Review of the refeeding syndrome

Nutrition in Clinical Practice

Volumn 20, Issue 6, 2005, Pages 625-633

  Kraft, Michael D ^a,b   Btaiche, Imad F ^a,b   Sacks, Gordon S ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; ACETYL COENZYME A; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; AMINO ACID; CREATININE; DIURETIC AGENT; GLUCOSE; MAGNESIUM; MAGNESIUM SULFATE; OXYGEN; PHOSPHATE; PHOSPHORUS; POTASSIUM; POTASSIUM DERIVATIVE; POTASSIUM DIHYDROGEN PHOSPHATE; PROTEIN; PYRUVATE DEHYDROGENASE; SODIUM; SODIUM DIHYDROGEN PHOSPHATE; THIAMINE;

ABDOMINAL CRAMP; CLINICAL FEATURE; CLINICAL PROTOCOL; DIARRHEA; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG DOSE REGIMEN; ELECTROLYTE DISTURBANCE; FLUID BALANCE; GASTROINTESTINAL SYMPTOM; HEART DISEASE; HEMATOLOGIC DISEASE; HIGH RISK PATIENT; HUMAN; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; LUNG DISEASE; MALNUTRITION; MEDICAL LITERATURE; METABOLIC DISORDER; NEUROLOGIC DISEASE; NEUROMUSCULAR DISEASE; NUTRITIONAL SUPPORT; PATHOPHYSIOLOGY; PHOSPHATE BLOOD LEVEL; POTASSIUM BLOOD LEVEL; REFEEDING; REFEEDING SYNDROME; REVIEW; RISK ASSESSMENT; STARVATION; THIAMINE DEFICIENCY; THROMBOPHLEBITIS; VITAMIN DEFICIENCY;

EID: 29044433866     PISSN: 08845336     EISSN: None     Source Type: Journal    
DOI: 10.1177/0115426505020006625     Document Type: Review

References (84)

1. Keys A, Brozek J, Henschel A, Mickelson O, Taylor HD, eds. The Biology of Human Starvation, Vols. 1, 2. Minneapolis, MN: University of Minnesota Press; 1950.
2. Weinsier RL, Krumdieck CL. Death resulting from overzealous total parenteral nutrition: the refeeding syndrome revisited. Am J Clin Nutr. 1980;34:393-399.
3. Cahill GF. Starvation in man. N Engl J Med. 1970;282:668-675.
4. DeFronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ. The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest. 1975;55:845-855.
5. Guirao X, Franch G, Gil MJ, Garcia-Domingo MI, Girvent M, Sitges-Serra A. Extracellular volume, nutritional status, and refeeding changes. Nutrition. 1994;10:558-561.
6. Van Way CW, Longoria M, Sacks GS. Do surgeons need to worry about vitamin deficiencies? Nutr Clin Pract. 2001;16(suppl):S5-S7.
7. Travis SF, Sugerman HJ, Ruberg RL, et al. Alterations of red-cell glycolytic intermediates and oxygen transport as a consequence of hypophosphatemia in patients receiving intravenous hyperalimentation. N Engl J Med. 1971;285:763-768.
8. Silvis SE, Paragas PD. Paresthesias, weakness, seizures, and hypophosphatemia in patients receiving hyperalimentation. Gastroenterology. 1972;62:513-520.
9. Sand DW, Pastore RA. Paresthesias and hypophosphatemia occurring with parenteral alimentation. Am J Dig Dis. 1973;18:709-713.
10. Furlan AJ, Hanson M, Cooperman A, Farmer RG. Acute are flexic paralysis: association with hyperalimentation and hypophosphatemia. Arch Neurol. 1975;32:706-707.
11. Sheldon GF, Grzyb S. Phosphate depletion and repletion: relation to parenteral nutrition and oxygen transport. Ann Surg. 1975;182:683-689.
12. Baughman FA Jr, Papp JP. Wernicke's encephalopathy with intravenous hyperalimentation: remarks on similarities between Wernicke's encephalopathy and the phosphate depletion syndrome. Mt Sinai J Med. 1976;43:48-52.
13. Silvis SE, DiBartolomeo AG, Aaker HM. Hypophosphatemia and neurological changes secondary to oral caloric intake. Am J Gastroentenerol. 1980;73:215-222.
14. Youssef HAE. Hypophosphatemic respiratory failure complicating PN: an iatrogenic potentially lethal hazard [letter]. Anesthesiology. 1982;57:246.
15. Hayek ME, Eisenberg PG. Severe hypophosphatemia following the institution of enteral feedings. Arch Surg. 1989;124:1325-1328.
16. Vanneste J, Hage J. Acute severe hypophosphatemia mimicking Wernicke's encephalopathy [letter]. Lancet. 1986;1:44.
17. Mattioli S, Miglioli M, Montagna P, Lerro MF, Pilotti V, Gozzetti G. Wernicke's encephalopathy during PN: observation in one case. JPEN J Parenter Enteral Nutr. 1988;12:626-627.
18. O'Connor LR, Wheeler WS, Bethune JE. Effect of hypophosphatemia on myocardial performance in man. N Engl J Med. 1977;297:901-903.
19. Newman JH, Neff TA, Ziporin P. Acute respiratory failure associated with hypophosphatemia. N Engl J Med. 1977;296:1101-1103.
20. Aubier M, Murciano D, Lecocguic Y, et al. Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med. 1985;313:420-424.
21. Benesch R, Benesch RE. The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem Biophys Res Commun. 1967;26:162-167.
22. Lichtman MA, Miller DR, Cohen J, Waterhouse C. Reduced red cell glycolysis, 2,3-diphosphoglycerate and adenosine triphosphate concentration, and increased hemoglobin-oxygen affinity caused by hypophosphatemia. Ann Intern Med. 1971;74:562-568.
23. Thomas HM, Lefrak SS, Irwin RS, Fritts Jr HW, Caldwell PRB. The oxyhemoglobin dissociation curve in health and disease: role of 2,3-diphosphoglycerate. Am J Med. 1974;57:331-348.
24. Mandal AK. Hypokalemia and hyperkalemia. Med Clin North Am. 1997;81:611-639.
25. Halperin ML, Kamel KS. Potassium. Lancet. 1998;352:135-140.
26. Freedman BI, Burkart JM. Hypokalemia. Crit Care Clin. 1991;7:143-153.
27. th ed. New York, NY: McGraw-Hill; 2002:981-993.
28. Gennari FJ. Hypokalemia. N Engl J Med. 1998;339:451-458.
29. Agarwal A, Wingo CS. Treatment of hypokalemia. N Engl J Med. 1999;340:154-155.
30. Wacker WEC, Parisi AF. Magnesium metabolism. N Engl J Med. 1968;278:658-663, 712-717, 772-776.
31. Graber TW, Yee AS, Baker FJ. Magnesium: physiology, clinical disorders, and therapy. Ann Emerg Med. 1981;10:49-57.
32. Reinhart RA. Magnesium metabolism: a review with special reference to the relationship between intracellular content and serum levels. Arch Intern Med. 1988;148:2415-2420.
33. Wacker WE. The biochemistry of magnesium. Ann N Y Acad Sci. 1969;162:717-726.
34. Reinhart RA, Desbiens NA. Hypomagnesemia in patients entering the ICU. Crit Care Med. 1985;13:506-507.
35. Ryzen E, Wagers PW, Singer FR, Rude RK. Magnesium deficiency in a medical ICU population. Crit Care Med. 1985;13:19-21.
36. Chernow B, Bamberger S, Stoiko M, et al. Hypomagnesemia in patients in postoperative intensive care. Chest. 1989;95:391-397.
37. Frankel H, Haskell R, Lee SY, et al. Hypomagnesemia in trauma patients. World J Surg. 1999;23:966-969.
38. Rubiez GJ, Thill-Baharozian M, Hardie D, Carlson RW. Association of hypomagnesemia and mortality in acutely ill medical patients. Crit Care Med. 1993;21:203-209.
39. Ceremuzynski L, Hao NV. Ventricular arrhythmias late after myocardial infarction are related to hypomagnesemia and magnesium loss: preliminary trial of corrective therapy. Clin Cardiol. 1993;16:493-496.
40. Kingston ME, Al-Siba'I MB, Skooge WC. Clinical manifestations of hypomagnesemia. Crit Care Med. 1986;14:950-954.
41. Salem M, Munoz R, Chernow B. Hypomagnesemia in critical illness: a common and clinically important problem. Crit Care Clin. 1991;7:225-252.
42. Seelig MS. Electrographic patterns of magnesium depletion appearing in alcoholic heart disease. Ann N Y Acad Sci. 1969;162:906-917.
43. + across the nerve membrane. Biochem Biophys Acta. 1960;42:6-23.
44. Weisinger JR, Bellorin-Font E. Magnesium and phosphorous. Lancet. 1998;352:391-396.
45. Anast CS, Winnacker JL, Forte LR, Burns TW. Impaired release of parathyroid hormone in magnesium deficiency. J Clin Endocrinol Metab. 1976;42:707-717.
46. Fatemi G, Ryzen E, Flores J, Endres DB, Rude RK. Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. J Clin Endocrinol Metab. 1991;73:1067-1072.
47. Reuler JB, Girard DE, Cooney TG. Wernicke's encephalopathy. N Engl J Med. 1985;312:1035-1039.
48. Romanski SA, McMahon MM. Metabolic acidosis and thiamine deficiency. Mayo Clin Proc. 1999;74:259-263.
49. Kitamura K, Takahashi T, Tanaka H, et al. Two cases of thiamine deficiency-induced lactic acidosis during PN. Tohoku J Exp Med. 1993;171:129-133.
50. Barrett TG, Forsyth JM, Nathavitharana KA, Booth IW. Potentially lethal thiamine deficiency complicating parenteral nutrition in children. Lancet. 1993;341:901-902.
51. Centers for Disease Control and Prevention. Deaths associated with thiamine-deficient PN. MMWR Morb Mortal Wkly Rep. 1989;38:43-46.
52. Centers for Disease Control and Prevention. Lactic acidosis traced to thiamine deficiency related to nationwide shortage of multi-vitamins for PN. MMWR Morb Mortal Wkly Rep. 1997;46:523-528.
53. Heymsfield SB, Bethel RA, Ansley JD, Gibbs DM, Feiner JM, Nutter DO. Cardiac abnormalities in cachectic patients before and during nutritional repletion. Am Heart J. 1978;95:584-594.
54. Huang YL, Fang CT, Tseng MC, Lee YJ, Lee MB. Life-threatening refeeding syndrome in a severely malnourished anorexia nervosa patient. J Formos Med Assoc. 2001;100:343-346.
55. Gottdiener JS, Gross HA, Henry WL, Borer JS, Ebert MH. Effects of self-induced starvation on cardiac size and function in anorexia nervosa. Circulation. 1978;58:425-433.
56. Apovian CM, McMahon MM, Bistran BR. Guidelines for refeeding the marasmic patient. Crit Care Med. 1990;18:1030-1033.
57. Nutrition Advisory Group, AMA Department of Foods and Nutrition. Multivitamin preparations for parenteral use, 1975. JPEN J Parenter Enteral Nutr. 1979;3:258-262.
58. Brooks MJ, Melnik G. The refeeding syndrome: an approach to understanding its complications and preventing its occurrence. Pharmacotherapy. 1995;15:713-726.
59. Hankin ME, Munz K, Steinbeck AW. Total body water content in normal and grossly obese women. Med J Aust. 1976;2:533-537.
60. Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr. 1980;33:27-39.
61. 2H labeled water. Am J Clin Nutr. 1980;33:2686-2693.
62. Webster JD, Hesp R, Garrow JS. The composition of excess weight in obese women estimated by body density, total body water and total body potassium. Hum Nutr Clin Nutr. 1984;38:299-306.
63. Foster GD, Wadden TA, Mullen JL, et al. Resting energy expenditure, body composition, and excess weight in the obese. Metabolism. 1988;37:467-472.
64. Lentz RD, Brown DM, Kjellstrand CM. Treatment of severe hypophosphatemia. Ann Intern Med. 1978;89:941-944.
65. Vannatta JB, Whang R, Papper S. Efficacy of intravenous phosphorous therapy in the severely hypophosphatemic patient. Arch Intern Med. 1981;141:885-887.
66. Andress DL, Vannatta JB, Whang R. Treatment of refractory hypophosphatemia. South Med J. 1982;75:766-767.
67. Vannatta JB, Andress DL, Whang R, Papper S. High-dose intravenous phosphorus therapy for severe complicated hypophosphatemia. South Med J. 1983;76:1424-1426.
68. Kingston M, Al-Siba'i MB. Treatment of severe hypophosphatemia. Crit Care Med. 1985;13:16-18.
69. Rosen GH, Boullata JI, O'Rangers EA, Enow NB, Shin B. Intravenous phosphate repletion regimen for critically ill patients with moderate hypophosphatemia. Crit Care Med. 1995;23:1204-1210.
70. Clark CL, Sacks GS, Dickerson RN, Kudsk KA, Brown RO. Treatment of hypophosphatemia in patients receiving specialized nutrition support using a graduated dosing scheme: results from a prospective clinical trial. Crit Care Med. 1995;23:1504-1511.
71. Kruse JA, Carlson RW. Rapid correction of hypokalemia using concentrated intravenous potassium chloride infusions. Arch Intern Med. 1990;150:613-617.
72. Hamill RJ, Robinson LM, Wexler HR, Moote C. Efficacy and safety of potassium infusion therapy in hypokalemic critically ill patients. Crit Care Med. 1991;19:694-699.
73. Kruse JA, Clark VL, Carlson RW, Geheb MA. Concentrated potassium chloride infusions in critically ill patients with hypokalemia. J Clin Pharmacol. 1994;34:1077-1082.
74. Ryan MP. Interrelationships of magnesium and potassium homeostasis. Mineral Electrolyte Metab. 1993;19:290-295.
75. Flink EB. Therapy of magnesium deficiency. Ann N Y Acad Sci. 1969;162:901-905.
76. Heaton FW. The kidney and magnesium homeostasis. Ann N Y Acad Sci. 1969;162:775-785.
77. Martin HE. Clinical magnesium deficiency. Ann N Y Acad Sci. 1969;162:891-900.
78. Dickerson RN, Brown RO. Hypomagnesemia in hospitalized patients receiving nutritional support. Heart Lung. 1985;14:561-569.
79. Rasmussen HS, McNair P, Norregard P, Backer V, Lindeneg O, Balslev S. Intravenous magnesium in acute myocardial infarction. Lancet. 1986;1:234-236.
80. Oster JR, Epstein M. Management of magnesium depletion. Am J Nephrol. 1988;8:349-354.
81. Sacks GS, Brown RO, Dickerson RN, et al. Mononuclear blood cell magnesium content and serum magnesium concentration in critically ill hypomagnesemic patients after replacement therapy. Nutrition. 1997;13:303-307.
82. Hebert P, Mehta N, Wang J, Hindmarsh T, Jones G, Cardinal P. Functional magnesium deficiency in critically ill patients identified using a magnesium-loading test. Crit Care Med. 1997;25:749-755.
83. Huycke MM, Naguib MT, Stroemmel MM, et al. A double-blind placebo-controlled crossover trial of intravenous magnesium sulfate for foscarnet-induced ionized hypocalcemia and hypomagnesemia in patients with AIDS and cytomegalovirus infection. Antimicrob Agents Chemother. 2000;44:2143-2148.
84. Barnes BA. Magnesium conservation: a study of surgical patients. Ann N Y Acad Sci. 1969;162:786-801.