nutrition support: adult hospitalized patients. Nutr Clin Pract. 2010;25(4):403-414.
6. Canada T, Crill C, Guenter P, eds. A.S.P.E.N. Parenteral Nutrition Handbook. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2009:77.
7. The Veterans Affairs Total Parenteral Nutrition Cooperative Group. Perioperative total parenteral nutrition in surgical patients. N Engl J Med. 1991;325(8):525-532.
8. Martindale RG, Sawai R, Warren M. Sepsis and infection. In: Gottschlich MM, ed. The A.S.P.E.N. Nutrition Support Core Curriculum: A Case-Based Approach-The Adult Patient. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2007:445-454.
9. Koretz RL, Lipman TO, Klein S. AGA technical review: parenteral nutrition. Gastroenterology. 2001;121(4):970-1001. (Pubitemid 32959408)
10. McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. J Parenter Enteral Nutr. 2009;33(3):277-315.
11. Infusion Nursing Society. Infusion nursing standards of practice. J Infus Nurs. 2011;34(1S):S1-S109.
12. Gura KM. Is there still a role for peripheral parenteral nutrition? Nutr Clin Pract. 2009;24(6):709-717.
13. American Society for Parenteral and Enteral Nutrition, Board of Directors and Task Force on Parenteral Nutrition Standardization. A.S.P.E.N. statement on parenteral nutrition standardization. J Parenter Enteral Nutr. 2007;31(5):441-448.
14. Malone AM. Permissive underfeeding: its appropriateness in patients with obesity, patients on parenteral nutrition, and nonobese patients receiving enteral nutrition. Curr Gastroenterol Rep. 2007;9(4):317-322. (Pubitemid 47489991)
15. Hamwi GJ. Therapy Changing Dietary Concepts in Diabetes Mellitus: Diagnosis and Treatment. New York, NY: ADA Association; 1964:73-78.
16. Kumpf VJ, Gervasio J. Complications of parenteral nutrition. In: Gottschlich MM, ed. The A.S.P.E.N. Nutrition Support Core Curriculum: A Case-Based Approach-The Adult Patient. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2007:323-339.
17. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359-1367.
18. The NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2001;360(13):1283-1297.
19. Kavanagh BP, McCowen C. Glycemic control in the ICU. N Engl J Med. 2010;363(26):2540-2560.
20. American Society for Parenteral and Enteral Nutrition. Information to use in the event of an intravenous fat emulsion shortage. http://www.nutritioncare. org/Press-Room/Press-Releases/A-S-P-E-N-Issues-Recommendations-to-Preemptively- Conserve-Fat-Emulsion/. Accessed November 29, 2011.
21. Mirtallo JM, Dasta JF, Kleinschmidt KC, Varon J. State of the art review: intravenous fat emulsions: current applications, safety profile, and clinical applications. Ann Pharmacother. 2010;44(4):688-700.
22. Cavicchi M, Brau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med. 2000;132(7):525-532. (Pubitemid 30171891)
23. Intralipid (IV fat emulsion) [package insert]. Uppsala, Sweden: Fresenius Kabi AB; April 2007.
24. Hise ME, Brown JC. Lipids. In: Gottschlich MM, ed. The A.S.P.E.N. Nutrition Support Core Curriculum: A Case-Based Approach-The Adult Patient. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2007:48-70.
25. Barber JR, Rollins CJ, Sacks GS. Parenteral nutrition formulations. In: Gottschlich MM, ed. The A.S.P.E.N. Nutrition Support Core Curriculum: A Case-Based Approach-The Adult Patient. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2007:277-299.
26. Khan LUR, Ahmed J, Khan S, MacFie J. Refeeding syndrome: a literature review [published online ahead of print August 25, 2010]. Gastroenterol Res Pract. 2011;2011. doi:10.1155/2011/410971.
27. Kraft M, Btaiche I, Sacks G. Review of the refeeding syndrome. Nutr Clin Pract. 2005;20(6):625-633. (Pubitemid 41790075)
28. Centers for Disease Control and Prevention (CDC). Lactic acidosis traced to thiamine deficiency related to nationwide shortage of multivitamins for total parenteral nutrition-United States, 1997. MMWR Morb Mortal Wkly Rep. 1997;46(23):523-528.
29. Buchman AL, Howard LJ, Guenter P, Nishikawa RA, Compher C, Tappenden KA. Micronutrients in parenteral nutrition: too little or too much? The past, present, and recommendations for the future. Gastroenterology. 2009;137(5)(suppl):S1-S6.
30. Fitzgerald K, Mikalunas V, Rubin H, McCarthy R, Vanagunas A, Craig RM. Hypermanganesemia in patients receiving total parenteral nutrition. J Parenter Enteral Nutr. 1999;23(6):333-336.
31. Howard L, Ashley C, Lyon D, Shenkin A. Autopsy tissue trace elements on 8 long-term parenteral nutrition patients who receive the current U.S. Food and Drug Administration Formulation. J Parenter Enteral Nutr. 2007;31(5):388-396. (Pubitemid 47357106)
32. Dimick JB, Swoboda S, Talamini MA, Pelz RK, Hendrix CW, Lipsett PA. Risk of colonization of central venous catheters: parenteral nutrition vs other catheters. Am J Crit Care. 2003;12(4):328-335.
33. Centers for Disease Control and Prevention (CDC). Vital signs: central line-associated bloodstream infections-United States, 2001, 2008, and 2009. MMWR Morb Mortal Wkly Rep. 2011;60(8):243-248.
34. Institute for Healthcare Improvement. Implement the central line bundle. http://www.ihi.org/knowledge/Pages/Changes/ImplementtheCentralLineBundle.aspx. Accessed November 29, 2011.
35. Marschall J, Mermel LA, Classen D, et al. Strategies to prevent central line-associated bloodstream infection in acute care hospitals. Infect Control Hospital Epidemiol. 2008;29(1)(suppl):S22-S30.
36. Yilmaz G, Koksal I, Aydin K, Caylan R, Sucu N, Aksoy F. Risk factors of catheter-related bloodstream infections in parenteral nutrition catheterization. J Parenter Enteral Nutr. 2007;31(4):284-287. (Pubitemid 47025690)
37. Beghetto MG, Victorino J, Teixeira L, de Azevedo MJ. Parenteral nutrition as a risk factor for central venous catheter-related infection. J Parenter Enteral Nutr. 2005;29(5):367-373. (Pubitemid 44296705)
38. Matsushima K, Cook A, Tyner T, et al. Parenteral nutrition: a clear and present danger unabated by tight glucose control. Am J Surg. 2010;200(3):386-390.
39. Stratman RC, Martin CA, Rapp RP, Berger R, Magnuson B. Candidemia in recipients of parenteral nutrition. Nutr Clin Pract. 2010;25(3):282-289.
40. Zillerberg MD, Shorr AF. Fungal infections in the ICU. Infect Dis Clin N Am. 2009;23:625-642.
41. Kuwahara T, Kaneda S, Shimono K, Inoue Y. Growth of microorganisms in total parenteral nutrition solutions without lipid. Int J Med Sci. 2010;7(1):43-47.
42. O'Grady NP, Alexander M, Burns LA, et al. Guidelines for the prevention of intravascular catheter-related infections, 2011. Centers for Disease Control and Prevention. http://www.cdc.gov/hicpac/pdf/guidelines/bsi-guidelines-2011. pdf.
43. Wanten GJA, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr. 2007;85(5):1171-1184. (Pubitemid 46740457)
44. A.S.P.E.N. response to patient deaths in Alabama from contaminated parenteral nutrition-IV nutrition [news release]. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; March 30, 2011. http://www.nutritioncare.org/News/Industry-and-Product-News/A-S-P-E-N-Response- to-Parenteral-utrition-Contamination-Deaths. Accessed May 3, 2011.
45. CDC and ADPH investigate outbreak at Alabama hospitals; products recalled [news release]. Silver Spring, MD: US Food and Drug Administration; March 29, 2011. http://www.fda.gov/Safety/Recalls/ucm249068.htm. Accessed May 3, 2011.
46. Ryder M. Evidence-based practice in the management of vascular access devices for home parenteral nutrition. J Parenter Enteral Nutr. 2006;30(1)(suppl):S82-S93. (Pubitemid 43099747)
47. Machado JDC, Suen VMM, de Castro Figueiredo JF, Marchini JS. Biofilms, infection, and parenteral nutrition. J Parenter Enteral Nutr. 2009;33(4):397-403.
48. Gilbert KA, Worthington PH, Schechter LN, Cornaglia C. Parenteral nutrition-associated CLABSI in the era of bundles [abstract]. Nutr Clin Pract. 2011;26(1):94.
49. DeChicco R, Seidner DL, Brun C, Stafford J, Lopez R. Tip position of long-term central venous access devices used for parenteral nutrition. J Parenter Enteral Nutr. 2007;31(5):382-387. (Pubitemid 47357105)
50. Vesely TM. Central venous catheter tip location: a continuing controversy. J Vasc Interv Radiol. 2003;14(5):527-534. (Pubitemid 36618018)
51. Sansivero GE. Features and selection of vascular access devices. Semin Oncol Nurs. 2010;26(2):88-101.
52. Agency for Healthcare Research and Quality. Eliminating CLABSI: A National Patient Safety Imperative. http://www.ahrq.gov/qual/onthecusprpt. Accessed May 3, 2011.
53. Royer T. Implementing a better bundle to achieve and sustain a zero central line-associated bloodstream infection rate. J Infus Nurs. 2010;33(6):398-406.
54. Macklin D. The impact of IV connectors on clinical practice and patient outcomes. J Assoc Vasc Access. 2010;15(30):126-139.
55. Btaiche IF, Kovacevich DS, Khaldi N, Papke LF. The effects of needleless connectors on catheter-related bloodstream infections. Am J Infect Control. 2011;39(4):277-283.
56. Mahieu LM, De Muynck AO, Ieven MM, De Dooy JJ, Goossens HJ, Van Reempts PJ. Risk factors for central vascular catheter associated bloodstream infections among patients in a neonatal intensive care unit. J Hosp Infect. 2001;48:108-116. (Pubitemid 32700710)
57. Maragakis LL, Bradley KL, Song X, et al. Increased catheterrelated bloodstream infection rates after the introduction of a new mechanical valve intravenous access port. Infect Control Hosp Epidemiol. 2006;27(1):67-70. (Pubitemid 46939753)
58. Gilbert KA, Worthington PH, Cornaglia C, Henss S, Sullivan J. Central venous catheter infections and blood drawing: an association? [abstract]. Nutr Clin Pract. 2008;23(2):97.
59. Segreti J, Garcia-Houchins S, Gorski L, et al. Consensus conference on prevention of central-line associated bloodstream infections: 2009. J Infus Nurs. 2011;34(2):126-133.
60. Lee V. Liver dysfunction associated with parenteral nutrition: what are the options? Practical Gastroenerol. 2006;45:49-68. (Pubitemid 46032829)
61. Ukleja A, Romano MM. Complications of parenteral nutrition. Gastroenterol Clin N Am. 2007;36(1):23-46. (Pubitemid 46654718)
62. Jeejeebhoy KN. Management of PN-induced cholestasis. Pract Gastroenterol. 2006;45:49-68.
63. Kumpf VJ. Parenteral nutrition associated liver disease in adult and pediatric patients. Nutr Clin Pract. 2006;21(3):279-290.
64. Krawinkel MB. Parenteral nutrition-associated cholestasis: what do we know, what can we do? Eur J Pediatr Surg. 2004;14:230-234. (Pubitemid 39222695)
65. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJA. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intensive Care Med. 2010;36(5):735-749.
66. Clayton PT, Bowron A, Mills KA, et al. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology. 1993;105:1806-1813. (Pubitemid 24002799)
67. Cober MP, Teitelbaum DH. Prevention of parenteral nutritionassociated liver disease: lipid minimization. Curr Opin Organ Transplant. 2010;15(3):330-333.
68. de Meijer VE, Gura KM, Meisel JA, Le HD, Puder M. Parenteral fish oil monotherapy in the management of patients with parenteral nutrition-associated liver disease. Arch Surg. 2010;145(6):547-551.
69. Driscoll DF. Lipid injectable emulsions: 2006. Nutr Clin Pract. 2006;21(4):381-386.
70. Howard L, Ashley C. Management of complications in patients receiving home parenteral nutrition. Gastroenterology. 2003;124(6):1651-1661. (Pubitemid 36617683)
71. Hwang TL, Lue MC, Chen LL. Early use of cyclic TPN prevents further deterioration of liver functions for the TPN patients with impaired liver function. Hepatogastroenterology. 2000;47(35):1347-1350.
72. Kumpf VJ, Gervasio J. Complications of parenteral nutrition. In: Gottschlich MM, ed. The A.S.P.E.N. Nutrition Support Core Curriculum: A Case-Based Approach-The Adult Patient. Silver Spring, MD: American Society for Parenteral and Enteral Nutrition; 2007:323-339.
73. Vanderhoof JA, Young RJ, Murray N, Kaufmann SS. Treatment strategies for small bowel bacterial overgrowth in short bowel syndrome. J Pediatr Gastroenterol Nutr. 1998;27:155-160. (Pubitemid 28354946)
74. Buchman AL, Iyer K, Fryer J. Parenteral nutrition-related liver disease and the role for isolated intestine and intestine/liver transplantation. Hepatology. 2006;43(1):9-19. (Pubitemid 43733585)
75. Dimartini A, Rovera GM, Graham TO, et al. Quality of life after small intestinal transplantation and among home parenteral nutrition patients. J Parenter Enteral Nutr. 1998;22(6):357-362. (Pubitemid 28520511)
76. Weseman RA, Gilroy R. Nutrition management of small bowel transplant patients. Nutr Clin Pract. 2005;20(5):509-516. (Pubitemid 350042714)
77. Ferrone M, Geraci M. A review of the relationship between parenteral nutrition and bone disease. Nutr Clin Pract. 2007;22(3):329-339.
78. Seidner D. Parenteral-nutrition associated metabolic bone disease. J Parenter Enteral Nutr. 2002;26(5)(suppl):S37-S42. (Pubitemid 34920293)
79. Hamilton C, Seidner DL. Metabolic bone disease and parenteral nutrition. Curr Gastroenterol Rep. 2004;6(4):335-340.