Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging

Molecular Imaging and Biology

Volumn 13, Issue 1, 2011, Pages 59-66

  Keyaerts, Marleen ^a,b,c   Heneweer, Carola ^b,d   Gainkam, Lea O Tchouate ^a   Caveliers, Vicky ^a,c   Beattie, Bradley J ^b   Martens, Geert A ^c   Vanhove, Christian ^a,c   Bossuyt, Axel ^a,c   Blasberg, Ronald G ^b   Lahoutte, Tony ^a,c  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Bioluminescence imaging; Molecular imaging; Protein binding; Small animal imaging; Tumor model

Indexed keywords

ALBUMIN; DOXORUBICIN; FIREFLY LUCIFERASE; LUCIFERASE; LUCIFERIN; RENILLA LUCIFERIN 2 MONOOXYGENASE;

ACCURACY; ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME METABOLISM; HYPOALBUMINEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; PHOTON EMISSION TOMOGRAPHY; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; ULTRAFILTRATION;

ANIMALS; BLOOD PROTEINS; CELL LINE; LUCIFERASES; LUMINESCENCE; MALE; MICE; MICE, NUDE; SUBSTRATE SPECIFICITY;

ANIMALIA; RENILLA LUCIFERASE;

EID: 79551612720     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0325-x     Document Type: Article

References (19)

1. Y Zhang JP Bressler J Neal, et al. 2007 ABCG2/BCRP expression modulates d-luciferin based bioluminescence imaging Cancer Res 67 9389 9397 1:CAS:528:DC%2BD2sXhtFSnurrJ 10.1158/0008-5472.CAN-07-0944 17909048
2. M Keyaerts J Verschueren TJ Bos, et al. 2008 Dynamic bioluminescence imaging for quantitative tumour burden assessment using IV or IP administration of d-luciferin: effect on intensity, time kinetics and repeatability of photon emission Eur J Nucl Med Mol Imaging 35 999 1007 1:CAS:528:DC%2BD1cXkvVyjur4%3D 10.1007/s00259-007-0664-2 18180921
3. JW Pippin PT Brinkkoetter FC Cormack-Aboud, et al. 2009 Inducible rodent models of acquired podocyte diseases Am J Physiol Renal Physiol 296 F213 F229 1:CAS:528:DC%2BD1MXitVejtb4%3D 10.1152/ajprenal.90421.2008 18784259
4. S Baba SY Cho Z Ye, et al. 2007 How reproducible is bioluminescent imaging of tumor cell growth? Single time point versus the dynamic measurement approach Mol Imaging 6 315 322 18092516
5. PV Dickson B Hamner CY Ng, et al. 2007 In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma J Pediatr Surg 42 1172 1179 10.1016/j.jpedsurg.2007.02.027 17618876
6. Z Paroo RA Bollinger DA Braasch, et al. 2004 Validating bioluminescence imaging as a high-throughput, quantitative modality for assessing tumor burden Mol Imaging 3 117 124 10.1162/1535350041464865 15296676
7. A Rehemtulla LD Stegman SJ Cardozo, et al. 2000 Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging Neoplasia 2 491 495 1:STN:280:DC%2BD38%2FgslShsw%3D%3D 10.1038/sj.neo.7900121 11228541
8. DE Jenkins Y Oei YS Hornig, et al. 2003 Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis Clin Exp Metastasis 20 733 744 1:CAS:528:DC%2BD3sXpsV2ktbw%3D 10.1023/B:CLIN. 0000006815.49932.98 14713107
9. Y Inoue A Tojo R Sekine, et al. 2006 In vitro validation of bioluminescent monitoring of disease progression and therapeutic response in leukaemia model animals Eur J Nucl Med Mol Imaging 33 557 565 10.1007/s00259-005-0048-4 16501974
10. F Fan KV Wood 2007 Bioluminescent assays for high-throughput screening Assay Drug Dev Technol 5 127 136 1:CAS:528:DC%2BD2sXislCktbk%3D 10.1089/adt.2006.053 17355205
11. CH Contag SD Spilman PR Contag, et al. 1997 Visualizing gene expression in living mammals using a bioluminescent reporter Photochem Photobiol 66 523 531 1:CAS:528:DyaK1cXivFOquw%3D%3D 10.1111/j.1751-1097.1997.tb03184.x 9337626
12. TF Massoud SS Gambhir 2003 Molecular imaging in living subjects: seeing fundamental biological processes in a new light Genes Dev 17 545 580 1:CAS:528:DC%2BD3sXisVejurY%3D 10.1101/gad.1047403 12629038
13. GD Luker KE Luker 2008 Optical imaging: current applications and future directions J Nucl Med 49 1 4 10.2967/jnumed.107.045799 18077528
14. R Weissleder U Mahmood 2001 Molecular imaging Radiology 219 316 333 1:CAS:528:DC%2BD3MXjs1ekur0%3D 11323453
15. S Bhaumik SS Gambhir 2002 Optical imaging of Renilla luciferase reporter gene expression in living mice Proc Natl Acad Sci U S A 99 377 382 1:CAS:528:DC%2BD38Xlt1Cluw%3D%3D 10.1073/pnas.012611099 11752410
16. DS Auld N Thorne DT Nguyen J Inglese 2008 A specific mechanism for nonspecific activation in reporter-gene assays ACS Chem Biol 3 463 470 1:CAS:528:DC%2BD1cXnvFajt74%3D 10.1021/cb8000793 18590332
17. JF Thompson LS Hayes DB Lloyd 1991 Modulation of firefly luciferase stability and impact on studies of gene regulation Gene 103 171 177 1:CAS:528:DyaK3MXlslKlu78%3D 10.1016/0378-1119(91)90270-L 1889744
18. JJ Lemasters CR Hackenbrock 1977 Kinetics of product inhibition during firefly luciferase luminescence Biochemistry 16 445 447 1:CAS:528: DyaE2sXhtVanurk%3D 10.1021/bi00622a016 836795
19. F Berger R Paulmurugan S Bhaumik SS Gambhir 2008 Uptake kinetics and biodistribution of (14)C-d-luciferin-a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging Eur J Nucl Med Mol Imaging 35 2275 2285 10.1007/s00259-008-0870-6 18661130